BibTex RIS Cite

Comparing the HbA1c levels in Type 2 Diabetes Mellitus Discase and Brain Stem Odyometry and The Role in Prognoais

Year 2011, Volume: 18 Issue: 4, 215 - 221, 01.08.2011

Abstract

Introduction: Most recently, it was accepted that diabetes mellitus (DM) is the most important disease from the point of view mortality and morbidity. It is possible to determine subclinic neuropathy recording Auditory Brainstem Response (ABR) to avoid complication of DM. If it is determined pahtological condition on the ABR recording, it must be followed more tightly serum glucose levels of patients and it must be avoided especially hipoglisemia and ketoasidosis. It can be obtained information about last three monthly blood glucose controlling HbA1c levels of patients together with fasting blood glucose following in the outpatient controls. It should not give permission excessive undolation of blood glucose patients must be recorded assaying several times their blood glucose. It is important that ABR records of patients must be compared according to ages repeating with spesific intervals. Materials and Methods: In our study, it was compared evoked brainstem responces with serum HbA1c levels of 30 patients with Diabetes Mellitus and 30 control group patients when working groups compared with respect whether I, III and V wave latences. Results: No statistical difference was found between groups that examined. It was observed smilar results to our study, it was determined clear axtend on the patients with neuropathy. Statistically significance was found between diabetes period and serum HbA1c levels with wave latences (p<0.05) but no difference was found in diabetes period when compare to the serum HbA1c levels in the literature. Conclusion: Diabetes Mellitus is the disease showing a latent period before complications of DM and it is possible to determine complications of DM using electrophysiological tests in this period and to take measures. For this reason, ABR can provide a good monitorisation. Key words: Diabetes mellitus, HbA1c, ABR, BERA, Odiometry.

References

  • Braunwald E, Fauchi A, Kasper D, Hauser D, Lango DL, Jamesson J. Harrison 2004; 2: 2109-37.
  • Stanton SG, Ryerson E, Moore SL, Sullivan-Mahoney M, Couch SC. Hearing screening outcomes in infants of pregestational diabetic mothers. Am J Audiol 2005; 14(1):86-93.
  • Hosono T, Suzuki M, Chiba Y. Contraindication of magnesium sulfate in a pregnancy complicated with late-onset diabetes mellitus and sensory deafness due to mitochondrial myopathy. J Matern Fetal Med 2001; 10(5): 355-56.
  • Konrad-Martin D, Austin DF, Griest S, McMillan GP, McDermott D, Fausti S. Diabetes-related changes in auditory brainstem responses. Laryngoscope 2010; 120(1): 150-58.
  • Wang CT, Huang TW, Kuo SW, Cheng PW. Correlation between audiovestibular function tests and hearing outcomes in severe to profound sudden sensorineural hearing loss. Ear Hear 2009; 30(1): 110-14.
  • Wilson JD, Moore G. Successful pregnancy in the DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, deafness). Aust N Z J Obstet Gynaecol 1995; 35(1): 100-1.
  • Wiegrad AL., Morrison AD, Grena DA. In textbook of Endocrinology De Groot L.J 1989; 11: 1041-55.
  • Clements RS, Bell DS. Diabetic neuropaty, peripheral and autonomic syndromes. Postgraduate Med 1982; 70: 50-67.
  • De Bresser J, Reijmer YD, van den Berg E, Breedijk MA, Kappelle LJ, Viergever MA, Biessels GJ. Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes. Dement Geriatr Cogn Disord 2010; 30(5): 381-6. Epub 2010 Oct 21.
  • Liapi C, Kyriakaki A, Zarros A, et al. S.Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. Metab Brain Dis 2010; 25(3): 69-76. Epub 2010 Sep 14.
  • Reske-Nielsen E, Lunbaek K. Diabetic encephalophaty diffuse and focal lesions of the brain in long term diabetes, Acta Neurol Scand 1973; 39(Supp1:4)273-90.
  • De Jong RN. CNS manifestations of diabetes mellitus. Postgrad Med 1997; 61: 46-51.
  • Winegrad AL, Morrison AD, Grene DA. In textbook of Endocrinology (Eds) De Groot L.J 1979; 11: 1041-55.
  • Aronson SM. Intracranial vascular lesions in patients with diabetes mellitus J Neuropahol Exp eurol 1973; 32(2): 182-196.
  • Khardori R, Soler NG, Good DC, Howard AB, Broughton D, Walbert J. Brainstem auditory and visual evoked potentials in type 1 (insulin dependent) diabetic paients. Diabetologia 1986; 29: 362-65.
  • Woltman HW, Wilder RM. Diabetes mellitus. Pathological changes in the spinal cord and peripheral nerves. Arch Intern Med 1989; 44: 576-603
  • Verma A, Bisth MS, Ahuja GK. Involvement of central nervous system in diabetes mellitus. J Neurol Neurosurg Psych 1984; 47: 414-6.
  • Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH. Cerebral function in diabetes mellius. Diabetologia 1994; 37: 643-50.
  • Hall JW, Brown DP, Mochey J. Pediatric applications of serial audiory brainstem and middle latency evoked response recordings Int J Ped Otorhinolaryngology 1985; 9: 201-218.
  • Donald MW, Bird CE, Lawson JS. Delayed auditory brainstem responses in diabetes mellitus, J Neurol Neurosurg Psych 1981; 44: 641-44.
  • Goldsher M, Prat H, Hassan H, Shenav R, Eliacher I, Kanter Y. Auditory brainstem evoked potantials in insulin-dependent diabetes with and without peripheral neuropathy. Acta. otolaryngol 1986; 102: 204-5.
  • Uçar HC. Diabetes mellitusun prognozunun tayininde işitsel beyin sapı cevaplarının yeri. Uzmanlık tezi Gata Ankara 1992.
  • Ottaviani F, Dozio N, Neglia c, Riccio S, Scavini M. Absence of otoacoustic emissions in insulin-dependent diabetic patients is there evidence for diabetic oculopathy: Journal of Diabetes Compl 2002; 16:338-43.
  • Bayazıt Y, Yılmaz M, Kepekçi Y, Mumbuç S, Kanlıkama M. Use of the auditory brainstem response testing in the clinial evaluation of the patients with diabetes mellitus: Neurol Sci 2000; 181: 29-32.
  • Weng SF, Chen YS, Hsu CJ, Tseng FY. Clinial features of sudden sensorineural hearing loss in diabetic patients: Laryngoscope 2005; 115.
  • Buller N, Shvili Y, Şaurian N et al. Delayed brain stem auditory evoked responses in diabetic patients. J Laryngol Otolaryngol 1988; 102: 857-60.
  • Fedelle D, Martini A, Cardone A, et al. Impaired auditory brainstem-evoked responses in insulin-dependent diabetes subjects Diabetes1984; 33: 1085-89.
  • Virtaniemi J, Kuusisto J, Karjalainen L. Improvement of metabolic control does not normalize auditory brain stem latencies in subjects with insulin dependent diabetes mellitus. Am J Otolaryngol 1995; 16: 172-76.
  • Martini A, Comacchio F, Magnavita V. Auditory brainstem and middle latency evoked responses in the clinical evalauation of diabetes. Diabetes 1997; 8: 74-77.
  • Berlin CI, Morlet T, Hood LJ. Auditory neuropathy/dyssynchrony: its diagnosis and management. Pediatr Clin North Am 2003; 50(2):331-40.
  • Rodbard D. Clinical interpretation of indices of quality of glycemic control and glycemic variability. Postgrad Med 2011;123(4): 107-18.

Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri

Year 2011, Volume: 18 Issue: 4, 215 - 221, 01.08.2011

Abstract

Giriş: Son yüzyılda diabetes mellitus (DM) mortalite ve morbidite açısından en önemli hastalıklardan biri olmuştur. Diabetes mellitusun komplikasyonlarından korunmak için subklinik nörapatiyi düzenli aralıkla Auditory Brainstem Response (ABR) kaydı yaparak tespit etmek mümkündür. ABR kaydında herhangi bir patoloji saptanırsa hastaların kan şekeri daha sıkı takip edilmeli ve hastalar özellikle hipoglisemi ve ketoasidozdan korunmalıdır. Materyal-Metod: Poliklinik kontrollerinde hastaların açlık kan şekeri takibi yanı sıra kan HbA1c kontrolleri yapılarak son 3 aylık kan şekeri hakkında bilgi sahibi olunabilir. Hastaların kan şekerindeki aşırı dalgalanmalara izin verilmemeli mümkünse hastalar evde kendileri kan şekerlerini günde birkaç defa ölçerek kaydetmelidirler. Hastaların yaşlarına göre ABR kayıtlarının karşılaştırması yapılarak belirli aralıklarla tekrarlanması hastaların monitörizasyonu açısından çok önemlidir. Bulgular: Çalışmamızda diabetes mellituslu 30 hasta ile 30 kontrol gurubunun kan HbA1c düzeyleri ile uyarlanmış beyin sapı cevapları karşılaştırılmıştır. Her iki grup arasında I, III ve V dalga latansları ile I-III, I-V ve III-V interpik dalga latansları arasında istatistiksel olarak kayda değer fark bulunmamıştır. Litaratürde de benzer şekilde sonuçlar elde edilmiştir; fakat nöropati olan hastalarda belirgin uzama saptanmıştır. Ayrıca biz diabet süresi ve kan HbA1c düzeyi ile dalga latansları arasında kayda değer ilgi saptamışken (p<0.05) literatürde diabet süresi ve kan Hb A1c ile kayda değer ilgi saptanmamıştır. Sonuç: Sonuç olarak diabet komplikasyon yapmadan önce latent bir period gösterir ve bu periodda elektrofizyolojik testlerle olası komplikasyonlar önceden tespit edilebilir ve önceden tedbir alınabilir. ABR bu nedenle iyi bir monitorizasyon sağlayabilir. Anahtar kelimeler: Diabetes mellitus, HbA1c, ABR, BERA, Odyometri.

References

  • Braunwald E, Fauchi A, Kasper D, Hauser D, Lango DL, Jamesson J. Harrison 2004; 2: 2109-37.
  • Stanton SG, Ryerson E, Moore SL, Sullivan-Mahoney M, Couch SC. Hearing screening outcomes in infants of pregestational diabetic mothers. Am J Audiol 2005; 14(1):86-93.
  • Hosono T, Suzuki M, Chiba Y. Contraindication of magnesium sulfate in a pregnancy complicated with late-onset diabetes mellitus and sensory deafness due to mitochondrial myopathy. J Matern Fetal Med 2001; 10(5): 355-56.
  • Konrad-Martin D, Austin DF, Griest S, McMillan GP, McDermott D, Fausti S. Diabetes-related changes in auditory brainstem responses. Laryngoscope 2010; 120(1): 150-58.
  • Wang CT, Huang TW, Kuo SW, Cheng PW. Correlation between audiovestibular function tests and hearing outcomes in severe to profound sudden sensorineural hearing loss. Ear Hear 2009; 30(1): 110-14.
  • Wilson JD, Moore G. Successful pregnancy in the DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, deafness). Aust N Z J Obstet Gynaecol 1995; 35(1): 100-1.
  • Wiegrad AL., Morrison AD, Grena DA. In textbook of Endocrinology De Groot L.J 1989; 11: 1041-55.
  • Clements RS, Bell DS. Diabetic neuropaty, peripheral and autonomic syndromes. Postgraduate Med 1982; 70: 50-67.
  • De Bresser J, Reijmer YD, van den Berg E, Breedijk MA, Kappelle LJ, Viergever MA, Biessels GJ. Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes. Dement Geriatr Cogn Disord 2010; 30(5): 381-6. Epub 2010 Oct 21.
  • Liapi C, Kyriakaki A, Zarros A, et al. S.Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. Metab Brain Dis 2010; 25(3): 69-76. Epub 2010 Sep 14.
  • Reske-Nielsen E, Lunbaek K. Diabetic encephalophaty diffuse and focal lesions of the brain in long term diabetes, Acta Neurol Scand 1973; 39(Supp1:4)273-90.
  • De Jong RN. CNS manifestations of diabetes mellitus. Postgrad Med 1997; 61: 46-51.
  • Winegrad AL, Morrison AD, Grene DA. In textbook of Endocrinology (Eds) De Groot L.J 1979; 11: 1041-55.
  • Aronson SM. Intracranial vascular lesions in patients with diabetes mellitus J Neuropahol Exp eurol 1973; 32(2): 182-196.
  • Khardori R, Soler NG, Good DC, Howard AB, Broughton D, Walbert J. Brainstem auditory and visual evoked potentials in type 1 (insulin dependent) diabetic paients. Diabetologia 1986; 29: 362-65.
  • Woltman HW, Wilder RM. Diabetes mellitus. Pathological changes in the spinal cord and peripheral nerves. Arch Intern Med 1989; 44: 576-603
  • Verma A, Bisth MS, Ahuja GK. Involvement of central nervous system in diabetes mellitus. J Neurol Neurosurg Psych 1984; 47: 414-6.
  • Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH. Cerebral function in diabetes mellius. Diabetologia 1994; 37: 643-50.
  • Hall JW, Brown DP, Mochey J. Pediatric applications of serial audiory brainstem and middle latency evoked response recordings Int J Ped Otorhinolaryngology 1985; 9: 201-218.
  • Donald MW, Bird CE, Lawson JS. Delayed auditory brainstem responses in diabetes mellitus, J Neurol Neurosurg Psych 1981; 44: 641-44.
  • Goldsher M, Prat H, Hassan H, Shenav R, Eliacher I, Kanter Y. Auditory brainstem evoked potantials in insulin-dependent diabetes with and without peripheral neuropathy. Acta. otolaryngol 1986; 102: 204-5.
  • Uçar HC. Diabetes mellitusun prognozunun tayininde işitsel beyin sapı cevaplarının yeri. Uzmanlık tezi Gata Ankara 1992.
  • Ottaviani F, Dozio N, Neglia c, Riccio S, Scavini M. Absence of otoacoustic emissions in insulin-dependent diabetic patients is there evidence for diabetic oculopathy: Journal of Diabetes Compl 2002; 16:338-43.
  • Bayazıt Y, Yılmaz M, Kepekçi Y, Mumbuç S, Kanlıkama M. Use of the auditory brainstem response testing in the clinial evaluation of the patients with diabetes mellitus: Neurol Sci 2000; 181: 29-32.
  • Weng SF, Chen YS, Hsu CJ, Tseng FY. Clinial features of sudden sensorineural hearing loss in diabetic patients: Laryngoscope 2005; 115.
  • Buller N, Shvili Y, Şaurian N et al. Delayed brain stem auditory evoked responses in diabetic patients. J Laryngol Otolaryngol 1988; 102: 857-60.
  • Fedelle D, Martini A, Cardone A, et al. Impaired auditory brainstem-evoked responses in insulin-dependent diabetes subjects Diabetes1984; 33: 1085-89.
  • Virtaniemi J, Kuusisto J, Karjalainen L. Improvement of metabolic control does not normalize auditory brain stem latencies in subjects with insulin dependent diabetes mellitus. Am J Otolaryngol 1995; 16: 172-76.
  • Martini A, Comacchio F, Magnavita V. Auditory brainstem and middle latency evoked responses in the clinical evalauation of diabetes. Diabetes 1997; 8: 74-77.
  • Berlin CI, Morlet T, Hood LJ. Auditory neuropathy/dyssynchrony: its diagnosis and management. Pediatr Clin North Am 2003; 50(2):331-40.
  • Rodbard D. Clinical interpretation of indices of quality of glycemic control and glycemic variability. Postgrad Med 2011;123(4): 107-18.
There are 31 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Volkan Türünz This is me

Faruk Meriç This is me

İsmail Topçu This is me

Publication Date August 1, 2011
Published in Issue Year 2011 Volume: 18 Issue: 4

Cite

APA Türünz, V., Meriç, F., & Topçu, İ. (2011). Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri. Journal of Turgut Ozal Medical Center, 18(4), 215-221.
AMA Türünz V, Meriç F, Topçu İ. Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri. J Turgut Ozal Med Cent. August 2011;18(4):215-221.
Chicago Türünz, Volkan, Faruk Meriç, and İsmail Topçu. “Tip 2 Diabetes Mellitusta HbA1c Düzeyi Ile Beyin Sapı Odyometrisinin Karşılaştırılması Ve Prognoz Tayinindeki Yeri”. Journal of Turgut Ozal Medical Center 18, no. 4 (August 2011): 215-21.
EndNote Türünz V, Meriç F, Topçu İ (August 1, 2011) Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri. Journal of Turgut Ozal Medical Center 18 4 215–221.
IEEE V. Türünz, F. Meriç, and İ. Topçu, “Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri”, J Turgut Ozal Med Cent, vol. 18, no. 4, pp. 215–221, 2011.
ISNAD Türünz, Volkan et al. “Tip 2 Diabetes Mellitusta HbA1c Düzeyi Ile Beyin Sapı Odyometrisinin Karşılaştırılması Ve Prognoz Tayinindeki Yeri”. Journal of Turgut Ozal Medical Center 18/4 (August 2011), 215-221.
JAMA Türünz V, Meriç F, Topçu İ. Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri. J Turgut Ozal Med Cent. 2011;18:215–221.
MLA Türünz, Volkan et al. “Tip 2 Diabetes Mellitusta HbA1c Düzeyi Ile Beyin Sapı Odyometrisinin Karşılaştırılması Ve Prognoz Tayinindeki Yeri”. Journal of Turgut Ozal Medical Center, vol. 18, no. 4, 2011, pp. 215-21.
Vancouver Türünz V, Meriç F, Topçu İ. Tip 2 Diabetes Mellitusta HbA1c Düzeyi ile Beyin Sapı Odyometrisinin Karşılaştırılması ve Prognoz Tayinindeki Yeri. J Turgut Ozal Med Cent. 2011;18(4):215-21.