BASİT HİSTEREKTOMİ SONRASI TANI ALAN SERVİKS KANSERLERİNE GÜNCEL YAKLAŞIM

Abstract

Servikal kanser, tüm dünyada jinekolojik kanserlere bağlı ölümlerin önde gelen nedenlerindendir. Pap smear taramasının yaygın kullanımı ile servikal kanser erken tanısı artmaktadır. Ancak, ihmalden ya da olguların yetersiz değerlendirilmesinden dolayı servikal kanser tanısı retrospektif olarak histerektomi sonrası konabilmektedir. Radikal parametrektomi ve radyoterapi, basit histerektomi sonrası tanı alan servikal kanser olgularındaki iki tedavi modalitesidir. Bu çalışmada, histerektomi sonrası tanı alan servikal kanser olgularının nedenleri, tedavi modaliteleri ve prognozları hakkında kapsamlı bilgi vermeyi hedefledik.

Keywords

• servikal kanser, basit histerektomi, radikal parametrektomi, radyoterapi

UP-TO DATE: APPROACH TO CERVICAL CANCER DIAGNOSED AFTER SIMPLE HYSTERECTOMY

Abstract

Cervical cancer is one of the leading causes of gynecological cancer deaths in the world. Early diagnosis of cervical cancer has increased with the widespread Pap smear screening. However, cervical cancer cases can be diagnosed restrospectively posthystrectomy due to inappropriate evaluation of the cases or ignorence. Radical parametrectomy and radiation therapy are the two treatment modalities used to treat cervical cancer cases diagnosed after simple hysterectomy. In the present study, we aimed to give comprehensive information about the causes of cervical cancer cases diagnosed post-hysterectomyly, treatment modalities and prognosis

Keywords

• cervical cancer, simple hysterectomy, radikal parametrectomy, radiation therapy

References

1. 1. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. International Agency for Research on Cancer: Lyon, France; 2010.
2. 2. S. Pecorelli, L. Zigliani, F. Odicino. Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet. 2009;105:107–08.
3. 3. Covens, B. Rosen, J. Murphy, S. Laframboise, A.D. DePetrillo, G. Lickrishet al.Changes in the demographics and perioperative care of stage IA(2)/IB(1) cervical cancer over the past 16 years. Gynecol Oncol. 2001;81:133–37
4. 4. M.A. Quinn, J.L. Benedet, F. Odicino, P. Maisonneuve, U. Beller, W.T. Creasman et al.Carcinoma of the cervix uteri. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95:S43–S103
5. 5. National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN GuidelinesTM) - [cited 2013 Jan 14].
6. 6. Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Management of occult invasive cervical cancer found after simple hysterectomy. AnnOncol 2010;21:994–00.
7. 7. Munstedt K, Johnson P, von Georgi R, Vahrson H, Tinneberg HR. Consequences of inadvertent, suboptimal primary surgery in carcinoma of the uterine cervix. Gynecol Oncol 2004;94:515–20.
8. 8. Rodolakis A, Diakomanolis E, Haidopoulos D, Voulgaris Z, Protopapas A, Makris N, et al. How to avoid suboptimal management of cervical carcinoma by simple hysterectomy. Eur J Gynaecol Oncol 1999;20:418– 22.

9. 9. Behtash N, Mousavi A, Mohit M, Modares M, Khanafshar N, Hanjani P. Simple hysterectomy in the presence of invasive cervical cancer in Iran. Int J Gynecol Cancer 2003;13:177– 81.
10. 10. Srisomboon J, Pantusart A, Phongnarisorn C, Suprasert P. Reasons for improper simple hysterectomy in patients with invasive cervical cancer in the northern region of Thailand. J Obstet Gynaecol Res 2000;26: 175–80.
11. 11. Charles A. Leath III, J. Michael Straughn Jr., Snehal M. Bhoola, Edward E. Partridge, Larry C. Kilgore, and Ronald D. Alvarez. The role of radical parametrectomy in the treatment of occult cervical carcinoma after extrafascial hysterectomy. Gynecologic Oncology 2004;92: 215– 19
12. 12. Ayhan A, Otegen U, Guven S, Kucukali T. Radical reoperation for invasive cervical cancer found in simple hysterectomy. J Surg Oncol 2006;94:28–4.
13. 13. Dong Hoon Suh, Hyun Hoon Chung, Jae Weon Kim, Noh Hyun Park, Yong Sang Song, Soon-Beom Kang, An Occult Invasive Cervical Cancer Found After a Simple Hysterectomy: A 10-Year Experience in a Single Institution. Int J Gynecol Cancer 2011;21: 1646-53.
14. 14. Morris M. Management of stage IA cervical carcinoma. J Natl Cancer Inst Monogr 1996;47– 2.
15. 15. van Nagell Jr JR, Greenwell N, Powell DF, Donaldson ES, Hanson MB, Gay EC. Microinvasive carcinoma of the cervix. Am J Obstet Gynecol 1983;145:981–91.
16. 16. Schorge JO, Lee KR, Flynn CE, Goodman A, Sheets EE. Stage IA1 cervicaladenocarcinoma: defi nition and treatment. Obstet Gynecol 1999;93:219–22.
17. 17. Choi DH, Huh SJ, Nam KH. Radiation therapy results for patients undergoing inappropriate surgery in the presence of invasive cervical carcinoma. Gynecol Oncol. 1997;65:506-11.
18. 18. Daniel W, Brunschwig A. The management of recurrent carcinoma of the cervix following simple total hysterectomy. Cancer 1961;14: 582–6.
19. 19. Gemer O, Eitan R, Gdalevich M, Mamanov A, Piura B, Rabinovich A, Levavi H, Saar-Ryss B, Halperin R, Finci S, Beller U, Bruchim I, Levy T, Ben Shachar I, Ben Arie A, Lavie O. Can parametrectomy be avoided in early cervical cancer? An algorithm for the identifi cation of patients at low risk for parametrial involvement.Eur J SurgOncol. 2013;39(1):76-0
20. 20. Frumovitz M, Sun CC, Schmeler KM, et al. Parametrial involvement in radical hysterectomy specimens for women with early-stage cervical cancer. Obstet Gynecol 2009;114:93–9.
21. 20. Kodama J, Kusumoto T, Nakamura K, Seki N, Hongo A, Hiramatsu Y. Factors associated with parametrial involvement in stage IB1 cervical cancer and identifi cation of patients suitable for less radical surgery. Gynecol Oncol 2011;122(3):491–94
22. 22. Kinney WK, Egorshin EV, Ballard DJ, Podratz KC. Longterm survival and sequel after surgical management of invasive cervical carcinoma diagnosed at the time of simple hysterectomy. Gynecol Oncol 1992;44:24 – 7.
23. 23. Covens A, Rosen B, Murphy J, et al. How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol 2002;84:145–9.
24. 24. Orr JW, Ball GC, Soong SJ, Hatch KD, Partridge EE, Austin JM. Surgical treatment of women found to have invasive cervix cancer at the time of total hysterectomy. Obstet Gynecol 1986;68:353– 6.
25. 25. Chapman JA, Mannel RS, DiSaia PJ, et al. Surgical treatment of unexpected invasive cervical cancer found at total hysterectomy. Obstet Gynecol. 1992;80:931-934.
26. 26. Magrina JF, Walter AJ, Schild SE. Laparoscopic radical parametrectomy and pelvic and aortic lymphadenectomy for vaginal carcinoma: a case report. Gynecol Oncol 1999;75:514– 6.
27. 27. Alessandro Buda, Antonio Pellegrino, Domenico Vitobello, Mario Giuseppe Meroni, Dario Recalcati, Patrizia Perego. Total laparoscopic radical parametrectomy, partial colpectomy, and pelvic lymphadenectomy in patients with occult cervical cancer. International Journal of Gynecology and Obstetrics 2009;107:73–6.
28. 28. Li J, Xu H, Chen Y, Wang D, Li Y, Liang Z. Laparoscopic nerve-sparing radical parametrectomy for occult earlystage invasive cervical cancer after simple hysterectomy. Int J Gynecol Cancer. 2012;22(8):1383-8.
29. 29. Ramirez PT, Schmeler KM, Wolf JK, et al. Robotic radical parametrectomy and pelvic lymphadenectomy in patients with invasive cervical cancer. Gynecol Oncol. 2008;111:18-21
30. 30. Fleisch MC, Hatch KD. Laparoscopic assisted parametrectomy/ upper vaginectomy (LPUV)Vtechnique, applications and results. Gynecol Oncol. 2005;98:420-426.
31. 30. Lee CL, Huang KG. Total laparoscopic radical parametrectomy. J Minim Invasive Gynecol. 2005;12:168-170.
32. 31. Lee YS, Lee TH, Koo TB, et al. Laparoscopic-assisted radical parametrectomy including pelvic and/or paraaortic lymphadenectomy in women after prior hysterectomyVthree cases. Gynecol Oncol. 2003;91:619-622.
33. 33. Chen SW, Liang JA, Yang SN, et al. Postoperative radiotherapy for patients with invasive cervical cancer following treatment with simple hysterectomy. Jpn J Clin Oncol. 2003;33:477-481.
34. 34. Chang SJ, Kim WY, Yoo SC, et al. A validation study of new risk grouping criteria for postoperative treatment in stage IB cervical cancers without high-risk factors: rethinking the Gynecologic Oncology Group criteria. Eur J Obstet Gynecol Reprod Biol. 2009;147:91-96.
35. 35. Smith KB, Amdur RJ, Yeung AR, Morris CG, Kirwan J, Morgan LS. Postoperative radiotherapy for cervix cancer incidentally discovered after a simple hysterectomy for either benign conditions or noninvasive pathology. Am J Clin Oncol 2010;33:229–32.
36. 36. Saibishkumar EP, Patel FD, Ghoshal S, et al. Results of salvage radiotherapy after inadequate surgery in invasive cervical carcinoma patients: A retrospective analysis. IntJ Radiat Oncol Biol Phys. 2005;63:828-33.
37. 37. Gori JR, Fritsches HG, Castanno R, et al. Radical parametrectomy for occult cervical carcinoma detected posthysterectomy. J Low Genit Tract Dis. 2004;8:102-05.
38. 38. L.D. Roman, M. Morris, M.F. Mitchell, P.J. Eifel, T.W. Burke, E.N. Atkinson Prognostic factors for patients undergoing simple hysterectomy in the presence of invasive cancer of the cervix. Gynecol Oncol. 1993;50:179–84.
39. 39. Hsu WL, Shueng PW, Jen YM, et al. Long-term treatment results of invasive cervical cancer patients undergoing inadvertent hysterectomy followed by salvage radiotherapy. Int J Radiat Oncol Biol Phys. 2004;59:521-27.
40. 40. Hamberger AD, Unal A, Gershenson DM, Fletcher GH. Analysis of the severe complications of irradiation of carcinoma of the cervix: whole pelvis irradiation and intracavitary radium. Int J RadiatOncolBiolPhys 1983;9:367- 71.