Double-Hit Lymphoma Presenting with Aggressive Progression: A Case Report

Abstract

Double-Hit lymphoma is an aggressive B-cell malignancy with a high proliferative rate that may be fatal within months if not treated promptly. We presented a very aggressive and fatal case of a Double-Hit Lymphoma. 18 years old male patient referred Ear-Nose-Throat outpatient clinic due to swelling under the chin and an excisional biopsy was performed. High grade Burkitt like lymphoma CD20 (+) was reported. Approximately 12 months after diagnosis patient who was accepted as a stage IIIB according to Ann-Arbor staging system died of disease progression despite the various treatment protocols of high dose chemotherapy followed by autologous bone marrow transplantation. Double-Hit lymphoma is aggressive and can be fatal. Therefore, treatment should be initiated without delay after diagnosis. Key words: Double-Hit Lymphoma; Burkitt Like Lymphoma; Aggressive; Bone Marrow Transplantation.

Keywords

• Double-Hit Lymphoma; Burkitt Like Lymphoma; Aggressive; Bone Marrow Transplantation.

Agresif Seyreden Double-Hit Lenfoma: Bir olgu sunumu

Abstract

Double-Hit lenfoma acil tedavi edilmez ise aylar içinde ölümcül olabilen kötü seyirli B hücreli lenfomadır. Biz burada kötü seyirli giden fatal seyreden Double-Hit Lenfomalı erişkin bir olguyu sunduk. 18 yaşındaki erkek hasta Kulak Burun Boğaz polikliniğine çene altındaki şişlik nedeni ile başvurdu ve eksizyonel biopsi yapıldı. Hastanın biyopsisi CD20(+) Burkitt-like lenfoma olarak rapor edildi. Ann-Arbor evreleme sistemine göre evre IIIB kabul edilen hasta tedavi protokolündeki kemoterapotiklere ve yüksek doz kemoterapi eşliğinde otolog kemik iliği nakline cevap vermedi. Hastamız tanı konulmasından yaklaşık 12 ay sonra kaybedildi. Double-Hit lenfoma agresif gidişli olabilir ve fatal seyirli seyredebilir. Bu yüzden tanıdan sonra zaman kaybetmeden tedavi başlanmalıdır. Anahtar kelimeler: Double-Hit Lenfoma; Burkitt Like Lenfoma; Agresif; Kemik İliği Nakli.

Keywords

• Double-Hit Lenfoma; Burkitt Like Lenfoma; Agresif; Kemik İliği Nakli.

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