Gastric Hepatoid Adenocarcinoma: A Case Report and Literature Update

Year 2015, Volume: 22 Issue: 3, 210 - 212, 14.12.2015

Şamil Ecirli Yavuz Sultan Selim Akgül Orkide Kutlu , Gökhan Güngör Abdullah Sakin

Abstract

Hepatoid adenocarcinomas (HAC) are very rare extrahepatic tumours that have very poor prognosis. The majority of these tumors are recognized by the height in serum AFP. The incidence rate for reported gastric tumours from the Far East is between 1,3% and 15% but there are only case reports available from other regions. There are two types of HAC: well-differentiated papillary/tubular type and medullary type with polygonal cells. AFP, CEA, CK7, and CK20 have effects on survival. HAC is treated in the way traditional gastric adenocarcinomas are treated. Hepatoid adenocarcinoma of the stomach has poor prognosis. It is often metastatic at diagnosis with an average life expectancy of 4,7 months. Here, we present a rare case of a chemotherapy-resistant patient diagnosed with hepatoid adenocarcinoma in our clinic.

Key Word: Hepatoid Adenocarcinoma; AFP; HCC.

Keywords

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Journal of Turgut Ozal Medical Center

Abstract

Hepatoid adenokarsinomalar (HAC) çok nadir rastlanan ve oldukça kötü prognozlu ekstrahepatik tümörlerdir. Bu tümörlerin büyük çoğunluğu serumda AFP yüksekliği ile tanınmaktadır. İnsidansı en sık görüldüğü Uzakdoğu için gastrik tümörlerin %1,3–15 olarak bildirilmiş, diğer bölgelerden vakalar şeklinde bildirim mevcuttur. İyi differansiye papiller/tubuler ve poligonal hücrelerden oluşan medüller tip olmak üzere iki tipi tanımlanmıştır. AFP, CEA, CK7 ve CK20 nin survi üzerine etkisi gösterilmiştir. HAC lar da klasik mide adenokarsinomaları gibi tedavi edilmeye çalışılır. Adjuvan kemo-radyoterapi verilebilir. Midenin hepatoid adenokanseri kötü prognozludur. Genellikle tanı konduğunda metastatik olup, ortalama yaşam beklentisi 4,7 aydır. Burada kliniğimizde hepatoid adenokarsinoma tanısı koyduğumuz ve kemoterapiye dirençli hastamızı nadir rastlanması sebebi ile sunduk

Keywords

Hepatoid Adenokarsinom, AFP, HCC

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