Multiple Sclerosis And Psoriasis

Year 2005, Volume: 12 Issue: 1, - , 01.02.2005

Handan Işın Özışık Sibel Kızkın Ersoy Hazneci Cemal Özcan

Abstract

Natural and recombinant interferons are increasingly being used to treat patients with multiple sclerosis and various inflammatory, infectious, and neoplastic processes. Adverse reactions are usually limited to headache, fever, and myalgia, but occasional unexpected problems can be severe enough to limit use of the drug. One such problem is the exacerbation of psoriasis. In our clinic, two patients with multiple sclerosis who were receiving injections of interferon had a psoriasis attack. One of the patients had psoriasis before the interferon treatment but other patient had no such history. Key words: Multiple Sclerosis, Beta Interferon, Psoriasis.

Keywords

Multiple Sclerosis, Beta Interferon, Psoriasis.

Multiple Skleroz ve Psoriasis

Abstract

Rekombinant interferonlar Multiple Skleroz (MS) yanısıra çeşitli enflamatuar hastalıklarda, Hepatit C gibi enfeksiyonlarda ve lösemi gibi neoplasmlarda artan oranlarda kullanılmaya başlanmıştır. Yan etkileri genellikle; başağrısı, ateş ve myaljidir, ancak ender olarak ilacın kullanımını sınırlayan daha ciddi yan etkiler de bildirilmiştir. MS'lu hastalarda diğer otoimmun hastalıkların insidansı genel populasyondan çok daha yüksek orandadır. MS'da psoriasis birlikteliği az sayıda hastada bildirilmiştir. Kliniğimizde izlenen 2 MS'lu olguda beta-interferon tedavisi ile psoriasis atağı gözlendi. Olgulardan biri daha önce psoriasis tanısı almıştı. Diğer olguda özgeçmişinde psoriasis tanısı yoktu. Her iki olguda da beta interferon tedavisinin 2. haftasında döküntüler oluştu. Literatürde Psorisisin beta interferonla alevlendiğine ait bir bilgiye rastlanmadığı için olgular sunulmaya değer bulundu. Anahtar kelimeler: Multiple skleroz, Beta interferon, Psoriasis

Keywords

Multiple skleroz, Beta interferon, Psoriasis

References

• Webster GF, Knobler RL, Lublin FD et al. Cutaneous ulcerations and pustuler psoriasis flare caused by recombinant interferon beta injections in patients with multiple sclerosis. J Am Acad dermatol 1996;34:365-7.
• Georgetson M.J, Yarze JC, Lalos AT et al. Exacerbation of psoriasis due to interferon alpha treatment of chronic active hepatitis. Am J Gastroenterol 1993;88:1756-8
• Quesada J, Gutterman J. Psoriasis and interferon alpha. Lancet 1986;1:1466-8.
• Duquette P, Girard M, Knobler RL, et al. Interferon beta-1b is effective in relapsing- remitting multiple sclerosis.I.Clinical results of a multicenter, randomized double- blind, placebo-controlled trial. Neurology 1993;43:655-61.
• Paty DW, Li DKB. MS/MRI Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis.II.MRI analysis of a multicenter, randomized double-blind, placebo-controlled trial. Neurology 1993;43:662-67
• Broadley SA, Deans J, Sawcer SJ et al. Autoimmune disease in first-degree relatives of patients with multiple sclerosis. Brain 2000;123:1102-1111.
• Heinzlef O, Alamowitch S, Sazdovitch V et al. . Autoimmune disease in families of French patients with multiple sclerosis. Acta Neurol Scand 2000; 101(1):36-40.
• Midgard R, Gronning M, Riise T et al. Multiple sclerosis and chronic inflammatory diseases. A case-control study. Acta Neurol Scand 1996;93:322-328.
• Schwid SR, Goodman AD, Mattson DH. Autoimmune hyperthyroidism in patients with multiple sclerosis treated with interferon beta-1b. Arch Neurol 1997;57:1169- 1170.