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High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia

Year 2025, Volume: 6 Issue: 3, 97 - 99, 30.09.2025

Abstract

Benign transient hyperphosphatasemia (BTH) is a self-limited condition of early childhood, defined by a transient elevation of serum alkaline phosphatase (ALP) without evidence of underlying disease. This report emphasizes the importance of considering BTH in the differential diagnosis of elevated ALP and presents a case in light of the current literature. Recognition of BTH is crucial to prevent unnecessary investigations and referrals in pediatric practice.

References

  • 1. Solé-Enrech G, Cano-Corres R, Nuez-Zaragoza E, Pine- da-Solas V, Berlanga-Escalera E. Benign transient hyperp- hosphatasemia: Two case reports. Clin Biochem. 2021 May;91:67-69. doi: 10.1016/j.clinbiochem.2021.01.015. Epub 2021 Feb 9. PMID: 33571512.
  • 2. Sakurai Y, Higashiguchi T. Transient hyperphosphatase- mia: Possible association with pediatric acute respiratory infection. Pediatr Investig. 2021 Jun 18;5(2):94-98. doi: 10.1002/ped4.12265. PMID: 34179704; PMCID: PMC8212759.
  • 3. Zhan F, Watanabe Y, Shimoda A, Hamada E, Kobayashi Y, Maekawa M. Evaluation of serum bone alkaline phospha- tase activity in patients with liver disease: Comparison between electrophoresis and chemiluminescent enzyme immunoassay. Clin Chim Acta. 2016 Sep 1;460:40-5. doi: 10.1016/j.cca.2016.06.008. Epub 2016 Jun 9. PMID: 27291655.
  • 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Iso- enzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child. 1985 Jul;139(7):736-40. doi: 10.1001/archpedi.1985.02140090098042. PMID: 4014098.
  • 5. Chu AS, Rothschild JG. Update on Benign Transient Hyperphosphatasemia: Recognizing an Underappreciated Condition. Clin Pediatr (Phila). 2016 Jun;55(6):564-6. doi: 10.1177/0009922815593908. Epub 2015 Jul 7. PMID: 26156974.
  • 6. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr. 2013 Aug;57(2):167-71. doi: 10.1097/MPG.0b013e3182922807. PMID: 23539049.
  • 7. Shkalim Zemer V , Hoshen M, Levinsky Y , Richenberg Y , Yosef N, Oberman B, et al. Benign transient hyperphospha- tasemia in infants and children: a retrospective database study. Eur J Pediatr. 2023 Jul;182(7):3211-3216. doi: 10.1007/s00431-023-04995-1. Epub 2023 May 2. PMID: 37127797; PMCID: PMC10151212.
  • 8. Erat T, Atar M, Kontbay T. Transient benign hyperp- hosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab. 2020 Dec 14;34(3):385-387. doi: 10.1515/jpem-2020-0503. PMID: 33577728.
  • 9. Akcaboy M, Zorlu P, Acoglu EA, Acar M, Oguz MM, Senel S. Human Bocavirus Infection Associated Transient Benign Hyperphosphatasemia in an Infant. Indian J Pediatr. 2016 Aug;83(8):902-3. doi: 10.1007/s12098-016-2156-5. Epub 2016 Jun 1. PMID: 27246826.
  • 10. Tchidjou HK, Caron F, Ferec A, Braun K, Hery L, Cas- telain S, et al. Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children. Blood Coagul Fibrinolysis. 2020 Dec;31(8):575-577. doi: 10.1097/MBC.0000000000000954. PMID: 32897891.
  • 11. Rasheed E, Mayne P. Transient Hyperphosphatasaemia of Infancy: An Often Unrecognised and Thus Over- Investigated Condition. Ir Med J. 2016 Apr 11;109(4):392.

Yüksek alkalen fosfataz değeriyle başvuran sağlıklı bir çocuk: benign geçici hiperfosfatazemi olgusu

Year 2025, Volume: 6 Issue: 3, 97 - 99, 30.09.2025

Abstract

Benign geçici hiperfosfatazemi (BGH), erken çocukluk döneminde görülen, altta yatan herhangi bir hastalık bulgusu olmaksızın serum alkalen fosfataz (ALP) düzeylerinde geçici yükselme ile karakterize, kendini sınır- layan bir durumdur. Bu olgu sunumu, artmış ALP düzeylerinin ayırıcı tanısında BGH’nin göz önünde bulun- durulmasının önemini vurgulamakta ve mevcut literatür ışığında bir olguyu sunmaktadır. BGH’nin tanınması, çocukluk çağında gereksiz tetkik ve yönlendirmelerin önlenmesi açısından büyük önem taşımaktadır.

References

  • 1. Solé-Enrech G, Cano-Corres R, Nuez-Zaragoza E, Pine- da-Solas V, Berlanga-Escalera E. Benign transient hyperp- hosphatasemia: Two case reports. Clin Biochem. 2021 May;91:67-69. doi: 10.1016/j.clinbiochem.2021.01.015. Epub 2021 Feb 9. PMID: 33571512.
  • 2. Sakurai Y, Higashiguchi T. Transient hyperphosphatase- mia: Possible association with pediatric acute respiratory infection. Pediatr Investig. 2021 Jun 18;5(2):94-98. doi: 10.1002/ped4.12265. PMID: 34179704; PMCID: PMC8212759.
  • 3. Zhan F, Watanabe Y, Shimoda A, Hamada E, Kobayashi Y, Maekawa M. Evaluation of serum bone alkaline phospha- tase activity in patients with liver disease: Comparison between electrophoresis and chemiluminescent enzyme immunoassay. Clin Chim Acta. 2016 Sep 1;460:40-5. doi: 10.1016/j.cca.2016.06.008. Epub 2016 Jun 9. PMID: 27291655.
  • 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Iso- enzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child. 1985 Jul;139(7):736-40. doi: 10.1001/archpedi.1985.02140090098042. PMID: 4014098.
  • 5. Chu AS, Rothschild JG. Update on Benign Transient Hyperphosphatasemia: Recognizing an Underappreciated Condition. Clin Pediatr (Phila). 2016 Jun;55(6):564-6. doi: 10.1177/0009922815593908. Epub 2015 Jul 7. PMID: 26156974.
  • 6. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr. 2013 Aug;57(2):167-71. doi: 10.1097/MPG.0b013e3182922807. PMID: 23539049.
  • 7. Shkalim Zemer V , Hoshen M, Levinsky Y , Richenberg Y , Yosef N, Oberman B, et al. Benign transient hyperphospha- tasemia in infants and children: a retrospective database study. Eur J Pediatr. 2023 Jul;182(7):3211-3216. doi: 10.1007/s00431-023-04995-1. Epub 2023 May 2. PMID: 37127797; PMCID: PMC10151212.
  • 8. Erat T, Atar M, Kontbay T. Transient benign hyperp- hosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab. 2020 Dec 14;34(3):385-387. doi: 10.1515/jpem-2020-0503. PMID: 33577728.
  • 9. Akcaboy M, Zorlu P, Acoglu EA, Acar M, Oguz MM, Senel S. Human Bocavirus Infection Associated Transient Benign Hyperphosphatasemia in an Infant. Indian J Pediatr. 2016 Aug;83(8):902-3. doi: 10.1007/s12098-016-2156-5. Epub 2016 Jun 1. PMID: 27246826.
  • 10. Tchidjou HK, Caron F, Ferec A, Braun K, Hery L, Cas- telain S, et al. Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children. Blood Coagul Fibrinolysis. 2020 Dec;31(8):575-577. doi: 10.1097/MBC.0000000000000954. PMID: 32897891.
  • 11. Rasheed E, Mayne P. Transient Hyperphosphatasaemia of Infancy: An Often Unrecognised and Thus Over- Investigated Condition. Ir Med J. 2016 Apr 11;109(4):392.
There are 11 citations in total.

Details

Primary Language English
Subjects Infant and Child Health, Pediatric Endocrinology
Journal Section Articles
Authors

Samet Can Tekin 0009-0006-3651-4590

Tolga Kasap 0000-0002-1046-7638

Publication Date September 30, 2025
Submission Date August 18, 2025
Acceptance Date September 23, 2025
Published in Issue Year 2025 Volume: 6 Issue: 3

Cite

APA Tekin, S. C., & Kasap, T. (2025). High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia. Troia Medical Journal, 6(3), 97-99. https://doi.org/10.55665/troiamedj.1767889
AMA Tekin SC, Kasap T. High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia. Troia Med J. September 2025;6(3):97-99. doi:10.55665/troiamedj.1767889
Chicago Tekin, Samet Can, and Tolga Kasap. “High Alkaline Phosphatase Level in a Healthy Child: A Case of Benign Transient Hyperphosphatasemia”. Troia Medical Journal 6, no. 3 (September 2025): 97-99. https://doi.org/10.55665/troiamedj.1767889.
EndNote Tekin SC, Kasap T (September 1, 2025) High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia. Troia Medical Journal 6 3 97–99.
IEEE S. C. Tekin and T. Kasap, “High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia”, Troia Med J, vol. 6, no. 3, pp. 97–99, 2025, doi: 10.55665/troiamedj.1767889.
ISNAD Tekin, Samet Can - Kasap, Tolga. “High Alkaline Phosphatase Level in a Healthy Child: A Case of Benign Transient Hyperphosphatasemia”. Troia Medical Journal 6/3 (September2025), 97-99. https://doi.org/10.55665/troiamedj.1767889.
JAMA Tekin SC, Kasap T. High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia. Troia Med J. 2025;6:97–99.
MLA Tekin, Samet Can and Tolga Kasap. “High Alkaline Phosphatase Level in a Healthy Child: A Case of Benign Transient Hyperphosphatasemia”. Troia Medical Journal, vol. 6, no. 3, 2025, pp. 97-99, doi:10.55665/troiamedj.1767889.
Vancouver Tekin SC, Kasap T. High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia. Troia Med J. 2025;6(3):97-9.