Laryngeal leiomyosarcoma with coexistent tuberculous mediastinal lymphadenopathy

Year 2015, Volume: 25 Issue: 2, 113 - 117, 20.05.2015

Nesibe Gül Yüksel Aslıer Ersoy Doğan Sülen Sarıoğlu Ahmet Ömer İkiz

Abstract

Laryngeal leiomyosarcoma is an extremely rare malignancy originating from the smooth muscles of blood vessels. Herein, we present the first case of leiomyosarcoma arising from the glottic area of the larynx with coexistent tuberculous mediastinal lymphadenopathy. The patient was treated with vertical laryngectomy and anti-tuberculous medication. He has been disease-free for 24 months since initial treatment.

Keywords

Larynx, leiomyosarcoma, mediastinal lymphadenopathy, vertical laryngectomy

Eşlik eden tüberküloz mediastinal lenfadenopati ile birlikte larengeal leiomiyosarkom

Abstract

Larengeal leiomiyosarkom, kan damarlarının düz kaslarından köken alan, son derece nadir bir malignitedir. Bu yazıda, eşlik eden tüberküloz mediastinal lenfadenopati ile birliktelik gösteren larenksin glottik bölgesinden köken alan ilk leiomiyosarkom olgusu sunuldu. Hasta vertikal larenjektomi ve antitüberküloz ilaçlar ile tedavi edildi. İlk tedaviden bu yana 24 aydır hasta hastalıksızdır

Keywords

Larenks, leiomiyosarkom, mediastinal lenfadenopati, vertikal larenjektomi

References

• Eeles RA, Fisher C, A’Hern RP, Robinson M, Rhys- Evans P, Henk JM, et al. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer 1993;68:201-7.
• Eppsteiner RW, DeYoung BR, Milhem MM, Pagedar NA. Leiomyosarcoma of the head and neck: a population-based analysis. Arch Otolaryngol Head Neck Surg 2011;137:921-4.
• Chizh GI, Ogorodnikova LS, Birina LM, Ratner ON. Leiomyosarcoma of the larynx in an 8-year-old girl. Vestn Otorinolaringol 1976;5:106-7. [Abstract]
• Völker HU, Zettl A, Haralambieva E, Blume B, Hagen R, Müller-Hermelink HK, et al. Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma-- report of an unusual case. Head Neck 2010;32:679-83.
• Kara E, Cetik MF, Tuncer U, Uguz A. A rare association of leiomyosarcoma with squamous cell carcinoma of the larynx: two cases. J Laryngol Otol 2013;127:828-31.
• Thomas S, McGuff HS, Otto RA. Leiomyosarcoma of the larynx. Case report. Ann Otol Rhinol Laryngol 1999;108:794-6.
• Sasaki T, Ushio M, Okita W, Umemura S. Subglottic leiomyosarcoma of the larynx; a case report. Auris Nasus Larynx 2004;31:165-9.
• Kainuma K, Kikukawa M, Itoh T, Osawa M, Watanabe M. Leiomyosarcoma of the larynx: emergency tracheostomy. J Laryngol Otol 2001;115:570-2.
• Coindre JM. Immunohistochemistry in the diagnosis of soft tissue tumours. Histopathology 2003;43:1-16.
• Miettinen M. Smooth muscle tumors. In: Miettinen M, editor. Modern Soft Tissue Pathology: Tumors and Non-Neoplastic Conditions. 1st ed. New York: Cambridge University Press; 2010. p. 460-77.
• Skoulakis CE, Stavroulaki P, Moschotzopoulos P, Paxinos M, Fericean A, Valagiannis DE. Laryngeal leiomyosarcoma: a case report and review of the literature. Eur Arch Otorhinolaryngol 2006;263:929-34.
• Cocks H, Quraishi M, Morgan D, Bradley P. Leiomyosarcoma of the larynx. Otolaryngol Head Neck Surg 1999;121:643-6.
• Tomidokoro Y, Hayashi R, Yamasaki M, Ishii G, Kamijo T, Ebihara S. Simultaneous squamous cell carcinoma with leiomyosarcoma of the larynx. Auris Nasus Larynx 2009;36:239-43.
• Marioni G, Bertino G, Mariuzzi L, Bergamin- Bracale AM, Lombardo M, Beltrami CA. Laryngeal leiomyosarcoma. J Laryngol Otol 2000;114:398-401.
• Paczona R, Jóri J, Tiszlavicz L, Czigner J. Leiomyosarcoma of the larynx. Review of the literature and report of two cases. Ann Otol Rhinol Laryngol 1999;108:677-82.
• Karasalihoğlu A, Sarıkahya İ, Kutlu K, Koten M, Yaşar H, Adalı MK. Larenks leiomyosarkomu (İki olgu takdimi ve literatür taraması). Türk Otorinolarengoloji Arşivi 1989;27:145-7.