Cutaneous drug eruptions in children; single centre experience

Yıl 2011, Cilt: 46 Sayı: 1, 3 - 7, 01.03.2011

Serap Özmen Murat Şahin Aysel Yöney Nilüfer Arda Zafer Arslan

https://doi.org/10.4274/tpa.46.11

Öz

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Anahtar Kelimeler

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Çocuklarda ilaç ilişkili döküntüler; tek merkez deneyimi

Öz

Amaç: Çocuklarda ilaç iliflkili döküntülerin klinik özellikleri, tipleri, en s›k neden olan ilaçlar ve tan›sal yöntemleri incelemek amaçlanm›flt›r.

Gereç ve Yöntem: ‹leriye dönük çal›flmam›zda, May›s 2006 - May›s 2007’de Dr. Sami Ulus Kad›n Do¤um ve Çocuk Sa¤l›¤› ve Hastal›klar› E¤itim ve Araflt›rma Hastanesi Çocuk Alerji Klini¤i’ne ilaç iliflkili döküntü flüphesiyle baflvuran olgular de¤erlendirildi. Çal›flma hastanemiz Etik Kurulu taraf›ndan onayland›. ‹statistiksel analizler SPSS 11.5 paket program› kullan›larak yap›ld›.

Bulgular: Yüz çocuk çal›flmaya al›nd›. Yafllar› 6 ay ile 14 yafl aras›nda (ortalama 5,6±3,6 y›l) 75 erkek ve 25 k›z çocuk vard›. En s›k ilaç kullan›m gerekçeleri üst solunum yolu enfeksiyonlar› (%64) idi. En yayg›n flüphelenilen ilaçlar olgular›n %44’ünde amoksisilin/ampisilin ve %27’sinde sefalosporinlerdi. ‹laç döküntülerinin tipleri %64’ünde ürtiker, %28’inde makülopapüBulgularntü, %5’inde ürtiker-purpura, %1’inde eritema mültiforme, %1’inde “fiks” ilaç döküntüsü ve %1’inde ise ilaç iliflkili afl›r› duyarl›l›k sendromu idi. Hastalar›n %60’› ‘muhtemel’ ve %16’s› olas› ilaç alerjisi tan›s› al›rken, yaln›zca %18’inde ilaç alerjisi do¤ruland›.

Çıkarımlar: Ayr›nt›l› ilaç öyküsü, ilaç döküntülerinin tiplerinin bilinmesi ve uygun testler; ilaç döküntüsü olan bir çocu¤un baflar›l› yönetimi için gerekli etkenlerdir.

Anahtar Kelimeler

Amoksisilin/ampisilin, çocuk, eritema mültiforme, “fiks” ilaç döküntüsü, ilaç döküntüsü, ilaç aşırı duyarlılık sendromu, makülopapüler döküntü, ürtiker

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