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Bacteremia due to a VIM-1 Producing Klebsiella Pneumoniae Isolate from an Acute Lymphoblastic Leukemia Patient in Antalya

Year 2014, Volume: 21 Issue: 4, 291 - 293, 01.08.2014

Abstract

A Klebsiella pneumoniae clinical isolate resistant to imipenem was recovered from blood culture of a 4 years old child with the diagnosis of acute precursor B cell lymphoblastic leukemia. PCR assays of Klebsiella pneumoniae isolate were positive with blaCTX-M and blaVIM genes. Sequence analysis of the 160 bp amplicon matched with blaVIM 1. Patient was discharged on the 15th day of ciprofloxacin theraphy with remission. We report here the first VIM-1 positive Klebsiella pneumoniae isolate case from Akdeniz University Hospital. Urgent and rapid precautions must be preferred including antibiotic policy and infection control practices when the first case with different resistance patern is detected. Key words: K. Pneumoniae; Metallo-Β-Lactamases; VIM 1.

References

  • Kimura S, Ishii Y, Yamaguchi K. Evaluation of dipicolinic acid for detection of IMP- or VIM- type metallo-β-lactamase– producing Pseudomonas aeruginosa clinical isolates. Diag Microbiol Infect Dis 2005;53:241-4.
  • Psichogiou M, Tassios PT, Avlamis A, et al. Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey. J Antimicrob Chemother 2008;61:59-63.
  • Ikonomidis A, Tokatlidou D, Kristo I, et al. Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a blaVIM-1 Metallo-ß-Lactamase Gene. J Clin Microbiol 2005;43:5344-7.
  • Kassis-Chikhani N, Saliba F, Carbonne A, et al. Extended measures for controlling an outbreak of VIM-1 producing imipenem-resistant Klebsiella pneumoniae in a liver transplant centre in France, 2003–2004. Euro Surveill 2010;15:pii=19713.
  • Loli A, Tzouvelekis LS, Tzelepi E, et al. Sources of diversity of carbapenem resistance levels in Klebsiella pneumoniae carrying blaVIM-1. J Antimicrob Chemother 2006;58:669–72.
  • Fukigai S,Alba J, Kimura S, et al. Nosocomial outbreak of genetically related IMP-1 β-lactamase-producing Klebsiella pneumoniae in a general hospital in Japan. Int J Antimicrob Agents 2007;29:3306-10.
  • Giakkoupi P, Xanthaki A, Kanelopoulou M, et al. VIM-1 Metallo- β -Lactamase-Producing Klebsiella pneumoniae Strains in Greek Hospitals. J Clin Microbiol 2003; 41:3893–6.
  • EARSS Annual Report 2008. On-going surveillance of S. Pneumoniae, S. aureus, E. coli, E. faecium, E. faecalis, K. pneumoniae, P. Aeruginosa. European Centere For Disease and Control (ECDC) 2008.
  • Pitout JD, Nordmann P, Laupland KB, Poirel L. Emergence of Enterobactericeae producing extended-spectrum beta- lactamases (ESBLs) in the community. J Antimicrob Chemother 2005;56:52-9.
  • Poirel L, Nordmann P. Acquired Carbapenem-Hydrolyzing
  • -Lactamases and their Genetic Support - An Update.
  • Medicinal Chemistry Reviews - Online, 2005;2:183-5.
  • Gacar GG, Midilli K, Kolayli F, et al. Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae. Antimicrob Agents Chemother 2005;49:4400-3.
  • Yıldırım I, Ceyhan M, Gür D, Mugnaioli C, Rossolini GM. First detection of VIM-1 type metallo-beta-lactamase in a multidrug-resistant Klebsiella pneumoniae clinical isolate from Turkey also producing the CTX-M-15 extended- spectrum beta-lactamase. J Chemother 2007;19:467-8.
  • Gudiol C, Tubau F, Calatayud L, et al. Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 2011;66:657-63.
  • Meletis G, Tzampaz E, Protonotariou E, Sofianou D. Emergence of Klebsiella pneumoniae carrying blaVIM and blaKPC genes. Hippokratia 2010;14:139–40.
  • Walsh T R, Toleman M A, Poirel L, Nordmann P. Metallo-β- Lactamases: the Quiet before the Storm? Clin Microbiol Reviews 2005;18:306–25.

Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi

Year 2014, Volume: 21 Issue: 4, 291 - 293, 01.08.2014

Abstract

Akut Prekürsör B Hücreli Lenfoblastik Lösemi tanısıyla izlenen 4 yaşındaki bir çocuğun kan kültürü örneğinden imipenem dirençli Klebsiella pneumoniae izole edildi. İzolatın PCR analizi sonuçları VIM ve CTX- M enzimleri açısından pozitif olarak saptandı. Yapılan DNA sekans analizi sonucunda 160bp'lik bölge blaVIM-1 ile uyumlu olarak bulundu. Hasta siprofloksasin tedavisinin 15. gününde remisyonla taburcu edildi. Bu olguda Akdeniz Üniversitesi Hastanesi'nde ilk kez saptanan VIM 1 pozitif Klebsiella pneumoniae izolatı sunulmuştur. Farklı direnç paternine sahip bir vaka görüldüğünde, hızlı bir şekilde antibiyotik politikalarını da içeren infeksiyon kontrol önlemleri alınmalıdır. Anahtar kelimeler: K. Pneumoniae; Metallo-Β-Laktamaz; VIM 1.

References

  • Kimura S, Ishii Y, Yamaguchi K. Evaluation of dipicolinic acid for detection of IMP- or VIM- type metallo-β-lactamase– producing Pseudomonas aeruginosa clinical isolates. Diag Microbiol Infect Dis 2005;53:241-4.
  • Psichogiou M, Tassios PT, Avlamis A, et al. Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey. J Antimicrob Chemother 2008;61:59-63.
  • Ikonomidis A, Tokatlidou D, Kristo I, et al. Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a blaVIM-1 Metallo-ß-Lactamase Gene. J Clin Microbiol 2005;43:5344-7.
  • Kassis-Chikhani N, Saliba F, Carbonne A, et al. Extended measures for controlling an outbreak of VIM-1 producing imipenem-resistant Klebsiella pneumoniae in a liver transplant centre in France, 2003–2004. Euro Surveill 2010;15:pii=19713.
  • Loli A, Tzouvelekis LS, Tzelepi E, et al. Sources of diversity of carbapenem resistance levels in Klebsiella pneumoniae carrying blaVIM-1. J Antimicrob Chemother 2006;58:669–72.
  • Fukigai S,Alba J, Kimura S, et al. Nosocomial outbreak of genetically related IMP-1 β-lactamase-producing Klebsiella pneumoniae in a general hospital in Japan. Int J Antimicrob Agents 2007;29:3306-10.
  • Giakkoupi P, Xanthaki A, Kanelopoulou M, et al. VIM-1 Metallo- β -Lactamase-Producing Klebsiella pneumoniae Strains in Greek Hospitals. J Clin Microbiol 2003; 41:3893–6.
  • EARSS Annual Report 2008. On-going surveillance of S. Pneumoniae, S. aureus, E. coli, E. faecium, E. faecalis, K. pneumoniae, P. Aeruginosa. European Centere For Disease and Control (ECDC) 2008.
  • Pitout JD, Nordmann P, Laupland KB, Poirel L. Emergence of Enterobactericeae producing extended-spectrum beta- lactamases (ESBLs) in the community. J Antimicrob Chemother 2005;56:52-9.
  • Poirel L, Nordmann P. Acquired Carbapenem-Hydrolyzing
  • -Lactamases and their Genetic Support - An Update.
  • Medicinal Chemistry Reviews - Online, 2005;2:183-5.
  • Gacar GG, Midilli K, Kolayli F, et al. Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae. Antimicrob Agents Chemother 2005;49:4400-3.
  • Yıldırım I, Ceyhan M, Gür D, Mugnaioli C, Rossolini GM. First detection of VIM-1 type metallo-beta-lactamase in a multidrug-resistant Klebsiella pneumoniae clinical isolate from Turkey also producing the CTX-M-15 extended- spectrum beta-lactamase. J Chemother 2007;19:467-8.
  • Gudiol C, Tubau F, Calatayud L, et al. Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 2011;66:657-63.
  • Meletis G, Tzampaz E, Protonotariou E, Sofianou D. Emergence of Klebsiella pneumoniae carrying blaVIM and blaKPC genes. Hippokratia 2010;14:139–40.
  • Walsh T R, Toleman M A, Poirel L, Nordmann P. Metallo-β- Lactamases: the Quiet before the Storm? Clin Microbiol Reviews 2005;18:306–25.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Nevgün Sepin Özen This is me

Dilara Öğünç This is me

Gözde Öngüt This is me

Derya Seyman This is me

Duygu Dağlar This is me

Betil Özhak Baysan This is me

Dilek Çolak This is me

Volkan Hazar This is me

Thierry Naas This is me

Publication Date August 1, 2014
Published in Issue Year 2014 Volume: 21 Issue: 4

Cite

APA Özen, N. S., Öğünç, D., Öngüt, G., Seyman, D., et al. (2014). Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi. Journal of Turgut Ozal Medical Center, 21(4), 291-293.
AMA Özen NS, Öğünç D, Öngüt G, Seyman D, Dağlar D, Baysan BÖ, Çolak D, Hazar V, Naas T. Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi. J Turgut Ozal Med Cent. August 2014;21(4):291-293.
Chicago Özen, Nevgün Sepin, Dilara Öğünç, Gözde Öngüt, Derya Seyman, Duygu Dağlar, Betil Özhak Baysan, Dilek Çolak, Volkan Hazar, and Thierry Naas. “Antalya Da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae Ye Bağlı Gelişen Bakteremi”. Journal of Turgut Ozal Medical Center 21, no. 4 (August 2014): 291-93.
EndNote Özen NS, Öğünç D, Öngüt G, Seyman D, Dağlar D, Baysan BÖ, Çolak D, Hazar V, Naas T (August 1, 2014) Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi. Journal of Turgut Ozal Medical Center 21 4 291–293.
IEEE N. S. Özen, “Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi”, J Turgut Ozal Med Cent, vol. 21, no. 4, pp. 291–293, 2014.
ISNAD Özen, Nevgün Sepin et al. “Antalya Da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae Ye Bağlı Gelişen Bakteremi”. Journal of Turgut Ozal Medical Center 21/4 (August 2014), 291-293.
JAMA Özen NS, Öğünç D, Öngüt G, Seyman D, Dağlar D, Baysan BÖ, Çolak D, Hazar V, Naas T. Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi. J Turgut Ozal Med Cent. 2014;21:291–293.
MLA Özen, Nevgün Sepin et al. “Antalya Da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae Ye Bağlı Gelişen Bakteremi”. Journal of Turgut Ozal Medical Center, vol. 21, no. 4, 2014, pp. 291-3.
Vancouver Özen NS, Öğünç D, Öngüt G, Seyman D, Dağlar D, Baysan BÖ, Çolak D, Hazar V, Naas T. Antalya da Akut Lenfoblastik Lösemili Hastada VIM-1 Üreten Klebsiella Pneumoniae ye Bağlı Gelişen Bakteremi. J Turgut Ozal Med Cent. 2014;21(4):291-3.