Bacteremia due to a VIM-1 Producing Klebsiella Pneumoniae Isolate from an Acute Lymphoblastic Leukemia Patient in Antalya

Abstract

A Klebsiella pneumoniae clinical isolate resistant to imipenem was recovered from blood culture of a 4 years old child with the diagnosis of acute precursor B cell lymphoblastic leukemia. PCR assays of Klebsiella pneumoniae isolate were positive with blaCTX-M and blaVIM genes. Sequence analysis of the 160 bp amplicon matched with blaVIM 1. Patient was discharged on the 15th day of ciprofloxacin theraphy with remission. We report here the first VIM-1 positive Klebsiella pneumoniae isolate case from Akdeniz University Hospital. Urgent and rapid precautions must be preferred including antibiotic policy and infection control practices when the first case with different resistance patern is detected. Key words: K. Pneumoniae; Metallo-Β-Lactamases; VIM 1.

Keywords

• K. Pneumoniae; Metallo-Β-Lactamases; VIM 1.

Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi

Öz

Akut Prekürsör B Hücreli Lenfoblastik Lösemi tanısıyla izlenen 4 yaşındaki bir çocuğun kan kültürü örneğinden imipenem dirençli Klebsiella pneumoniae izole edildi. İzolatın PCR analizi sonuçları VIM ve CTX- M enzimleri açısından pozitif olarak saptandı. Yapılan DNA sekans analizi sonucunda 160bp'lik bölge blaVIM-1 ile uyumlu olarak bulundu. Hasta siprofloksasin tedavisinin 15. gününde remisyonla taburcu edildi. Bu olguda Akdeniz Üniversitesi Hastanesi'nde ilk kez saptanan VIM 1 pozitif Klebsiella pneumoniae izolatı sunulmuştur. Farklı direnç paternine sahip bir vaka görüldüğünde, hızlı bir şekilde antibiyotik politikalarını da içeren infeksiyon kontrol önlemleri alınmalıdır. Anahtar kelimeler: K. Pneumoniae; Metallo-Β-Laktamaz; VIM 1.

Anahtar Kelimeler

• K. Pneumoniae; Metallo-Β-Laktamaz; VIM 1.

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