Rekürren Arteriyel ve Venöz Trombozun İlk Bulgusu Olarak Saptanan Endometrioid Adenokarsinom: Olgu Sunumu

Abstract

Amaç: Kanserle bağlantılı tromboz hem venöz hem de arteriyel sistemlerde görülebilir ve bazı durumlarda altta yatan kanserin ilk işareti olabilir. Bu çalışmada, tekrarlayan kombine arteriyel ve venöz tromboz ile başvuran bir hastanın daha sonra endometrioid adenokarsinom tanısı aldığı bir olgu sunulmuştur.

Olgu: Malignite öyküsü olmayan, multipar, 50 yaşındaki bir kadın hasta Mart 2025’te tekrar eden serebral trombotik olaylarla başvurdu. Antiplatelet ve antikoagülan tedaviye rağmen trombotik olaylar devam etti. Kasım 2025’te derin ven trombozu ile birlikte pulmoner emboli gelişti. Bu dönemde yoğun anormal uterus kanama gözlemlendi. Abdominal manyetik rezonans görüntüleme posterior yerleşimli uterin kitle gösterdi. Endometrial biyopsi endometrioid adenokarsinom tanısını doğruladı. Cerrahi patoloji, <%50 miyometriyal invazyon ve bilateral over tutulumu olan FIGO evre IIIA, Grade 2 endometrioid karsinom ile uyumluydu.

Sonuç: Rekürren ve kombine arteriyel-venöz tromboz, yeterli antikoagülan tedaviye rağmen devam ediyorsa gizli bir malignite açısından daha detaylı bir inceleme gerektirir. Eşlik eden anormal uterin kanama varlığında endometrial malignite mutlaka dışlanmalıdır.

Keywords

• Endometrioid adenokarsinom
• Malignite ilişkili tromboz
• Arteryel tromboz
• Venöz tromboembolizm

Supporting Institution

Bu çalışma herhangi bir kurum veya kuruluş tarafından desteklenmemiştir.

Ethical Statement

Bu çalışma tek olgu sunumu niteliğinde olduğundan etik kurul onayı gerekmemiştir. Hastadan yayın için yazılı aydınlatılmış onam alınmıştır.

Thanks

Teşekkür bölümü bulunmamaktadır.

Cancer-Associated Recurrent Arterial and Venous Thrombosis Leading to the Diagnosis of Endo- metrioid Adenocarcinoma: A Case Report

Abstract

Objective: Cancer-associated thrombosis may affect both the venous and arterial systems and, in some cases, may represent the first manifestation of an underlying malignancy. In this study, we present a case of recurrent combined arterial and venous thrombosis that led to the diagnosis of endometrioid adenocarcinoma.

Case: A 50-year-old multiparous woman with no history of malignancy presented in March 2025 with recurrent cerebral thrombotic events. Despite antiplatelet and anticoagulant therapy, thrombotic events persisted. In November 2025, pulmonary embolism developed with deep vein thrombosis. During this period, heavy abnormal uterine bleeding was observed. Abdominal magnetic resonance imaging showed a posteriorly located uterine mass. Endometrial biopsy confirmed the diagnosis of endometrioid adenocarcinoma. Surgical pathology was consistent with FIGO stage IIIA, Grade 2 endometrioid carcinoma with <50% myometrial invasion and bilateral ovarian involvement.

Conclusion: Recurrent and combined arterial-venous thrombosis requires further investigation for occult malignancy if it persists despite adequate anticoagulation therapy. In the presence of accompanying abnormal uterine bleeding, endometrial malignancy must be ruled out.
 

Keywords

• Endometrioid adenocarcinoma
• Cancer-associated thrombosis
• Arterial thrombosis
• Venous thromboembolism

Supporting Institution

This study received no financial support.

Ethical Statement

Ethics committee approval was not required due to the nature of the study as a single case report. Written informed consent was obtained from the patient for publication.

Thanks

There is no acknowledgement

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