BibTex RIS Cite

The Distribution of HLA B27 in Patients with Ankylosing Spondylitis in Eastern Anatolia

Year 2012, Volume: 19 Issue: 1, 23 - 25, 01.02.2012

Eda Diyarbakır Nilnur Eyerci Hülya Uzkeser Saliha Karatay Atilla Topçu Kadir Yıldırım İbrahim Pirim

Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory disease with unknown etiology. Genetic and environmental factors are known to play important roles in the pathogenesis of the disease. A strong association has been detected between AS development and HLA B27. In this study, relationship between HLA B27 and AS in our region has been investigated in the light of literature. In this study, distribution of HLA B27 frequency has been investigated in AS patients classified according to modified New York criteria and in healthy controls. Sequence specific primer polymerase chain reaction (SSP-PCR) technique was used for HLA B27 typing unrelated 84 AS patients and 73 bone marrow volunteer donors. Mean age of AS patients were 31±11 years. In the same group, HLA B27 frequency was found higher in males (39.3%) compared to females (19.0%). HLA B27 positivity was found significantly higher in AS patients (58.3%) when compared the control group (4.3%) (p<0.05). In conclusion, the frequency of HLA-B27 in AS patients observed as higher than healthy subjects. The positivity of HLA-B27 in patient population of Eastern Anatolia is lower than the literature. Further controlled studies are needed to investigate this outcome. Key words: HLA B27; Ankylosing Spondylitis; male

Keywords

-

References

  • Thorsby E. Invited Anniversary Review: HLA Associated Diseases. Hum Immunol 1997; 53: 1-11. DOI: 10.1016/S0198-8859(97)00024-4
  • Khan MA. HLA-B27 and Its Pathogenic Role. J Clin Rheumatol 2008; 14: 50-2. DOI: 10.1097/RHU.0b013e3181637a38
  • Weisman M, Van der Heijde D, Reveille J. Ankylosing Spondylitis and Spondyloathropathies. London: 2008; 10: 121-8.
  • Onen F, Akar S, Birlik M, et al. Prevalence of Ankylosing Spondylitis and Related Spondyloarthritides in an Urban Area of Izmir, Turkey. J Rheumatol 2008; 35: 305-9.
  • Bakland G, Nossent HC, Gran JT. Incidence and Prevalence of Ankylosing Spondylitis in Northern Norway. Arthritis Rheum 2005; 53: 850-5. DOI: 10.1002/art.21577
  • Bodur H, Ataman S, Bugdaycı DS, et al. Description of the Registry of Patients with Ankylosing Spondylitis in Turkey: TRASD-IP. Rheumatol Int 2012; 32:169-76. DOI: 10.1007/s00296-010-1599-7
  • Birinci A, Bilgici A, Kuru O et al. HLA-B27 Polymorphism in Turkish Patients with Ankylosing Spondylitis. Rheumatol Int 2006; 2: 285-7. DOI: 10.1007/s00296-005-0614-x
  • Arnett FC. Ankylosing spondylitis. In: Koopman WJ, (ed).Arthritis and Allied Conditions.A Texbook of Rheumotology. William and Wilkins 1997; 1197-208.
  • Low frequency of HLA-B27 in Ankylosing Spondylitis Patients from Turkey. Joint Bone Spine 2008; 75: 299- 302. DOI: 10.1016/j.jbspin.2007.06.021
  • Bodur H, Ataman S, Bulut L, et al. Characteristics and Medical Management of Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. Clin Rheumatol 2008; 27: 1119-25. DOI: 10.1007/s10067-008-0877-1
  • Ozgocmen S, Ardicoglu O, Kamanlı A, et al. Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis. J Rheumatol 2009; 36: 2830-3. DOI: 10.3899/jrheum.090435
  • Khan MA, Ball EJ. Genetic Aspects of Ankylosing Spondylitis. Best Pract Res Clin Rheumatol 2002; 16: 675- 90.
  • Feldtkeller E, Khan MA, Van der Heijde D, et al. Age at Disease Onset and Diagnosis Delay in HLA-B27 Negative vs. Positive Patients with Ankylosing Spondylitis. Rheumatol Int 2003; 23: 61-6.
  • Bhatia K, Prasad ML, Barnish G, et al. Antigen and Haplotype Frequencies at 3 Human-Leukocyte Antigen Loci (HLA-A, HLA-B, HLA-C) in the Pawaia of Papua- New-Guinea. Am J Physical Anthropol 1988; 75: 329-40. DOI: 10.1002/ajpa.1330750304
  • Gul A, Uyar FA, Inanc M, et al. A Weak Association of HLA-B*2702 with Behcet's Disease. Genes Immun 2002; 3: 368-72.
  • Sieper J, Rudwaleit M, Khan MA, et al. Concepts and Epidemiology of Spondyloarthritis. Best Pract Res Clin Rheumatol 2006; 20: 401-17. DOI: 10.1016/j.berh.2006.02.001
  • Chen HH, Chen TJ, Chen YM, et al. Gender Differences in Ankylosing Spondylitis-Associated Cumulative Healthcare Utilization: A Population-Based Cohort Study. Clinics (Sao Paulo) 2001; 66: 251-4. DOI: 10.1590/S1807- 59322011000200012
  • How to cite this article: Diyarbakır E, Eyerci N,
  • Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ.
  • The Distribution of HLA B27 in Patients with
  • Ankylosing Spondylitis in Eastern Anatolia. JIUMF 2012; 19(1): 23-5.
  • DOI: 10.7247/jiumf.2012.19.1.23_25

Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı

Year 2012, Volume: 19 Issue: 1, 23 - 25, 01.02.2012

Eda Diyarbakır Nilnur Eyerci Hülya Uzkeser Saliha Karatay Atilla Topçu Kadir Yıldırım İbrahim Pirim

Abstract

Ankilozan spondilit (AS) etyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. Patogenezde genetik ve çevresel faktörlerin önemli rol oynadığı bilinmektedir. AS gelişimi ile HLA B27 arasında güçlü bir birliktelik saptanmıştır. Bu çalışma ile daha önceki literatür bilgileri ışığında bölgemizdeki HLA B27-AS ilişkisi karşılaştırıldı. Bu çalışmada, modifiye New York kritelerine göre sınıflandırılmış AS'li hasta ve sağlıklı kontroller üzerinde HLA B27 frekansı araştırılmıştır. Çalışmaya birbirleri ile akraba olmayan 84 AS'li hasta ile 73 gönüllü kemik iliği donörü dahil edildi. HLA B27 tiplendirilmesi PCR-SSP yöntemi ile belirlendi. Elde edilen bulgulara göre çalışmaya alınan AS'li hastaların yaş ortalaması 31±11yıl olarak bulundu. Aynı grupta erkeklerde (%39.3) HLA B27 frekansı kadınlardan (%19.0) çok daha yüksekti. Ankilozan spondilitli hastalar (%58,3) ile kontrol grubu (%4.3) karşılaştırıldığında hasta grubunda HLA B27 pozitifliğinin yüksek olduğu görüldü (p<0.05). Sonuç olarak AS hastalarında HLA B27 frekansının sağlıklı bireylerden daha yüksek olduğu görülmektedir. Doğu Anadolu Bölgesinin hasta populasyonunda HLA B27 pozitifliği, literatürde verilen diğer oranlardan daha düşük olabilir. Bu durumu inceleyecek yeni klinik çalışmaların yapılması faydalı olacaktır. Anahtar Sözcükler: HLA B27; Ankilozan Spondilit; erkek

Keywords

-

References

  • Thorsby E. Invited Anniversary Review: HLA Associated Diseases. Hum Immunol 1997; 53: 1-11. DOI: 10.1016/S0198-8859(97)00024-4
  • Khan MA. HLA-B27 and Its Pathogenic Role. J Clin Rheumatol 2008; 14: 50-2. DOI: 10.1097/RHU.0b013e3181637a38
  • Weisman M, Van der Heijde D, Reveille J. Ankylosing Spondylitis and Spondyloathropathies. London: 2008; 10: 121-8.
  • Onen F, Akar S, Birlik M, et al. Prevalence of Ankylosing Spondylitis and Related Spondyloarthritides in an Urban Area of Izmir, Turkey. J Rheumatol 2008; 35: 305-9.
  • Bakland G, Nossent HC, Gran JT. Incidence and Prevalence of Ankylosing Spondylitis in Northern Norway. Arthritis Rheum 2005; 53: 850-5. DOI: 10.1002/art.21577
  • Bodur H, Ataman S, Bugdaycı DS, et al. Description of the Registry of Patients with Ankylosing Spondylitis in Turkey: TRASD-IP. Rheumatol Int 2012; 32:169-76. DOI: 10.1007/s00296-010-1599-7
  • Birinci A, Bilgici A, Kuru O et al. HLA-B27 Polymorphism in Turkish Patients with Ankylosing Spondylitis. Rheumatol Int 2006; 2: 285-7. DOI: 10.1007/s00296-005-0614-x
  • Arnett FC. Ankylosing spondylitis. In: Koopman WJ, (ed).Arthritis and Allied Conditions.A Texbook of Rheumotology. William and Wilkins 1997; 1197-208.
  • Low frequency of HLA-B27 in Ankylosing Spondylitis Patients from Turkey. Joint Bone Spine 2008; 75: 299- 302. DOI: 10.1016/j.jbspin.2007.06.021
  • Bodur H, Ataman S, Bulut L, et al. Characteristics and Medical Management of Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. Clin Rheumatol 2008; 27: 1119-25. DOI: 10.1007/s10067-008-0877-1
  • Ozgocmen S, Ardicoglu O, Kamanlı A, et al. Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis. J Rheumatol 2009; 36: 2830-3. DOI: 10.3899/jrheum.090435
  • Khan MA, Ball EJ. Genetic Aspects of Ankylosing Spondylitis. Best Pract Res Clin Rheumatol 2002; 16: 675- 90.
  • Feldtkeller E, Khan MA, Van der Heijde D, et al. Age at Disease Onset and Diagnosis Delay in HLA-B27 Negative vs. Positive Patients with Ankylosing Spondylitis. Rheumatol Int 2003; 23: 61-6.
  • Bhatia K, Prasad ML, Barnish G, et al. Antigen and Haplotype Frequencies at 3 Human-Leukocyte Antigen Loci (HLA-A, HLA-B, HLA-C) in the Pawaia of Papua- New-Guinea. Am J Physical Anthropol 1988; 75: 329-40. DOI: 10.1002/ajpa.1330750304
  • Gul A, Uyar FA, Inanc M, et al. A Weak Association of HLA-B*2702 with Behcet's Disease. Genes Immun 2002; 3: 368-72.
  • Sieper J, Rudwaleit M, Khan MA, et al. Concepts and Epidemiology of Spondyloarthritis. Best Pract Res Clin Rheumatol 2006; 20: 401-17. DOI: 10.1016/j.berh.2006.02.001
  • Chen HH, Chen TJ, Chen YM, et al. Gender Differences in Ankylosing Spondylitis-Associated Cumulative Healthcare Utilization: A Population-Based Cohort Study. Clinics (Sao Paulo) 2001; 66: 251-4. DOI: 10.1590/S1807- 59322011000200012
  • How to cite this article: Diyarbakır E, Eyerci N,
  • Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ.
  • The Distribution of HLA B27 in Patients with
  • Ankylosing Spondylitis in Eastern Anatolia. JIUMF 2012; 19(1): 23-5.
  • DOI: 10.7247/jiumf.2012.19.1.23_25
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Eda Diyarbakır This is me

Nilnur Eyerci This is me

Hülya Uzkeser This is me

Saliha Karatay This is me

Atilla Topçu This is me

Kadir Yıldırım This is me

İbrahim Pirim This is me

Publication Date February 1, 2012
Published in Issue Year 2012 Volume: 19 Issue: 1

Cite

APA Diyarbakır, E., Eyerci, N., Uzkeser, H., Karatay, S., et al. (2012). Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı. Journal of Turgut Ozal Medical Center, 19(1), 23-25.
AMA Diyarbakır E, Eyerci N, Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ. Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı. J Turgut Ozal Med Cent. February 2012;19(1):23-25.
Chicago Diyarbakır, Eda, Nilnur Eyerci, Hülya Uzkeser, Saliha Karatay, Atilla Topçu, Kadir Yıldırım, and İbrahim Pirim. “Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı”. Journal of Turgut Ozal Medical Center 19, no. 1 (February 2012): 23-25.
EndNote Diyarbakır E, Eyerci N, Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ (February 1, 2012) Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı. Journal of Turgut Ozal Medical Center 19 1 23–25.
IEEE E. Diyarbakır, N. Eyerci, H. Uzkeser, S. Karatay, A. Topçu, K. Yıldırım, and İ. Pirim, “Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı”, J Turgut Ozal Med Cent, vol. 19, no. 1, pp. 23–25, 2012.
ISNAD Diyarbakır, Eda et al. “Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı”. Journal of Turgut Ozal Medical Center 19/1 (February 2012), 23-25.
JAMA Diyarbakır E, Eyerci N, Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ. Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı. J Turgut Ozal Med Cent. 2012;19:23–25.
MLA Diyarbakır, Eda et al. “Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı”. Journal of Turgut Ozal Medical Center, vol. 19, no. 1, 2012, pp. 23-25.
Vancouver Diyarbakır E, Eyerci N, Uzkeser H, Karatay S, Topçu A, Yıldırım K, Pirim İ. Doğu Anadolu Bölgesinde Ankilozan Spondilitli Hastalarda HLA B27 Frekansının Dağılımı. J Turgut Ozal Med Cent. 2012;19(1):23-5.