Jüvenil İdiopatik Artritli Çocukların Klinik Ve Laboratuar Özellikleri: Tek Merkez Deneyimi

Year 2013, Volume: 20 Issue: 2, 113 - 118, 01.04.2013

Ahmet Taner Elmas Yılmaz Tabel

Abstract

Giriş: Jüvenil idiyopatik artrit çocukluk çağında sık olarak görülen ve sakatlıklara neden olan heterojen bir hastalık grubudur. Ülkelere göre hastalığın klinik bulgularındaki farklılıklar birçok yayında bildirilmiştir. Gereç ve Yöntemler: Bu çalışmada bölgemizdeki jüvenil idiyopatik artritli çocuk ve adolesan hastaların International League of Associations for Rheumatology ölçütlerine göre sınıflandırılması, değerlendirilmesi ve her bir alt grubun klinik ve laboratuar özelliklerinin karşılaştırılması planlandı. Jüvenil idiyopatik artrit tanısı alan ve en az bir yıl süreyle takip edilen hastaların hastane kayıt dosyaları geriye dönük olarak incelendi. Bulgular: Bu çalışmaya toplam 75 hasta çalışmaya dahil edildi. Hastaların ortanca yaşları 11,0 (7,0–14,0) yıl ve ortanca tanı yaşları 9,0 (5,0–12,0) yıl olarak tespit edildi. Kız/Erkek oranı 1.02 olarak saptandı. Oligoartiküler tip (28 hasta; %37,3) en sık görülen alt grup olarak belirlendi. Çalışmaya dahil olan tüm hastalardaki anti-nükleer antikor pozitifliği oranı %18,6 olarak saptandı. Romatoid faktör pozitifliği en sık romatoid faktör-pozitif poliartiküler tipte saptandı. Tüm jüvenil idiyopatik artrit hastalarındaki üveit görülme oranı %6,6 olarak tespit edildi. Sonuç: Biz bu çalışmada; bölgemizde en sık görülen jüvenil idiyopatik artrit alt tipinin oligoartiküler tip olduğunu; kızlarda ve erkeklerde eşit sıklıkta görüldüğünü tespit ettik. Anti-nükleer antikor pozitifliği oranının %18,6, romatoid faktör pozitifliği oranının %9,3 ve üveit görülme oranının %6,6 olduğunu saptadık. Anahtar kelimeler: Jüvenil İdiyopatik Artrit; International League of Associations for Rheumatology; Çocuklar.

Keywords

Jüvenil İdiyopatik Artrit; International League of Associations for Rheumatology; Çocuklar.

Clinical and Laboratory Characteristics of Children with Juvenil Idiopathic Arthritis: Single-Center Experience

Abstract

Introduction: Juvenile idiopathic arthritis is one of the most common rheumatic diseases of childhood and it is a heterogeneous group of disorders which cause long term disability. Differences in clinical findings of the disease have been reported in many publications from different countries. Material and Methods: In this study, the medical files of the patients who were diagnosed with juvenile idiopathic arthritis and followed up at least one year were evaluated retrospectively. It was aimed to classify and evaluate the juvenile idiopathic arthritis patients according to International League of Associations for Rheumatology classification and to compare clinical and laboratory features of each subgroup. Results: Seventy-five patients were enrolled in the study. The mean age of the patients were 11.0 (7.0–14.0) years and the mean age of the diagnosis of patients were 9.0 (5.0–12.0) years. The ratio of girl/boy was 1.02. Oligoarticular type of juvenile idiopathic arthritis (28 patients, 37.3%) was the most common subgroup. The most common antinuclear antibody positivity was observed in oligoarticular subtype (8 patients, 28.5%) while the most common rheumatoid factor positivity was obtained in rheumatoid factor positive subtype. The anterior uveitis was observed in 6.6% among all patients. Conclusions: In this study, we determined that the oligoarticular onset of juvenile idiopathic arthritis is the most common subtype and we observed with equal frequency in girls and boys in our region. We also observed that the positivity of antinuclear antibody, rheumatoid factor and uveitis were 18.6%, 9.3%, and 6.6%, respectively. Key words: Juvenile Idiopathic Arthritis; International League of Associations for Rheumatology; Children.

Keywords

Juvenile Idiopathic Arthritis; International League of Associations for Rheumatology; Children.

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