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Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report

Year 2003, Volume: 11 Issue: 5, 152 - 156, 13.10.2003

Canan Uzel Halil Coşkun Tarık Terzioğlu Necdet Aras

Abstract

A forty-five-year-old female patient presented with thyroid nodules eight years after radical nephrectomy for renal cell carcinoma T2N0M0, grade 2, clear cell subtype in the right kidney. Ultrasonography of the neck showed multiple hypoechoic macronodules. There was no lymphadenomegaly. During total thyroidectomy following an initial diagnosis of multinodular goiter, frozen section analysis was made, which showed metastasis from renal cell carcinoma. Immunohistochemical studies demonstrated that the tumor cells were negative for thyroglobulin staining. No recurrences or other metastatic disease were seen during a follow-up period of 12 months. Although clinically the thyroid gland is a rare site for tumor metastasis, this possibility should be kept in mind in patients with a previous history of renal cell carcinoma

Keywords

Carcinoma/secondary carcinoma renal cell/ secondary/pathology kidney neoplasms/pathology thyroid neoplasms/secondary/surgery thyroidectomy

References

  • Harach HR, Williams ED. Pathology of thyroid cancer. In: Wheeler MH, Lazarus JH, editors. Diseases of the thyroid: pathophysiology and management. 4th ed. London: Chapmann & Hall; 1994. p. 341-8.
  • Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg 1999;23:177-80.
  • Ivy HK. Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clin Proc 1984;59:856-9.
  • Li Volsi VA. Pathology of thyroid disease. In: Falk SE, e d i t o r. Thyroid disease: endocrinology, surg e r y, nuclear medicine, and radiotherapy. 2nd ed. Philadelphia: Lippincott Raven; 1997. p. 127-75.
  • Kocak S. Ender görülen primer tiroit tümörleri ve tiro- ide metastaz yapan kanserler. In: İflgör A, editör. Tiro- it hastalıkları ve cerrahisi. 1. baskı. İstanbul: Avrupa Tıp Yayıncılık; 2000. s. 439-43.
  • Welch K, Finkbeiner W, Alpers CE, Blumenfeld W, Davis RL, Smuckler EA, et al. Autopsy findings in the acquired immune deficiency syndrome. JAMA 1984; 252:1152-9.
  • Lasser A, Rothman JG, Calamia VJ. Renal-cell carcino- ma metastatic to the thyroid. Aspiration cytology and histologic findings. Acta Cytol 1985;29:856-8.
  • Watts NB. Carcinoma metastatic to the thyroid: preva- lence and diagnosis by fine-needle aspiration cytology. Am J Med Sci 1987;293:13-7.
  • Michelow PM, Leiman G. Metastases to the thyroid gland: diagnosis by aspiration cytology. Diagn Cytopathol 1995;13:209-13.
  • McCabe DP, Farrar WB, Petkov TM, Finkelmeier W, O’Dwyer P, James A. Clinical and pathologic correla- tions in disease metastatic to the thyroid gland. Am J Surg 1985;150:519-23.
  • Ericsson M, Biorklund A, Cederquist E, Ingemansson S, Akerman M. Surgical treatment of metastatic dis- ease in the thyroid gland. J Surg Oncol 1981;17:15-23.
  • Czech JM, Lichtor TR, Carney JA, van Heerden JA. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet 1982;155:503-5.

Radikal nefrektomiden sekiz yıl sonra renal hücreli karsinomdan tiroit metastazı: Olgu sunumu

Year 2003, Volume: 11 Issue: 5, 152 - 156, 13.10.2003

Canan Uzel Halil Coşkun Tarık Terzioğlu Necdet Aras

Abstract

Sekiz yıl önce sağ renal hücreli karsinom tanısıyla radikal nefrektomi yapılan T2N0M0grade 2, berrak hücreli subtip 45 yaflında kadın hastada tiroitte no- dül saptandı. Boyun ultrasonografisinde multipl hi- poekoik makronodüler yapı görüldü, lenfadenoma- galiye rastlanmadı. Multinodüler guatr düflünülerek yapılan total tiroidektomi sırasında, frozen ile ince- lenen örnekte renal hücreli karsinom metastazı saptandı. İmmünhistokimyasal analizde, tiroit tü- möründeki berrak hücreler tiroglobulin için boyama göstermedi. Ameliyat sonrasında hastanın 12 aylık izleminde nüks veya baflka metastatik hastalığa rastlanmadı. Tiroit bezinde metastaz çok nadir olsa da, renal hücreli karsinom öyküsü olan hastalarda tiroide metastaz olabileceği göz önünde bulunduru l malıdır

Keywords

Karsinom/ikincil karsinom renal hücreli/ikincil/patoloji böbrek neoplazileri/patoloji tiroit neoplazileri/ikincil/cerrahi tiroidektomi

References

  • Harach HR, Williams ED. Pathology of thyroid cancer. In: Wheeler MH, Lazarus JH, editors. Diseases of the thyroid: pathophysiology and management. 4th ed. London: Chapmann & Hall; 1994. p. 341-8.
  • Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg 1999;23:177-80.
  • Ivy HK. Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clin Proc 1984;59:856-9.
  • Li Volsi VA. Pathology of thyroid disease. In: Falk SE, e d i t o r. Thyroid disease: endocrinology, surg e r y, nuclear medicine, and radiotherapy. 2nd ed. Philadelphia: Lippincott Raven; 1997. p. 127-75.
  • Kocak S. Ender görülen primer tiroit tümörleri ve tiro- ide metastaz yapan kanserler. In: İflgör A, editör. Tiro- it hastalıkları ve cerrahisi. 1. baskı. İstanbul: Avrupa Tıp Yayıncılık; 2000. s. 439-43.
  • Welch K, Finkbeiner W, Alpers CE, Blumenfeld W, Davis RL, Smuckler EA, et al. Autopsy findings in the acquired immune deficiency syndrome. JAMA 1984; 252:1152-9.
  • Lasser A, Rothman JG, Calamia VJ. Renal-cell carcino- ma metastatic to the thyroid. Aspiration cytology and histologic findings. Acta Cytol 1985;29:856-8.
  • Watts NB. Carcinoma metastatic to the thyroid: preva- lence and diagnosis by fine-needle aspiration cytology. Am J Med Sci 1987;293:13-7.
  • Michelow PM, Leiman G. Metastases to the thyroid gland: diagnosis by aspiration cytology. Diagn Cytopathol 1995;13:209-13.
  • McCabe DP, Farrar WB, Petkov TM, Finkelmeier W, O’Dwyer P, James A. Clinical and pathologic correla- tions in disease metastatic to the thyroid gland. Am J Surg 1985;150:519-23.
  • Ericsson M, Biorklund A, Cederquist E, Ingemansson S, Akerman M. Surgical treatment of metastatic dis- ease in the thyroid gland. J Surg Oncol 1981;17:15-23.
  • Czech JM, Lichtor TR, Carney JA, van Heerden JA. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet 1982;155:503-5.
There are 12 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Canan Uzel This is me

Halil Coşkun This is me

Tarık Terzioğlu This is me

Necdet Aras This is me

Publication Date October 13, 2003
Published in Issue Year 2003 Volume: 11 Issue: 5

Cite

APA Uzel, C., Coşkun, H., Terzioğlu, T., Aras, N. (2003). Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report. The Turkish Journal of Ear Nose and Throat, 11(5), 152-156.
AMA Uzel C, Coşkun H, Terzioğlu T, Aras N. Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report. Tr-ENT. October 2003;11(5):152-156.
Chicago Uzel, Canan, Halil Coşkun, Tarık Terzioğlu, and Necdet Aras. “Thyroid Metastasis from Renal Celi Carcinoma Eight Years After Radical Nephrectomy: A Case Report”. The Turkish Journal of Ear Nose and Throat 11, no. 5 (October 2003): 152-56.
EndNote Uzel C, Coşkun H, Terzioğlu T, Aras N (October 1, 2003) Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report. The Turkish Journal of Ear Nose and Throat 11 5 152–156.
IEEE C. Uzel, H. Coşkun, T. Terzioğlu, and N. Aras, “Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report”, Tr-ENT, vol. 11, no. 5, pp. 152–156, 2003.
ISNAD Uzel, Canan et al. “Thyroid Metastasis from Renal Celi Carcinoma Eight Years After Radical Nephrectomy: A Case Report”. The Turkish Journal of Ear Nose and Throat 11/5 (October 2003), 152-156.
JAMA Uzel C, Coşkun H, Terzioğlu T, Aras N. Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report. Tr-ENT. 2003;11:152–156.
MLA Uzel, Canan et al. “Thyroid Metastasis from Renal Celi Carcinoma Eight Years After Radical Nephrectomy: A Case Report”. The Turkish Journal of Ear Nose and Throat, vol. 11, no. 5, 2003, pp. 152-6.
Vancouver Uzel C, Coşkun H, Terzioğlu T, Aras N. Thyroid metastasis from renal celi carcinoma eight years after radical nephrectomy: a case report. Tr-ENT. 2003;11(5):152-6.