Urinary Trypsinogen-2 Analysis in Early Diagnosis of Acute Pancreatitis

Abstract

Purpose: The aim of this study is to evaluate the place and importance of the urinary trypsinogen-2 analysis in early diagnosis of acute pancreatitis. Materials and Method: The patients who admitted with abdominal pain to the surgery emergency service of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital were examined prospectively. Results: 76 female and 29 male total 105 patients were included in this study. The mean age was 53.3 (range 19-87). 51 of the patients were acute pancreatitis, 54 of them were the control group with other abdominal pathologies. Urinary trypsinogen-2 was analysed in all patients within 24 hours after admittance. The urinary trypsinogen-2 level was 96.1% positive in patients who was diagnosed as acute pancreatitis and 1.9 % was found positive in the control group (patients who had an extra-pancreatic illness). The sensitivity and specifity of the test was found to be 96% and 92% respectively . Conclusion: Urinary trypsinogen-2 test is a quick, efficient and reliable test in the early diagnosis of acute pancreatitis. Key words: Acute pancreatitis, Urinary tripsinogen-2

Keywords

• Acute pancreatitis, Urinary tripsinogen-2

Akut Pankreatitin Erken Tanısında İdrar Tripsinojen-2 Testinin Yeri

Öz

Amaç: Üriner tripsinojen-2 strip testinin akut pankreatit'in erken tanısındaki yeri ve öneminin araştırılması. Gereç ve Yöntem: Bu çalışma S. B. Ankara Dışkapı Yıldırım Beyazıt E. A. H. Acil Cerrahi Polikliniği'ne karın ağrısı ile başvuran olguların bilgilerinin prospektif olarak incelenmesi sonucunda gerçekleştirildi. Bulgular: Bu çalışmaya 76 kadın, 29 erkek toplam 105 olgu alındı. Yaş ortalaması 53.3 (en az 19-en çok 87) idi. Karın ağrısı ile başvuran 105 olgudan 51'i akut pankreatit, 54'ü de diğer karın hastalıkları olan kontrol grubu idi. Bu olguların hepsinin idrar örnekleri alındı ve başvuruyu takip eden ilk 24 saat içerisinde idrar tripsinojen-2 testi yapıldı. İdrarda tripsinojen-2 düzeyi, akut pankreatit tanısı alan olguların %96.1'inde, kontrol grubundaki olguların (pankreas dışı hastalığı olan olgular) ise %1.9'unda pozitif olarak bulunmuştur. Testin duyarlılığı %96 ve özgüllüğü %92 olarak bulundu. Sonuç: Akut pankreatitin erken tanısında idrar tripsinojen-2 testi hızlı sonuç alınan, etkin ve güvenilir bir yöntemdir. Anahtar kelimeler: Akut pankreatit, İdrar tripsinojen-2

Anahtar Kelimeler

• Akut pankreatit, İdrar tripsinojen-2

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