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Cutaneous drug eruptions in children; single centre experience

Year 2011, Volume: 46 Issue: 1, 3 - 7, 01.03.2011
https://doi.org/10.4274/tpa.46.11

Abstract

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References

  • Segal AR, Doherty KM, Leggott J, Ziotoff B. Cutaneous reactions to drugs in children. Pediatrics 2007; 120: 1082-96. (Abstract) / (Full Text) / (PDF)
  • Romano A. Recognising antibacterial hypersensitivity in children. Paediatr Drugs 2000; 2: 101-12. (Abstract) / (Full Text) / (PDF)
  • Mortureux P, Léauté-Labrèze C, Legrain-Lifermann V, Lamireau T, Sarlangue J, Taïeb A. Acute urticaria in infancy and early childhood: a prospective study. Arch Dermatol 1998; 134: 319-23. (Abstract) / (Full Text) / (PDF)
  • Gruchalla R. Understanding drug allergies. J Allergy Clin Immunol 2000; 105: 637-44. (Abstract)
  • Khoo BP, Giam YC. Drug eruptions in children: a review of 111 cases seen in a tertiary skin referral centre. Singapore Med J 2000; 41: 525-9. (Abstract) / (PDF)
  • Weiss J, Krebs S, Hoffmann C, et al. Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection. Pediatrics 2002; 110: 254-7. (Abstract) / (Full Text) / (PDF)
  • Rebelo Gomes E, Fonseca J, Demoly P. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy 2008; 38: 191-8. (Abstract) / (PDF)
  • Söğüt A, Yılmaz Ö, Yıldırım Ş, Özen S, Temiz P, Yüksel H. Amoksisilin-klavulanata bağlı akut yaygın ekzantematöz püstüloz - olgu sunumu Turk Ped Ars 2010; 45: 150-2. (Abstract) / (Full Text) / (PDF)
  • Sacerdoti G, Vozza A, Ruocco V. Identifying skin reactions to drugs. Int J Dermatol 1993; 32: 469-79. (Abstract)
  • Alanko K, Stubb S, Kauppinen K. Cutaneous drug reactions: clinical types and causative agents. Acta Derm Venereol 1989; 69: 223-6. (Abstract)
  • Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272-85. (Abstract) / (Full Text)
  • Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M. Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies. Br J Clin Pharmacol 2001; 52: 77-83. (Abstract) / (PDF)
  • Temple ME, Robinson RF, Miller JC, Hayes JR, Nahata MC. Frequency and preventability of adverse drug reactions in paediatric patients. Drug Saf 2004; 27: 819-29. (Abstract)
  • Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005; 5: 309-16. (Abstract)
  • Demoly P, Viola M, Gomes ER, Romano A. Epidemiology and causes of drug hypersensitivity. In: Pichler WJ (ed). Drug Hypersensitivity. Basel: Karger, 2007: 2-17. (PDF)
  • Sharma VK, Dhar S. Clinical pattern of cutaneous drug eruption among children and adolescents in North India. Pediatr Dermatol 1995; 12: 178-83. (Abstract)
  • Barranco P, Lopez-Serrano MC. General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy 1998; 28: 61-2. (Abstract)
  • Atik F, Aslan Z, Zorlu P. Üst solunum yolu enfeksiyonlarında eğitimin rasyonel klinik yaklaşım ve akılcı antibiyotik kullanımına etkisi. Yeni Tıp Dergisi 2002; 19: 266-9.
  • Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15 438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256: 3358-63. (Abstract)
  • De Weck Al. Pharmacologic and immunochemical mecha- nisms of drug hypersensitivity. Immunol Allergy Clin North Am 1991; 11: 461-74.
  • Cetinkaya F, Cag Y. Penicillin sensitivity among children without a positive history for penicillin allergy. Pediatr Allergy Immunol 2004; 15: 278-80. (Abstract) / (PDF)
  • Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139: 683-93. (Abstract) / (Full Text) / (PDF)
  • Padial A, Antunez C, Blanca-Lopez N, et al. Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy 2008; 38: 822-8. (Abstract) / (PDF)
  • Kulthanan K, Cheepsomsong M, Jiamton S. Urticarial vasculitis: etiologies and clinical course. Asian Pac J Allergy Immunol 2009; 27: 95-102. (Abstract)
  • Mahboob A, Haroon TS. Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol 1998; 37: 833-8. (Abstract)
  • Mockenhaupt M, Viboud C, Dunant A, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 2008; 128: 35-44. (Abstract) / (Full Text) / (PDF)
  • Knowles SR, Shapiro LE, Shear NH. Hypersensitivity reactions to drugs. In: Harper J, Oranje A, Prose N, (eds). Textbook of Pediatric Dermatology. 2nd ed. Oxford: Blackwell, 2006: 2131-41.
  • Kushwaha KP, Verma RB, Singh YD, Rathi AK. Surveillance of drug induced diseases in children. Indian J Pediatr 1994; 61: 357-65. (Abstract)
  • Puavilai S, Noppakun N, Sitakalin C, et al. Drug eruptions at five institutes in Bangkok. J Med Assos Thai 2005; 88: 1642-9. (Abstract)
  • Adkinson NF Jr. Risk factors for drug allergy. J Allergy Clin Immunol 1984; 74: 567-72. (Abstract)

Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi

Year 2011, Volume: 46 Issue: 1, 3 - 7, 01.03.2011
https://doi.org/10.4274/tpa.46.11

Abstract

Amaç: Çocuklarda ilaç iliflkili döküntülerin klinik özellikleri, tipleri, en s›k neden olan ilaçlar ve tan›sal yöntemleri incelemek amaçlanm›flt›r.

Gereç ve Yöntem: ‹leriye dönük çal›flmam›zda, May›s 2006 - May›s 2007’de Dr. Sami Ulus Kad›n Do¤um ve Çocuk Sa¤l›¤› ve Hastal›klar› E¤itim ve Araflt›rma Hastanesi Çocuk Alerji Klini¤i’ne ilaç iliflkili döküntü flüphesiyle baflvuran olgular de¤erlendirildi. Çal›flma hastanemiz Etik Kurulu taraf›ndan onayland›. ‹statistiksel analizler SPSS 11.5 paket program› kullan›larak yap›ld›.

Bulgular: Yüz çocuk çal›flmaya al›nd›. Yafllar› 6 ay ile 14 yafl aras›nda (ortalama 5,6±3,6 y›l) 75 erkek ve 25 k›z çocuk vard›. En s›k ilaç kullan›m gerekçeleri üst solunum yolu enfeksiyonlar› (%64) idi. En yayg›n flüphelenilen ilaçlar olgular›n %44’ünde amoksisilin/ampisilin ve %27’sinde sefalosporinlerdi. ‹laç döküntülerinin tipleri %64’ünde ürtiker, %28’inde makülopapüBulgularntü, %5’inde ürtiker-purpura, %1’inde eritema mültiforme, %1’inde “fiks” ilaç döküntüsü ve %1’inde ise ilaç iliflkili afl›r› duyarl›l›k sendromu idi. Hastalar›n %60’› ‘muhtemel’ ve %16’s› olas› ilaç alerjisi tan›s› al›rken, yaln›zca %18’inde ilaç alerjisi do¤ruland›.

Çıkarımlar: Ayr›nt›l› ilaç öyküsü, ilaç döküntülerinin tiplerinin bilinmesi ve uygun testler; ilaç döküntüsü olan bir çocu¤un baflar›l› yönetimi için gerekli etkenlerdir.

References

  • Segal AR, Doherty KM, Leggott J, Ziotoff B. Cutaneous reactions to drugs in children. Pediatrics 2007; 120: 1082-96. (Abstract) / (Full Text) / (PDF)
  • Romano A. Recognising antibacterial hypersensitivity in children. Paediatr Drugs 2000; 2: 101-12. (Abstract) / (Full Text) / (PDF)
  • Mortureux P, Léauté-Labrèze C, Legrain-Lifermann V, Lamireau T, Sarlangue J, Taïeb A. Acute urticaria in infancy and early childhood: a prospective study. Arch Dermatol 1998; 134: 319-23. (Abstract) / (Full Text) / (PDF)
  • Gruchalla R. Understanding drug allergies. J Allergy Clin Immunol 2000; 105: 637-44. (Abstract)
  • Khoo BP, Giam YC. Drug eruptions in children: a review of 111 cases seen in a tertiary skin referral centre. Singapore Med J 2000; 41: 525-9. (Abstract) / (PDF)
  • Weiss J, Krebs S, Hoffmann C, et al. Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection. Pediatrics 2002; 110: 254-7. (Abstract) / (Full Text) / (PDF)
  • Rebelo Gomes E, Fonseca J, Demoly P. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy 2008; 38: 191-8. (Abstract) / (PDF)
  • Söğüt A, Yılmaz Ö, Yıldırım Ş, Özen S, Temiz P, Yüksel H. Amoksisilin-klavulanata bağlı akut yaygın ekzantematöz püstüloz - olgu sunumu Turk Ped Ars 2010; 45: 150-2. (Abstract) / (Full Text) / (PDF)
  • Sacerdoti G, Vozza A, Ruocco V. Identifying skin reactions to drugs. Int J Dermatol 1993; 32: 469-79. (Abstract)
  • Alanko K, Stubb S, Kauppinen K. Cutaneous drug reactions: clinical types and causative agents. Acta Derm Venereol 1989; 69: 223-6. (Abstract)
  • Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272-85. (Abstract) / (Full Text)
  • Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M. Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies. Br J Clin Pharmacol 2001; 52: 77-83. (Abstract) / (PDF)
  • Temple ME, Robinson RF, Miller JC, Hayes JR, Nahata MC. Frequency and preventability of adverse drug reactions in paediatric patients. Drug Saf 2004; 27: 819-29. (Abstract)
  • Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005; 5: 309-16. (Abstract)
  • Demoly P, Viola M, Gomes ER, Romano A. Epidemiology and causes of drug hypersensitivity. In: Pichler WJ (ed). Drug Hypersensitivity. Basel: Karger, 2007: 2-17. (PDF)
  • Sharma VK, Dhar S. Clinical pattern of cutaneous drug eruption among children and adolescents in North India. Pediatr Dermatol 1995; 12: 178-83. (Abstract)
  • Barranco P, Lopez-Serrano MC. General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy 1998; 28: 61-2. (Abstract)
  • Atik F, Aslan Z, Zorlu P. Üst solunum yolu enfeksiyonlarında eğitimin rasyonel klinik yaklaşım ve akılcı antibiyotik kullanımına etkisi. Yeni Tıp Dergisi 2002; 19: 266-9.
  • Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15 438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256: 3358-63. (Abstract)
  • De Weck Al. Pharmacologic and immunochemical mecha- nisms of drug hypersensitivity. Immunol Allergy Clin North Am 1991; 11: 461-74.
  • Cetinkaya F, Cag Y. Penicillin sensitivity among children without a positive history for penicillin allergy. Pediatr Allergy Immunol 2004; 15: 278-80. (Abstract) / (PDF)
  • Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139: 683-93. (Abstract) / (Full Text) / (PDF)
  • Padial A, Antunez C, Blanca-Lopez N, et al. Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy 2008; 38: 822-8. (Abstract) / (PDF)
  • Kulthanan K, Cheepsomsong M, Jiamton S. Urticarial vasculitis: etiologies and clinical course. Asian Pac J Allergy Immunol 2009; 27: 95-102. (Abstract)
  • Mahboob A, Haroon TS. Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol 1998; 37: 833-8. (Abstract)
  • Mockenhaupt M, Viboud C, Dunant A, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 2008; 128: 35-44. (Abstract) / (Full Text) / (PDF)
  • Knowles SR, Shapiro LE, Shear NH. Hypersensitivity reactions to drugs. In: Harper J, Oranje A, Prose N, (eds). Textbook of Pediatric Dermatology. 2nd ed. Oxford: Blackwell, 2006: 2131-41.
  • Kushwaha KP, Verma RB, Singh YD, Rathi AK. Surveillance of drug induced diseases in children. Indian J Pediatr 1994; 61: 357-65. (Abstract)
  • Puavilai S, Noppakun N, Sitakalin C, et al. Drug eruptions at five institutes in Bangkok. J Med Assos Thai 2005; 88: 1642-9. (Abstract)
  • Adkinson NF Jr. Risk factors for drug allergy. J Allergy Clin Immunol 1984; 74: 567-72. (Abstract)
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Research
Authors

Serap Özmen This is me

Murat Şahin This is me

Aysel Yöney This is me

Nilüfer Arda This is me

Zafer Arslan This is me

Publication Date March 1, 2011
Published in Issue Year 2011 Volume: 46 Issue: 1

Cite

APA Özmen, S., Şahin, M., Yöney, A., Arda, N., et al. (2011). Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi. Türk Pediatri Arşivi, 46(1), 3-7. https://doi.org/10.4274/tpa.46.11
AMA Özmen S, Şahin M, Yöney A, Arda N, Arslan Z. Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi. Türk Pediatri Arşivi. March 2011;46(1):3-7. doi:10.4274/tpa.46.11
Chicago Özmen, Serap, Murat Şahin, Aysel Yöney, Nilüfer Arda, and Zafer Arslan. “Çocuklarda Ilaç ilişkili döküntüler; Tek Merkez Deneyimi”. Türk Pediatri Arşivi 46, no. 1 (March 2011): 3-7. https://doi.org/10.4274/tpa.46.11.
EndNote Özmen S, Şahin M, Yöney A, Arda N, Arslan Z (March 1, 2011) Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi. Türk Pediatri Arşivi 46 1 3–7.
IEEE S. Özmen, M. Şahin, A. Yöney, N. Arda, and Z. Arslan, “Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi”, Türk Pediatri Arşivi, vol. 46, no. 1, pp. 3–7, 2011, doi: 10.4274/tpa.46.11.
ISNAD Özmen, Serap et al. “Çocuklarda Ilaç ilişkili döküntüler; Tek Merkez Deneyimi”. Türk Pediatri Arşivi 46/1 (March 2011), 3-7. https://doi.org/10.4274/tpa.46.11.
JAMA Özmen S, Şahin M, Yöney A, Arda N, Arslan Z. Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi. Türk Pediatri Arşivi. 2011;46:3–7.
MLA Özmen, Serap et al. “Çocuklarda Ilaç ilişkili döküntüler; Tek Merkez Deneyimi”. Türk Pediatri Arşivi, vol. 46, no. 1, 2011, pp. 3-7, doi:10.4274/tpa.46.11.
Vancouver Özmen S, Şahin M, Yöney A, Arda N, Arslan Z. Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi. Türk Pediatri Arşivi. 2011;46(1):3-7.