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Slime Faktörünün Klinikteki Yeri Ve Önemi

Year 2006, Volume: 13 Issue: 3, 193 - 197, 01.06.2006

S. Aslıhan Cengiz Ebru Us A. Tevfik Cengiz

Abstract

Bu derlemede koagülaz negatif stafilokoklar (KNS) ve Candida kökenlerinde slime faktör üretimi ve bu faktörün klinik önemi üzerinde durulmuştur. Slime faktörün özellikleri ve tesbit yöntemleri açıklanmış, adezyonu etkileyen çeşitli faktörler üzerinde durulmuştur. Bu arada biyofilmin yapısı, virulans üzerine etkisi etraflı bir şekilde gözden geçirilmiştir. Anahtar kelimeler: Koagülaz negatif stafilokok, Candida, Slime faktörü, Biyofilm, Adezyon

Keywords

Koagülaz negatif stafilokok Candida Slime faktörü Biyofilm Adezyon

References

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  • Baillie GS, Douglas LJ. Effect of growth rate on resistance of Candida albicans biofilms to antifungal agents. Antimicrob Agents Chemother. 1998; 42:1900-5.
  • Bachmann SP, VandeWalle K, Ramage G, Patterson TF, Wickes BL, Graybill JR, Lopez-Ribot JL. In vitro activity of caspofungin against Candida albicans biofilms. Antimicrob Agents Chemother. 2002;46:3591-6.
  • Douglas LJ. Candida biofilms and their role in infection. Trends Microbiol. 2003;11:30-6.
  • Potera C. Forging a link between biofilms and disease. Science. 1999;283:1837-9.
  • Jansen B, Schumacher-Perdreau F, Peters G, Pulverer G. New aspects in the pathogenesis and prevention of polymer-associated foreign-body infections caused by coagulase-negative staphylococci. J Invest Surg. 1989; 2:361-80.
  • Kocazeybek B, Çakan H, Ayyıldız A, Küçükateş E, Gülsoy Ö, Ordu A. Cerrahi yoğun bakım ünitesinden izole edilen koagülaz negatif stafilokoklarda slime faktörü oluşturma ve bunların kemoterapötiklere dirençle ilişkisinin araştırılması. Ankem Derg. 200; 4:683-9.
  • Kalkancı A, Çırak Yalınay M, Mansuroğlu H, Kuştimur S. Candida türlerinde slime faktör belirlenmesi. Türk Mikrobiyol Cem Derg. 1999; 29:183-5.
  • Orhon H, Özbakkaloğlu B, Sürücüoğlu S, Tünger Ö, Arısoy AS. İnfeksiyon etkeni olan Candida albicans suşlarında slime üretimi ve antifungal ajanlara duyarlılıkları. Türk Mikrobiyol Cem Derg. 1998;28:103-6.
  • Karaca N, Koç AN, Karagöz S. Kan ve vajen örneklerinden izole edilen Candida türlerinin slime aktiviteleri. Türk Mikrobiyol Cem Derg. 2001;31:224-6.
  • Cengiz SA. Koagülaz negatif stafilokoklar. Tıp ve Diş Hekimliğinde Genel ve Özel Mikrobiyoloji. Cengiz AT, editör. Ankara: Güneş Kitabevi 2004: 351-60.
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  • Kotilainen P. Association of coagulase-negative staphylococcal slime production and adherence with the development and outcome of adult septicemias. J Clin Microbiol. 1990; 28:2779-85.
  • Christensen GD, Simpson WA, Younger JJ, Baddour LM, Barrett FF, Melton DM, Beachey EH. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol. 1985;22:996-1006.
  • Christensen GD, Simpson WA, Bisno AL, Beachey EH. Adherence of slime- producing strains of Staphylococcus epidermidis to smooth surfaces. Infect Immun. 1982;37:318-26.
  • Christensen GD, Baldassari L, Simpson WA. Colonization of medical devices by coagulase-negative staphylococci. Bisno A, Waldvogel FA, editors. Infections associated with indwelling Medical devices. 2 nd ed. Washington DC: ASM Press 1994: 45-78.
  • Deighton MA, Balkau B. Adherence measured by microtiter assay as a virulence marker for Staphylococcus epidermidis infections. J Clin Microbiol. 1990;28:2442-7.
  • Younger JJ, Christensen GD, Bartley DL, Simmons JC, Barrett FF. Coagulase- negative staphylococci isolated from cerebrospinal fluid shunts: importance of slime production, species identification, and shunt removal to clinical outcome. J Infect Dis. 1987;156:548-54
  • Freeman DJ, Falkiner FR, Keane CT. New method for detecting slime production by coagulase negative staphylococci. J Clin Pathol. 1989;42:872-4.
  • Aydınlı A, Durmaz G, Akgün Y. Koagülaz negatif stafilokoklarda slime faktör yapımının kongo kırmızılı agar yöntemi ile araştırılması. Flora.1997; 1:41-4.
  • Kaleli İ, Demir M. Koagülaz negatif stafilokoklarda slime faktör yapımının iki ayrı yöntem ile ve farklı atmosfer ortamlarında araştırılması. Türkiye Tıp Dergisi. 1999; 6:226-30.
  • Kiraz N. Koagülaz negatif stafilokokların “Slime” oluşturmaları ve bazı antibiyotiklerin “Slime” oluşumuna etkileri. Türk Mikrobiyol Cem Derg. 1993; 23: 219-25.
  • The gram-positive cocci: Part-1: Staphylococci and related organisms. Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Win WC, editors. In: Color Atlas and Textbook of Diagnostic Microbiology. 5 th ed. Philadelphia: JB Lippincott Company 1997: 539-76.
  • Denyer SP, Davies MC, Evans JA, Finch RG, Smith DG, Wilcox MH, Williams P. Influence of carbon dioxide on the surface characteristics and adherence potential of coagulase-negative staphylococci. J Clin Microbiol. 1990;28:1813-7.
  • Barker LP, Simpson WA, Christensen GD. Differential production of slime under aerobic and anaerobic conditions. J Clin Microbiol. 1990; 28:2578-9.
  • Songür M, Sayan M, Yüce A, Yuluğ N. Koagülaz negatif stafilokoklarda slime üretimi ile değişik inkübasyon ortamlarının ilişkisi. İnfeksiyon Dergisi. 1998;12: 29-33.
  • el-Azizi M, Khardori N. Factors influencing adherence of Candida spp. to host tissues and plastic surfaces.Indian J Exp Biol. 1999;37:941-51.
  • Costa Pires MF, Correa B, Gambale W, Rodrigues Paula C. Experimental model of Candida albicans (serotype A and B) adherence in vitro. Brazil J Microbiol. 2001; 32:163-69.
  • Cotter G, Kavanagh K. Adherence mechanisms of Candida albicans. Br J Biomed Sci. 2000;57:241-9.
  • Ollert MW, Sohnchen R, Korting HC, Ollert U, Brautigam S, Brautigam W. Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun. 1993;61:4560-8.
  • Warren WG, Hazen KC. Candida, Cryptococus and other yeasts of medical importance. In: Murray PR, Baron EJ, Pfaller MA, Jorgensen JH, Yolken RH, editors. Manual of Clinical Microbiology. 8th ed.Washington, DC: ASM press 2003: 1693-711.
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  • Abu-Elteen KH, Abu-Alteen RM. The prevalence of Candida albicans populations in the mouths of complete denture wearers. New Microbiol. 1998;21:41-8.
  • Ben-Aryeh H, Blumfield E, Szargel R, Laufer D, Berdicevsky I. Oral Candida carriage and blood group antigen secretor status. Mycoses. 1995;38:355-8.
  • Gökdal İ, Kalkancı A, Paçal G, Altuğ Z. Ortodontik braketlerin yüzeyinde Candida kolonizasyonu ve bu Candida albicans suşlarının agız içi epitel hücrelerine adezyonu. Mikrobiyol Bült. 2002;36:65-9.
  • Sundstrom P. Adhesion in Candida spp. Cell Microbiol. 2002; 4: 461-9.
  • Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol. 2001;183:5385-94.
  • Kamagata-Kiyoura Y, Abe S, Yamaguchi H, Nitta T. Detachment activity of human saliva in vitro for Candida albicans cells attached to a plastic plate. J Infect Chemother. 2003;9:215-20.
  • Fukazawa Y, Kagaya K. Molecular bases of adhesion of Candida albicans. J Med Vet Mycol. 1997;35:87-99.
  • Calderone RA, Braun PC. Adherence and receptor relationships of Candida albicans. Microbiol Rev. 1991;55:1-20.
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  • Kalkancı A, Kuştimur S. Candida albicans’ın konak hücreye adezyonu ve klinik önemi. İnfek Derg. 2004; 18:373-80.
  • Branchini ML, Pfaller MA, Rhine-Chalberg J, Frempong T, Isenberg HD. Genotypic variation and slime production among blood and catheter isolates of Candida parapsilosis. J Clin Microbiol. 1994;32:452-6.
  • Pfaller M, Davenport D, Bale M, Barrett M, Koontz F, Massanari RM. Development of the quantitative micro-test for slime production by coagulase-negative staphylococci. Eur J Clin Microbiol Infect Dis. 1988;7:30-3.
  • Hilmioğlu S, İlkit M, Çavuşoğlu C, Aydemir Ş, Tümbay E. Candida kökenlerinde Slaym (Slime) üretiminin üç ayrı yöntemle gösterilmesi ve slaym üretiminin kristal viyole reaksiyonu ile ilişkisi. İnfek Derg.1999;13: 183-6.
  • Arslan U, Fındık D. Klinik örneklerden izole edilen Candida albicans türü maya mantarlarında virulans faktörlerinin (proteinaz, slime ve fosfolipaz) in-vitro araştırılması. İnfek Derg. 2003;17:471-81.
  • Kuştimur S. Kandida patojenezinde rol oynayan faktörler. Mikrobiyol Bült. 1994;28:175-81.
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The Clinical Importance of Slime Productıon

Year 2006, Volume: 13 Issue: 3, 193 - 197, 01.06.2006

S. Aslıhan Cengiz Ebru Us A. Tevfik Cengiz

Abstract

In this review, we emphasize the importance of slime production of coagulase-negative staphylococi (CoNS) and Candida spp. and clinical significance of this factor. We explaned the characteristics and detection methods of slime factor and several factors affecting the adhesion. Meanwhile, the structure of the biofilm and its influence of the virulence were reassessed comprehensivly. Key words: Coagulase-negative staphylococi, Candida, Slime factor, Biofilm, Adhesion

Keywords

Coagulase-negative staphylococi Candida Slime factor Biofilm Adhesion

References

  • Leonhardt A, Renvert S, Dahlen G. Microbial findings at failing implants. Clin Oral Implants Res. 1999;10:339-45.
  • Baillie GS, Douglas LJ. Effect of growth rate on resistance of Candida albicans biofilms to antifungal agents. Antimicrob Agents Chemother. 1998; 42:1900-5.
  • Bachmann SP, VandeWalle K, Ramage G, Patterson TF, Wickes BL, Graybill JR, Lopez-Ribot JL. In vitro activity of caspofungin against Candida albicans biofilms. Antimicrob Agents Chemother. 2002;46:3591-6.
  • Douglas LJ. Candida biofilms and their role in infection. Trends Microbiol. 2003;11:30-6.
  • Potera C. Forging a link between biofilms and disease. Science. 1999;283:1837-9.
  • Jansen B, Schumacher-Perdreau F, Peters G, Pulverer G. New aspects in the pathogenesis and prevention of polymer-associated foreign-body infections caused by coagulase-negative staphylococci. J Invest Surg. 1989; 2:361-80.
  • Kocazeybek B, Çakan H, Ayyıldız A, Küçükateş E, Gülsoy Ö, Ordu A. Cerrahi yoğun bakım ünitesinden izole edilen koagülaz negatif stafilokoklarda slime faktörü oluşturma ve bunların kemoterapötiklere dirençle ilişkisinin araştırılması. Ankem Derg. 200; 4:683-9.
  • Kalkancı A, Çırak Yalınay M, Mansuroğlu H, Kuştimur S. Candida türlerinde slime faktör belirlenmesi. Türk Mikrobiyol Cem Derg. 1999; 29:183-5.
  • Orhon H, Özbakkaloğlu B, Sürücüoğlu S, Tünger Ö, Arısoy AS. İnfeksiyon etkeni olan Candida albicans suşlarında slime üretimi ve antifungal ajanlara duyarlılıkları. Türk Mikrobiyol Cem Derg. 1998;28:103-6.
  • Karaca N, Koç AN, Karagöz S. Kan ve vajen örneklerinden izole edilen Candida türlerinin slime aktiviteleri. Türk Mikrobiyol Cem Derg. 2001;31:224-6.
  • Cengiz SA. Koagülaz negatif stafilokoklar. Tıp ve Diş Hekimliğinde Genel ve Özel Mikrobiyoloji. Cengiz AT, editör. Ankara: Güneş Kitabevi 2004: 351-60.
  • Kloos WE, Bunnerman TL. Staphylococcus and micrococcus. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, editors. Manual of Clinical Microbiology. 6.th ed. Washington DC: ASM Press 1995: 282-98.
  • Kotilainen P. Association of coagulase-negative staphylococcal slime production and adherence with the development and outcome of adult septicemias. J Clin Microbiol. 1990; 28:2779-85.
  • Christensen GD, Simpson WA, Younger JJ, Baddour LM, Barrett FF, Melton DM, Beachey EH. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol. 1985;22:996-1006.
  • Christensen GD, Simpson WA, Bisno AL, Beachey EH. Adherence of slime- producing strains of Staphylococcus epidermidis to smooth surfaces. Infect Immun. 1982;37:318-26.
  • Christensen GD, Baldassari L, Simpson WA. Colonization of medical devices by coagulase-negative staphylococci. Bisno A, Waldvogel FA, editors. Infections associated with indwelling Medical devices. 2 nd ed. Washington DC: ASM Press 1994: 45-78.
  • Deighton MA, Balkau B. Adherence measured by microtiter assay as a virulence marker for Staphylococcus epidermidis infections. J Clin Microbiol. 1990;28:2442-7.
  • Younger JJ, Christensen GD, Bartley DL, Simmons JC, Barrett FF. Coagulase- negative staphylococci isolated from cerebrospinal fluid shunts: importance of slime production, species identification, and shunt removal to clinical outcome. J Infect Dis. 1987;156:548-54
  • Freeman DJ, Falkiner FR, Keane CT. New method for detecting slime production by coagulase negative staphylococci. J Clin Pathol. 1989;42:872-4.
  • Aydınlı A, Durmaz G, Akgün Y. Koagülaz negatif stafilokoklarda slime faktör yapımının kongo kırmızılı agar yöntemi ile araştırılması. Flora.1997; 1:41-4.
  • Kaleli İ, Demir M. Koagülaz negatif stafilokoklarda slime faktör yapımının iki ayrı yöntem ile ve farklı atmosfer ortamlarında araştırılması. Türkiye Tıp Dergisi. 1999; 6:226-30.
  • Kiraz N. Koagülaz negatif stafilokokların “Slime” oluşturmaları ve bazı antibiyotiklerin “Slime” oluşumuna etkileri. Türk Mikrobiyol Cem Derg. 1993; 23: 219-25.
  • The gram-positive cocci: Part-1: Staphylococci and related organisms. Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Win WC, editors. In: Color Atlas and Textbook of Diagnostic Microbiology. 5 th ed. Philadelphia: JB Lippincott Company 1997: 539-76.
  • Denyer SP, Davies MC, Evans JA, Finch RG, Smith DG, Wilcox MH, Williams P. Influence of carbon dioxide on the surface characteristics and adherence potential of coagulase-negative staphylococci. J Clin Microbiol. 1990;28:1813-7.
  • Barker LP, Simpson WA, Christensen GD. Differential production of slime under aerobic and anaerobic conditions. J Clin Microbiol. 1990; 28:2578-9.
  • Songür M, Sayan M, Yüce A, Yuluğ N. Koagülaz negatif stafilokoklarda slime üretimi ile değişik inkübasyon ortamlarının ilişkisi. İnfeksiyon Dergisi. 1998;12: 29-33.
  • el-Azizi M, Khardori N. Factors influencing adherence of Candida spp. to host tissues and plastic surfaces.Indian J Exp Biol. 1999;37:941-51.
  • Costa Pires MF, Correa B, Gambale W, Rodrigues Paula C. Experimental model of Candida albicans (serotype A and B) adherence in vitro. Brazil J Microbiol. 2001; 32:163-69.
  • Cotter G, Kavanagh K. Adherence mechanisms of Candida albicans. Br J Biomed Sci. 2000;57:241-9.
  • Ollert MW, Sohnchen R, Korting HC, Ollert U, Brautigam S, Brautigam W. Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun. 1993;61:4560-8.
  • Warren WG, Hazen KC. Candida, Cryptococus and other yeasts of medical importance. In: Murray PR, Baron EJ, Pfaller MA, Jorgensen JH, Yolken RH, editors. Manual of Clinical Microbiology. 8th ed.Washington, DC: ASM press 2003: 1693-711.
  • Mac Farlane TW. Ecology and epidemiology of Candida. In: Samanayake LP, Mac Farlane TW, editors. Oral candidiasis. London,United Kingdom: Butterwort and co 1990: 21-46.
  • Odds FC. Ecology of Candida and epidemiology of Candidiasis. In: Candida and Candidiasis: A review and bibliography. 2nd ed. London, United Kingdom: Bailliere Tindall 1988: 68-92.
  • Abu-Elteen KH, Abu-Alteen RM. The prevalence of Candida albicans populations in the mouths of complete denture wearers. New Microbiol. 1998;21:41-8.
  • Ben-Aryeh H, Blumfield E, Szargel R, Laufer D, Berdicevsky I. Oral Candida carriage and blood group antigen secretor status. Mycoses. 1995;38:355-8.
  • Gökdal İ, Kalkancı A, Paçal G, Altuğ Z. Ortodontik braketlerin yüzeyinde Candida kolonizasyonu ve bu Candida albicans suşlarının agız içi epitel hücrelerine adezyonu. Mikrobiyol Bült. 2002;36:65-9.
  • Sundstrom P. Adhesion in Candida spp. Cell Microbiol. 2002; 4: 461-9.
  • Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol. 2001;183:5385-94.
  • Kamagata-Kiyoura Y, Abe S, Yamaguchi H, Nitta T. Detachment activity of human saliva in vitro for Candida albicans cells attached to a plastic plate. J Infect Chemother. 2003;9:215-20.
  • Fukazawa Y, Kagaya K. Molecular bases of adhesion of Candida albicans. J Med Vet Mycol. 1997;35:87-99.
  • Calderone RA, Braun PC. Adherence and receptor relationships of Candida albicans. Microbiol Rev. 1991;55:1-20.
  • Berg JM, Jymoczko JL, Stryer L. Biochemistry: van der Waals Interactions. 5th ed. New York: WH Freeman and Co 2002:10.
  • Berg JM, Jymoczko JL, Stryer L: Biochemistry: Protein folding can be understood in terms of free-energy changes. 5th ed. New York: WH Freeman and Co 2002: 14.
  • Kalkancı A, Kuştimur S. Candida albicans’ın konak hücreye adezyonu ve klinik önemi. İnfek Derg. 2004; 18:373-80.
  • Branchini ML, Pfaller MA, Rhine-Chalberg J, Frempong T, Isenberg HD. Genotypic variation and slime production among blood and catheter isolates of Candida parapsilosis. J Clin Microbiol. 1994;32:452-6.
  • Pfaller M, Davenport D, Bale M, Barrett M, Koontz F, Massanari RM. Development of the quantitative micro-test for slime production by coagulase-negative staphylococci. Eur J Clin Microbiol Infect Dis. 1988;7:30-3.
  • Hilmioğlu S, İlkit M, Çavuşoğlu C, Aydemir Ş, Tümbay E. Candida kökenlerinde Slaym (Slime) üretiminin üç ayrı yöntemle gösterilmesi ve slaym üretiminin kristal viyole reaksiyonu ile ilişkisi. İnfek Derg.1999;13: 183-6.
  • Arslan U, Fındık D. Klinik örneklerden izole edilen Candida albicans türü maya mantarlarında virulans faktörlerinin (proteinaz, slime ve fosfolipaz) in-vitro araştırılması. İnfek Derg. 2003;17:471-81.
  • Kuştimur S. Kandida patojenezinde rol oynayan faktörler. Mikrobiyol Bült. 1994;28:175-81.
  • Samaranayake YH, Wu PC, Samaranayake LP, So M, Yuen KY. Adhesion and colonisation of Candida krusei on host surfaces. J Med Microbiol. 1994;41:250-8.
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There are 72 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

S. Aslıhan Cengiz This is me

Ebru Us This is me

A. Tevfik Cengiz This is me

Publication Date June 1, 2006
Published in Issue Year 2006 Volume: 13 Issue: 3

Cite

APA Cengiz, S. A., Us, E., & Cengiz, A. T. (2006). Slime Faktörünün Klinikteki Yeri Ve Önemi. Journal of Turgut Ozal Medical Center, 13(3), 193-197.
AMA Cengiz SA, Us E, Cengiz AT. Slime Faktörünün Klinikteki Yeri Ve Önemi. J Turgut Ozal Med Cent. June 2006;13(3):193-197.
Chicago Cengiz, S. Aslıhan, Ebru Us, and A. Tevfik Cengiz. “Slime Faktörünün Klinikteki Yeri Ve Önemi”. Journal of Turgut Ozal Medical Center 13, no. 3 (June 2006): 193-97.
EndNote Cengiz SA, Us E, Cengiz AT (June 1, 2006) Slime Faktörünün Klinikteki Yeri Ve Önemi. Journal of Turgut Ozal Medical Center 13 3 193–197.
IEEE S. A. Cengiz, E. Us, and A. T. Cengiz, “Slime Faktörünün Klinikteki Yeri Ve Önemi”, J Turgut Ozal Med Cent, vol. 13, no. 3, pp. 193–197, 2006.
ISNAD Cengiz, S. Aslıhan et al. “Slime Faktörünün Klinikteki Yeri Ve Önemi”. Journal of Turgut Ozal Medical Center 13/3 (June 2006), 193-197.
JAMA Cengiz SA, Us E, Cengiz AT. Slime Faktörünün Klinikteki Yeri Ve Önemi. J Turgut Ozal Med Cent. 2006;13:193–197.
MLA Cengiz, S. Aslıhan et al. “Slime Faktörünün Klinikteki Yeri Ve Önemi”. Journal of Turgut Ozal Medical Center, vol. 13, no. 3, 2006, pp. 193-7.
Vancouver Cengiz SA, Us E, Cengiz AT. Slime Faktörünün Klinikteki Yeri Ve Önemi. J Turgut Ozal Med Cent. 2006;13(3):193-7.