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Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40

Year 2015, Volume: 22 Issue: 4, 253 - 256, 14.12.2015

Abstract

Aim: The aim of this study is to investigate the association between subfoveal choroidal thickness, ocular axial length, and refractive errors in healthy adults.

Materials and Methods: A hundred eyes of 50 patients were included in this study. A full ophtalmic examination including best corrected visual acuity, refractive levels, and interferometric ocular axial length was applied to all the patients. The submacular choroidal was imaged using enhanced depth imaging spectral domain optical cohorence tomography. Subfoveal choroidal thickness was measured by two diifferent experts using visual inspection and manual fitting of the choroidal borderlines.

Results: Of the 50 subjects, 24 were males and 26 were females. The results of the applied measurements were as follows: mean age: 28,9(±6,8); visual acuity: 0,95±0,16; mean subfoveal choroidal thickness: 302,64µm(±52,07); mean axial lentgh: 23,59mm(±0,94); mean intraoculer pressure 14,5±2,3; and mean spheric equivalent -0,47(±0,97). No significant difference between males and females was observed in terms of mean subfoveal choridal thickness. Multivariable linear regression suggested that age was not associated with subfoveal choroidal thickness (r=-0,247; p=0,106). There was no correlation between axial length and subfoveal choroidal thickness either (r=-0,128; p=0,234). There was, however, a positive correlation between spheric equivalents and subfoveal choroidal thickness (r=0,227; p=0,033).

Conclusion: In this study, we found that subfoveal choroidal thickness was significantly associated with spheric equivalent while there was no association between axial length and subfoveal choroidal thickness. We also observed that there was no difference between males and females with regards to subfoveal choroidal thickness.

Keywords: Choroidal Thickness; Axial Length.

References

  • Nickla DL,WallmanJ.The multifonctional choroid.Prog Retin Eye Res 2010;29:144-68.
  • Levin LA, Nilsson SFE, Ver Hoeve J,Wu S,Kaufman PL,Alm A,eds.Adler’s Physiology of the Eye,11th ed.New York NY:Saunders/Elsevier, 2011.
  • Imamura Y,Fujiwara T,Margolis R,Spaide RF. Enhanced depth imaging optical cohorence tomography of the choroid in central serous chorioretinopathy. Retina 2009;29:1469-73.
  • Chung SE,Kang SW, Lee JH,Kim YT.Choroidal thickness inpolypoidal choridal vasculopathy and exudative age- realeted macular degeneration. Ophthalmology 2011; 118:840-5.
  • Fujiwara T,Imamura Y, Margolis R, Slakter JS, SpaideRF Enhanced depth imaging optical cohorence tomography of the choroid in highyl myopic eyes.Am J Ophthalmol 2009;148:445-50.
  • Nickla DL, Wallman J. The multifonctional choroid. Prog Retin Eye Res 2010;29:144-168.
  • Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral –domain optical cohorence tomography. Am J Ophthalmol 2008;146:496-500.
  • Manjunath V, Taha M, Fujimoto JG, Duker JS. Choroidal thickness in normal eyes measured using Cirrus HD optical cohorence tomography. Am J Ophthalmol 2010;150:325-9.
  • Margolis R, Spaide RF, A pilot study of Enhanced depth imaging optical cohorence tomography of the choroid in normal eyes. Am J ophtalmol 2009;147;811-5.
  • Wallman J,Wildsoet C, Xu A, Gottlieb MD, Nickla DL, Marran L,.Moving the retina: choroidal modülation of refractive state. Vision Res 1995;35:7-50.
  • Ikuno Y, Kawaguchi K, Nouchi T, Yassuno Y. Choroidal thickness in healty japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173-6.
  • Xiao Qiang Lİ, Michael Larsen, Inger Chiristine Munch. Invest Ophthalmol Vis Sci 2011;52:8438-41.
  • Song WK, Lee SC, Lee ES, Kim CY, Kim SS. Macular thickness variations with sex, age and axial length in healty subjects: a spectral –domain optical cohorence tomography study Invest Ophthalmol Vis Sci 2010;51:3913-8.
  • Wagner- Schuman M, Dubis AM, Nordgren RN, et all. Race and sex-realeted differences in retinal thickness and foveal pit morpholmology. Invest Ophthalmol Vis Sci 2011;52:625-34.
  • Wickman LA, GaoJ, Toda I, Rocha EM, Ono M,Sullivan DA.İdentification of androjen,estrojen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 2000;78:146-53.
  • Munaut C, Lambert V,Noel A, et all. Presence of oestrogen receptor type beta in human retina.Br J Ophthalmol 2001;85:877-82.
  • Kavruolaki D, Gugleta K, Kockorow A, Katamay R, Flammer J, Orgul S. Influence of gender and menoposal status on peripheral and choroidal circulation. Acta Ophthalmol 2010;88:850-3.
  • Centofanti M, Bonini S, Manni G, Guıinetti-Neuschuler C,Bucci MG, Harris A, Do sex and hormonal status influence choroidal circulation? Br J Ophthalmol 2000; 84:786-7.
  • Ramrattan RS, van der Schaft TL, Mooy CM, de Brujin WC, Mulder PG, de Jong PT. Morphometric analysis of Bruchs membrane, the choriocapillaris, and choroid in aging. Invest Ophthalmol Vis Sci 1994;35:2857-64.
  • Ding XY, Lİ JQ, Zeng J, Ma W, Liu R, Li T, Yu SS,Tang SB. Choroidal thickness in healty Chinese subjects. Invest Ophthalmol Vis Sci 2011;52:9555-60.
  • Read SA, Collins MJ, Sander BP.Human optical axial length and defocus. Invest Ophthalmol Vis Sci 2010;51:6262-9.
  • Cartwright NEK, Tyrer JR, Marshall J.Age realeted differnces in the elasticity of the human cornea. Invest Ophthalmol Vis Sci 2011;52:4324-9.
  • Min Kim, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee Optom Vis Sci 2014;91:491-6.

Journal of Turgut Ozal Medical Center

Year 2015, Volume: 22 Issue: 4, 253 - 256, 14.12.2015

Abstract

Amaç: 20-40 yaş arası sağlıklı erişkinlerde subfoveal koroidal kalınlık ile aksiyel uzunluk, refraksiyon kusuru arasındaki ilişkiyi incelemek. Gereç ve Yöntemler: Çalışmaya 50 sağlıklı bireyin 100 gözü dahil edildi. Çalışmaya katılan bireylerin en iyi düzeltilmiş görme keskinlikleri, refraksiyon değerleri, göz içi basınçları, interferometrik aksiyal uzunluk ölçümlerini içeren tam oftalmolojik muyaneleri yapıldı. Subfoveal koroidal kalınlık ölçümü; optikal koherens tomografi(OKT) ile koryokapilleris yapısının sınırlarının görsel ve işaretleme yöntemi kullanılarak iki ayrı kişi tarafından yapıldı. Bulgular: Çalışmaya dahil edilen bireylerin 24’ükadın, 26’sı erkek ve ortalama yaşı28,9(±6,8)’idi. Görme keskinlikleri 0,95±0,16; ortalama subfoveal koroidal kalınlık 302,64μm(±52,07); ortalama aksiyel uzunluk 23,59mm(±0,94); göz içi basınçları14,5±2,3; ortalama sferik ekivalanı -0,47(±0,97)’ idi. Erkek bireylerde ortalama subfoveal koroidal kalınlık 306,25μm(±61,9), kadınlarda 306,13μm(±58,9)Ortalama yaş ile subfoveal koroidal kalınlık arasında anlamlı bir ilişkiye rastlanılmadı.(r=-0,247, p=0,106) Subfoveal koroidal kalınlık ile aksiyel uzunluk arasında anlamlı bir ilişki yok iken (r=-0,128, p=0,234 ) subfoveal koroidal kalınlık ile sferik ekivalan arasında pozitif yönde anlamlı bir ilişki vardı.(r=0,227, p=0,033) Sonuç: Bu çalışmada genç sağlıklı erişkinlerde ortalama subfoveal koroidal kalınlığın erkek ve kadın bireyler arasında farklı olmadığı görüldü. Subfoveal koroidal kalınlık ile aksiyel uzunluk arasında anlamlı bir ilişki bulunmazken, sferik ekivalan arasında pozitif yönde ilişki mevcuttu

References

  • Nickla DL,WallmanJ.The multifonctional choroid.Prog Retin Eye Res 2010;29:144-68.
  • Levin LA, Nilsson SFE, Ver Hoeve J,Wu S,Kaufman PL,Alm A,eds.Adler’s Physiology of the Eye,11th ed.New York NY:Saunders/Elsevier, 2011.
  • Imamura Y,Fujiwara T,Margolis R,Spaide RF. Enhanced depth imaging optical cohorence tomography of the choroid in central serous chorioretinopathy. Retina 2009;29:1469-73.
  • Chung SE,Kang SW, Lee JH,Kim YT.Choroidal thickness inpolypoidal choridal vasculopathy and exudative age- realeted macular degeneration. Ophthalmology 2011; 118:840-5.
  • Fujiwara T,Imamura Y, Margolis R, Slakter JS, SpaideRF Enhanced depth imaging optical cohorence tomography of the choroid in highyl myopic eyes.Am J Ophthalmol 2009;148:445-50.
  • Nickla DL, Wallman J. The multifonctional choroid. Prog Retin Eye Res 2010;29:144-168.
  • Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral –domain optical cohorence tomography. Am J Ophthalmol 2008;146:496-500.
  • Manjunath V, Taha M, Fujimoto JG, Duker JS. Choroidal thickness in normal eyes measured using Cirrus HD optical cohorence tomography. Am J Ophthalmol 2010;150:325-9.
  • Margolis R, Spaide RF, A pilot study of Enhanced depth imaging optical cohorence tomography of the choroid in normal eyes. Am J ophtalmol 2009;147;811-5.
  • Wallman J,Wildsoet C, Xu A, Gottlieb MD, Nickla DL, Marran L,.Moving the retina: choroidal modülation of refractive state. Vision Res 1995;35:7-50.
  • Ikuno Y, Kawaguchi K, Nouchi T, Yassuno Y. Choroidal thickness in healty japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173-6.
  • Xiao Qiang Lİ, Michael Larsen, Inger Chiristine Munch. Invest Ophthalmol Vis Sci 2011;52:8438-41.
  • Song WK, Lee SC, Lee ES, Kim CY, Kim SS. Macular thickness variations with sex, age and axial length in healty subjects: a spectral –domain optical cohorence tomography study Invest Ophthalmol Vis Sci 2010;51:3913-8.
  • Wagner- Schuman M, Dubis AM, Nordgren RN, et all. Race and sex-realeted differences in retinal thickness and foveal pit morpholmology. Invest Ophthalmol Vis Sci 2011;52:625-34.
  • Wickman LA, GaoJ, Toda I, Rocha EM, Ono M,Sullivan DA.İdentification of androjen,estrojen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 2000;78:146-53.
  • Munaut C, Lambert V,Noel A, et all. Presence of oestrogen receptor type beta in human retina.Br J Ophthalmol 2001;85:877-82.
  • Kavruolaki D, Gugleta K, Kockorow A, Katamay R, Flammer J, Orgul S. Influence of gender and menoposal status on peripheral and choroidal circulation. Acta Ophthalmol 2010;88:850-3.
  • Centofanti M, Bonini S, Manni G, Guıinetti-Neuschuler C,Bucci MG, Harris A, Do sex and hormonal status influence choroidal circulation? Br J Ophthalmol 2000; 84:786-7.
  • Ramrattan RS, van der Schaft TL, Mooy CM, de Brujin WC, Mulder PG, de Jong PT. Morphometric analysis of Bruchs membrane, the choriocapillaris, and choroid in aging. Invest Ophthalmol Vis Sci 1994;35:2857-64.
  • Ding XY, Lİ JQ, Zeng J, Ma W, Liu R, Li T, Yu SS,Tang SB. Choroidal thickness in healty Chinese subjects. Invest Ophthalmol Vis Sci 2011;52:9555-60.
  • Read SA, Collins MJ, Sander BP.Human optical axial length and defocus. Invest Ophthalmol Vis Sci 2010;51:6262-9.
  • Cartwright NEK, Tyrer JR, Marshall J.Age realeted differnces in the elasticity of the human cornea. Invest Ophthalmol Vis Sci 2011;52:4324-9.
  • Min Kim, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee Optom Vis Sci 2014;91:491-6.
There are 23 citations in total.

Details

Primary Language Tr
Journal Section Articles
Authors

Mehmet Ragıp Ekmen This is me

Publication Date December 14, 2015
Published in Issue Year 2015 Volume: 22 Issue: 4

Cite

APA Ekmen, M. R. (2015). Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40. Journal of Turgut Ozal Medical Center, 22(4), 253-256.
AMA Ekmen MR. Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40. J Turgut Ozal Med Cent. December 2015;22(4):253-256.
Chicago Ekmen, Mehmet Ragıp. “Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40”. Journal of Turgut Ozal Medical Center 22, no. 4 (December 2015): 253-56.
EndNote Ekmen MR (December 1, 2015) Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40. Journal of Turgut Ozal Medical Center 22 4 253–256.
IEEE M. R. Ekmen, “Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40”, J Turgut Ozal Med Cent, vol. 22, no. 4, pp. 253–256, 2015.
ISNAD Ekmen, Mehmet Ragıp. “Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40”. Journal of Turgut Ozal Medical Center 22/4 (December 2015), 253-256.
JAMA Ekmen MR. Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40. J Turgut Ozal Med Cent. 2015;22:253–256.
MLA Ekmen, Mehmet Ragıp. “Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40”. Journal of Turgut Ozal Medical Center, vol. 22, no. 4, 2015, pp. 253-6.
Vancouver Ekmen MR. Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40. J Turgut Ozal Med Cent. 2015;22(4):253-6.