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Year 2025, Volume: 26 Issue: 2, 127 - 134, 15.10.2025

Hüseyin Servi , Timur Hakan Barak , Ali Şen , Simge Ertekin , Hüseyin Türker , Bengü Türkyılmaz Ünal , Cemil İşlek

Abstract

Hypericum cinsi, tıbbi ve kozmetik faydaları olan fitokimyasallar bakımından zengin olması nedeniyle Türkiye florası için önemli bir cinstir. Hypericum bilgehan-bilgilii Basköse & Savran'ın (HEO)’nin uçucu yağ bileşimi ve biyolojik aktiviteleri bu çalışmada ilk kez analiz edilmiştir. Hypericum bilgehan-bilgilii tüm kısımlarının uçucu yağı, Clevenger tipi aparatla hidrodistilasyon yoluyla elde edilmiştir. Kimyasal bileşim, polar olmayan kolon kullanılarak GC-MS ile analiz edilmiştir. α-glukozidaz ve 5-lipoksijenaz inhibitör, sitotoksik ve DPPH radikal süpürücü aktiviteleri araştırılmıştır. Kırk sekiz bileşen tanımlanmış ve tüm bileşenlerin %97,3'ünü temsil etmiştir. İlginç bir şekilde, majör uçucular: 1-(2,4,5-trimetoksifenil)bütan-1-on (%27,7) ve 3-Metil-1-(2,4,6-trihidroksifenil)bütan-1-on (%11,2) Hypericum uçucu yağlarında ilk kez tespit edilmiştir. Yağ, 39 µg/mL'lik bir IC50 değeriyle 5-lipoksijenaz enzimine karşı önemli bir aktivite göstermiştir. HEO'nun sitotoksisite potansiyeli, farklı konsantrasyonlarda, dört hücre hattına karşı araştırılmış ve IC50 değerleri hafif sitotoksisitenin varlığını göstermiştir. Bu sonuçlar, H. bilgehan-bilgilii uçucu yağının biyoaktif bileşenler ve anti-inflamatuar ajanlar için değerli bir kaynak olarak kabul edilebileceğini göstermiştir.

Ethical Statement

The manuscript does not include any studies on human or animal topics. Ethics committee approval is not required.

Supporting Institution

No external funding acquired.

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Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials

Year 2025, Volume: 26 Issue: 2, 127 - 134, 15.10.2025

Hüseyin Servi , Timur Hakan Barak , Ali Şen , Simge Ertekin , Hüseyin Türker , Bengü Türkyılmaz Ünal , Cemil İşlek

Abstract

Hypericum L. is a significantly important genus for flora of Türkiye due to its richness in phytochemicals possessing medicinal and cosmetic benefits. The essential oil composition and biological activities of Hypericum bilgehan-bilgilii Basköse & Savran (HEO) were analysed for the first time in the present study. The volatile oil of the whole parts of H. bilgehan-bilgilii was obtained by hydrodistillation with Clevenger-type apparatus. The chemical composition was analyzed by GC-MS using non-polar column. α-glucosidase and 5-lipoxygenase inhibitory, cytotoxic, and DPPH radical scavenging activities were investigated. Forty-eight components were identified and represented 97.3% of the whole constituents. Interestingly, the major volatiles: 1-(2,4,5-trimethoxyphenyl)butan-1-one (27.7%) and 3-Methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one (11.2%) were detected for the first time in Hypericum essential oils. The oil exhibited a significant activity against the 5-lipoxygenase enzyme with an IC50 value of 39 µg/mL. Cytotoxicity potential of HEO was investigated, at different concentrations, towards four cell lines and, IC50 values underlies mild cytotoxicity. These results indicated that H. bilgehan-bilgilii essential oil may be considered as a valuable source for bioactive ingredients and anti-inflammatory agents.

Keywords

Aromatherapy Gas Chromatography-Mass Spectrometry GC-FID Bioactivity Hypericum bilgehan-bilgilii

Ethical Statement

Since the article does not contain any studies with human or animal subject, its approval to the ethics committee was not required.

References

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  • Crockett, S. L., Wenzig, E. M., Kunert, O., & Bauer R. (2008). Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium. Phytochemistry Letters, 1(1), 37-43. https://doi.org/10.1016/j.phytol.2007.12.003
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  • Ersoy, E., Ozkan, E. E., Boga, M., Yilmaz, M. A., & Mat, A. (2019). Anti-aging potential and anti-tyrosinase activity of three Hypericum species with focus on phytochemical composition by LC–MS/MS. Industrial Crops and Products, 141, 111735. https://doi.org/10.1016/j.indcrop.2019.111735
  • Ertosun, G. B., Ergen, M., Bardakcı, H., Barak, T. H., & Suyen, G. (2023). Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats. Marmara Medical Journal, 36(3), 361-370. https://doi.org/10.5472/marumj.1368345
  • Fenanir, F., Semmeq, A., Benguerba, Y., Badawi, M., Dziurla, M. A., Amira, S., & Laouer, H. (2022). In silico investigations of some Cyperus rotundus compounds as potential anti-inflammatory inhibitors of 5-LO and LTA4H enzymes. Journal of Biomolecular Structure and Dynamics, 40(22), 11571-11586. https://doi.org/10.1080/07391102.2021.1960197
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There are 49 citations in total.

Details

Primary Language English
Subjects Botany (Other)
Journal Section Research Article/Araştırma Makalesi
Authors

Hüseyin Servi 0000-0002-4683-855X

Timur Hakan Barak 0000-0002-7434-3175

Ali Şen 0000-0002-2144-5741

Simge Ertekin 0000-0002-7976-7057

Hüseyin Türker 0000-0001-7309-9484

Bengü Türkyılmaz Ünal 0000-0003-4003-5200

Cemil İşlek 0000-0002-6690-2846

Early Pub Date July 10, 2025
Publication Date October 15, 2025
Submission Date February 6, 2025
Acceptance Date June 13, 2025
Published in Issue Year 2025 Volume: 26 Issue: 2

Cite

APA Servi, H., Barak, T. H., Şen, A., … Ertekin, S. (2025). Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials. Trakya University Journal of Natural Sciences, 26(2), 127-134.
AMA Servi H, Barak TH, Şen A, et al. Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials. Trakya Univ J Nat Sci. October 2025;26(2):127-134.
Chicago Servi, Hüseyin, Timur Hakan Barak, Ali Şen, Simge Ertekin, Hüseyin Türker, Bengü Türkyılmaz Ünal, and Cemil İşlek. “Chemical Composition of Endemic Hypericum Bilgehan-Bilgilii Basköse & Savran Essential Oil and Its α-Glucosidase Antidiabetic, Anti-Inflammatory, Cytotoxic and Antioxidant Potentials”. Trakya University Journal of Natural Sciences 26, no. 2 (October 2025): 127-34.
EndNote Servi H, Barak TH, Şen A, Ertekin S, Türker H, Türkyılmaz Ünal B, İşlek C (October 1, 2025) Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials. Trakya University Journal of Natural Sciences 26 2 127–134.
IEEE H. Servi, T. H. Barak, A. Şen, S. Ertekin, H. Türker, B. Türkyılmaz Ünal, and C. İşlek, “Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials”, Trakya Univ J Nat Sci, vol. 26, no. 2, pp. 127–134, 2025.
ISNAD Servi, Hüseyin et al. “Chemical Composition of Endemic Hypericum Bilgehan-Bilgilii Basköse & Savran Essential Oil and Its α-Glucosidase Antidiabetic, Anti-Inflammatory, Cytotoxic and Antioxidant Potentials”. Trakya University Journal of Natural Sciences 26/2 (October2025), 127-134.
JAMA Servi H, Barak TH, Şen A, Ertekin S, Türker H, Türkyılmaz Ünal B, İşlek C. Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials. Trakya Univ J Nat Sci. 2025;26:127–134.
MLA Servi, Hüseyin et al. “Chemical Composition of Endemic Hypericum Bilgehan-Bilgilii Basköse & Savran Essential Oil and Its α-Glucosidase Antidiabetic, Anti-Inflammatory, Cytotoxic and Antioxidant Potentials”. Trakya University Journal of Natural Sciences, vol. 26, no. 2, 2025, pp. 127-34.
Vancouver Servi H, Barak TH, Şen A, Ertekin S, Türker H, Türkyılmaz Ünal B, et al. Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials. Trakya Univ J Nat Sci. 2025;26(2):127-34.

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