Antiproliferative effect of silver compounds containing benzimidazole ring

Year 2025, Issue: Online First

Dilek Bahar , Senem Akkoç , Buket Banu Özkan

https://doi.org/10.23902/trkjnat.1549105

Abstract

With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine. Recent studies have focused on the synthesis and biological activity of benzimidazole compounds. Therefore, this study prepared a series of N-heterocyclic silver compounds containing benzimidazole nuclei. These complexes were cultured with lung (A549), colon (CaCo2), breast (MCF7), prostate (PC3) cancer cell lines, and healthy lung (WI38) cell line, and their anticancer effects were investigated through MTT, apoptosis determination, and oxidative stress tests. The results revealed that the presence of drug candidates was more practical than that of commercially used cisplatin.

Keywords

Apoptosis, cytotoxic activity, Ag-NHC, oxidative stress.

Ethical Statement

Since the article does not contain any studies with human or animal subject, its approval to the ethics committee was not required.

Supporting Institution

Erciyes University Research Fund

Project Number

TKB-2020-10346

Thanks

We would like to thank GENKOK, Erciyes University Research Fund (Eru BAP) and the Proofreading & Editing Office of the Dean for Research of Erciyes University for copyediting and proofreading service for an earlier version of the manuscript.

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