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The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas

Year 2015, Volume: 22 Issue: 4, 257 - 260, 15.12.2015

Ebru Ünlü Sena Ulu Şerife Özdinç Elif Dogan Baki Emre Kaçar Mehtap Beker Acay Ergün Karavelioğlu Emel Yılmaz Hanife Uzel Tas

Abstract

Objective: The linear relationship between density of hematomas on unenhanced computed tomography and hemoglobin levels were shown before. However, there are no studies about the effects of platelet count and functions on density values of hematomas. Our aim is to investigate the relationship between the density of hematomas measured on unenhanced Computed Tomography scans and platelet count and functions.

Materials and Methods: Seventy seven patients diagnosed with intracranial hematoma by unenhanced computed tomography scans between the ages of 10 and 89, who did not have anemia or coagulopathy, were included in the study. The density values of intracranial hematomas were measured on independent computed tomography diagnostic console. Patients were divided into two groups according to their hematoma densities as higher or lower than 60 Hounsfield Units. The relationship between the densities of hematomas and platelet count, mean platelet volume, platelet distribution width, hemoglobin, hematocrit, and red cell distribution width were investigated in all the patient population among the two groups.

Results: It has been found that the hematoma densities were only significantly correlated with mean platelet volume values among the blood parameters in the study population (p=0,007). Also, a significantly statistical correlation was found between mean platelet volume values of the two groups. (p=0,003).

Conclusion: Mean platelet volume is a significant factor that affects hematoma density value on computed tomography like hemoglobin. It is considered that this finding may also be a reason that explains the differences between hematoma densities of patients without anemia and coagulopathy.

Keywords: Intracranial Hematoma; Computed Tomography; Mean Platelet Volume.

Keywords

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References

  • Broderick JP, Adams HP Jr, Barsan W, Feinberg W, Feldmann E, Grotta J, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council. Stroke 1999;30:905-15.
  • Opeskin K, Silberstein M. False positive diagnosis of subarachnoid haemorrhage on computed tomography scan. J Clin Neurosci 1998;5:382-6.
  • Smith WP Jr, Batnitzky S, Rengachary SS. Acute isodense subdural hematomas: a problem in anemic patients. AJR Am J Roentgenol 1981;136:543-6.
  • New PF, Aronow S. Attenuation measurements of whole blood and blood fractions in computed tomography. Radiology 1976;121:635-40.
  • Boyko OB, Cooper DF, Grossman CB. Contrast-enhanced CT of acute isodense subdural hematoma. AJNR Am J Neuroradiol 1991;12:341-3.
  • Parizel PM, Makkat S, Van Miert E, Van Goethem JW, van den Hauwe L, De Schepper AM. Intracranial hemorrhage: principles of CT and MRI interpretation. Eur Radiol 2001;11:1770-83.
  • Ziai WC, Torbey MT, Kickler TS, Oh S, Bhardwaj A, Wityk RJ. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2003;12:201-6.
  • Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
  • Martin JF, Shaw T, Heggie J, Penington DG. Measurement of the density of platelets and its relationship to volume. Br J Haematol 1983;54:337–52.
  • Nakada T, Kwee IL. Computed tomography-negative acute thalamic hematoma. J Neuroimaging 1996;6:119-21.
  • Sandercock P, Foy PM, Brock LG. Negative computerised tomographic scan in patient with intracerebral haematoma. Lancet 1986;1:1506-7.
  • Packard AS, Kase CS, Aly AS, Barest GD. "Computed tomography-negative" intracerebral hemorrhage: case report and implications for management. Arch Neurol 2003;60:1156-9.
  • Ito H, Maeda M, Uehara T, Yamamoto S, Tamura M, Takashima T. Attenuation values of chronic subdural haematoma and subdural effusion in CT scans. Acta Neurochir (Wien) 1984;72:211–7.
  • Ben Salem D, Osseby GV, Rezaizadeh-Bourdariat K, Pastural G, Martin D, Brunotte F, et al. Spontaneous hyperdense intracranial vessels seen on CT scan in polycythemia cases. J Radiol 2003;84:605-8.
  • Kamath S, Blann AD, Lip GY. Platelet activation: Assesment and quantification. Eur Heart J 2001;22:1561-71.
  • Jagroop IA, Tsiara S, Mikhailidis DP. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets 2003;14:335-6.

Journal of Turgut Ozal Medical Center

Year 2015, Volume: 22 Issue: 4, 257 - 260, 15.12.2015

Ebru Ünlü Sena Ulu Şerife Özdinç Elif Dogan Baki Emre Kaçar Mehtap Beker Acay Ergün Karavelioğlu Emel Yılmaz Hanife Uzel Tas

Abstract

Amaç: İntrakranial hematomların kontrastsız bilgisayarlı tomografi dansite değerleri ile hemoglobin seviyeleri arasındaki lineer ilişki daha önceden gösterilmiştir. Ancak, trombosit sayı ve fonksiyonlarının, hematomların dansite değerlerine olan etkisi ile ilgili yapılmış bir çalışma henüz yoktur. Amacımız kontrastsız bilgisayarlı tomografi görüntülerinde ölçülen hematom dansite değerlerinin, trombosit sayı ve fonksiyonları ile ilişkisini araştırmaktır. Gereç ve Yöntemler: Çalışmaya, ilk 12 saat içerisinde kontrastsız bilgisayarlı tomografi tetkiki ile intrakranial hematom tanısı konulan, anemisi ve koagulopatisi olmayan, 10 ile 89 yaşları arasında 77 hasta dahil edildi. Bilgisayarlı tomografi bağımsız tanı konsolunda, intrakranial hematomların dansite değerleri ölçüldü. Hastalar hematom dansite değerlerine göre, dansitesi 60 Hounsfield birimin altında olanlar ve üstünde olanlar olmak üzere iki gruba ayrıldı. İntrakranial hematomların dansite değerleri ile trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği, hemoglobin, hemotokrit, eritrosit dağılım genişliği değerleri arasındaki ilişki tüm hasta populasyonunda ve iki grup arasında karşılaştırılarak değerlendirildi. Bulgular: Tüm çalışma populasyonunda hematom dansiteleri ile tam kan parametreleri arasında sadece ortalama trombosit hacmi değerleri ile anlamlı korelasyon bulundu (p=0,007). Ayrıca iki grupta ortalama trombosit hacimleri arasında istatistiksel olarak anlamlı farklılık saptandı (p=0,003). Sonuç: Ortalama trombosit hacmi, hematomların bilgisayarlı tomografi dansite değerlerini hemoglobin değerleri gibi etkileyen önemli bir faktördür. Bu bulgunun anemisi ve koagulopatisi olmayan hastalarda izlenen hematom dansite farklılıklarını da açıklayan bir neden olabileceği düşünülmüştür

Keywords

İntrakranial Hematom Bilgisayarlı Tomografi Ortalama Trombosit Hacmi

References

  • Broderick JP, Adams HP Jr, Barsan W, Feinberg W, Feldmann E, Grotta J, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council. Stroke 1999;30:905-15.
  • Opeskin K, Silberstein M. False positive diagnosis of subarachnoid haemorrhage on computed tomography scan. J Clin Neurosci 1998;5:382-6.
  • Smith WP Jr, Batnitzky S, Rengachary SS. Acute isodense subdural hematomas: a problem in anemic patients. AJR Am J Roentgenol 1981;136:543-6.
  • New PF, Aronow S. Attenuation measurements of whole blood and blood fractions in computed tomography. Radiology 1976;121:635-40.
  • Boyko OB, Cooper DF, Grossman CB. Contrast-enhanced CT of acute isodense subdural hematoma. AJNR Am J Neuroradiol 1991;12:341-3.
  • Parizel PM, Makkat S, Van Miert E, Van Goethem JW, van den Hauwe L, De Schepper AM. Intracranial hemorrhage: principles of CT and MRI interpretation. Eur Radiol 2001;11:1770-83.
  • Ziai WC, Torbey MT, Kickler TS, Oh S, Bhardwaj A, Wityk RJ. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2003;12:201-6.
  • Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
  • Martin JF, Shaw T, Heggie J, Penington DG. Measurement of the density of platelets and its relationship to volume. Br J Haematol 1983;54:337–52.
  • Nakada T, Kwee IL. Computed tomography-negative acute thalamic hematoma. J Neuroimaging 1996;6:119-21.
  • Sandercock P, Foy PM, Brock LG. Negative computerised tomographic scan in patient with intracerebral haematoma. Lancet 1986;1:1506-7.
  • Packard AS, Kase CS, Aly AS, Barest GD. "Computed tomography-negative" intracerebral hemorrhage: case report and implications for management. Arch Neurol 2003;60:1156-9.
  • Ito H, Maeda M, Uehara T, Yamamoto S, Tamura M, Takashima T. Attenuation values of chronic subdural haematoma and subdural effusion in CT scans. Acta Neurochir (Wien) 1984;72:211–7.
  • Ben Salem D, Osseby GV, Rezaizadeh-Bourdariat K, Pastural G, Martin D, Brunotte F, et al. Spontaneous hyperdense intracranial vessels seen on CT scan in polycythemia cases. J Radiol 2003;84:605-8.
  • Kamath S, Blann AD, Lip GY. Platelet activation: Assesment and quantification. Eur Heart J 2001;22:1561-71.
  • Jagroop IA, Tsiara S, Mikhailidis DP. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets 2003;14:335-6.
There are 16 citations in total.

Details

Primary Language Tr
Journal Section Articles
Authors

Ebru Ünlü This is me

Sena Ulu This is me

Şerife Özdinç This is me

Elif Dogan Baki This is me

Emre Kaçar This is me

Mehtap Beker Acay This is me

Ergün Karavelioğlu This is me

Emel Yılmaz This is me

Hanife Uzel Tas This is me

Publication Date December 15, 2015
Published in Issue Year 2015 Volume: 22 Issue: 4

Cite

APA Ünlü, E., Ulu, S., Özdinç, Ş., Baki, E. D., et al. (2015). The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas. Journal of Turgut Ozal Medical Center, 22(4), 257-260.
AMA Ünlü E, Ulu S, Özdinç Ş, Baki ED, Kaçar E, Beker Acay M, Karavelioğlu E, Yılmaz E, Uzel Tas H. The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas. J Turgut Ozal Med Cent. December 2015;22(4):257-260.
Chicago Ünlü, Ebru, Sena Ulu, Şerife Özdinç, Elif Dogan Baki, Emre Kaçar, Mehtap Beker Acay, Ergün Karavelioğlu, Emel Yılmaz, and Hanife Uzel Tas. “The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas”. Journal of Turgut Ozal Medical Center 22, no. 4 (December 2015): 257-60.
EndNote Ünlü E, Ulu S, Özdinç Ş, Baki ED, Kaçar E, Beker Acay M, Karavelioğlu E, Yılmaz E, Uzel Tas H (December 1, 2015) The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas. Journal of Turgut Ozal Medical Center 22 4 257–260.
IEEE E. Ünlü, S. Ulu, Ş. Özdinç, E. D. Baki, E. Kaçar, M. Beker Acay, E. Karavelioğlu, E. Yılmaz, and H. Uzel Tas, “The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas”, J Turgut Ozal Med Cent, vol. 22, no. 4, pp. 257–260, 2015.
ISNAD Ünlü, Ebru et al. “The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas”. Journal of Turgut Ozal Medical Center 22/4 (December 2015), 257-260.
JAMA Ünlü E, Ulu S, Özdinç Ş, Baki ED, Kaçar E, Beker Acay M, Karavelioğlu E, Yılmaz E, Uzel Tas H. The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas. J Turgut Ozal Med Cent. 2015;22:257–260.
MLA Ünlü, Ebru et al. “The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas”. Journal of Turgut Ozal Medical Center, vol. 22, no. 4, 2015, pp. 257-60.
Vancouver Ünlü E, Ulu S, Özdinç Ş, Baki ED, Kaçar E, Beker Acay M, Karavelioğlu E, Yılmaz E, Uzel Tas H. The Relationship Between Computed Tomography Density Values and Platelet Number and Function in Acute Intracerebral Hematomas. J Turgut Ozal Med Cent. 2015;22(4):257-60.
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