The Effect of Neutrophil Lymphocyte Ratio on Prognosis of Ovarian Cancer.

Abstract

Objective: In this study, we planned to investigate the association between neutrophil lymphocyte ratio (NLR) and prognosis in ovarian cancer. Materials And Methods: The data of 84 patients who were followed up at Manisa Celal Bayar University Medical Oncology Clinic between May 2011 and November 2018 were analyzed retrospectively. NLR was calculated by dividing absolute neutrophil count by absolute lymphocyte count. The cut-off value of NLR was 4.2 according to the result of ROC analysis and the patients were divided into two groups as <4.2 and ≥4.2. These groups were compared with regard to overall survival (OS) and progression free survival (PFS) rates. Results: Preoperative neutrophil and lymphocyte values were examined from 71 of 84 patients. OS in all study population was 20 months (95% CI: 8,3-31,6, std: 5,9). There was no significant difference between two groups in OS rates (p: 0.279). PFS of 47 (66%) patients with an NLR of less than 4.2 was found to be 31 months and PFS was 21 months in 27 (29.2%) patients with a value higher than 4.2, and was statistically significant (p ; 0,010). Conclusion: The results of our study indicate that pre-treatment high NLR is associated with poor prognosis in ovarian cancer patients.

Keywords

• Ovarian Cancer,Neutrophil Lymphocyte Ratio,Prognosis

Nötrofil Lenfosit Oranının Over Kanserinin Prognozuna Etkisi.

Abstract

Amaç: Bu çalışmada over kanserinde nötrofil lenfosit oranı (NLR) ile prognoz arasındaki ilişkiyi araştırmayı planladık. Gereç ve Yöntem: Mayıs 2011-Kasım 2018 tarihleri arasında Manisa Celal Bayar Üniversitesi Tıbbi Onkoloji Kliniğinde takip edilen 84 hastanın verileri retrospektif olarak incelendi. NLR, mutlak nötrofil sayısının mutlak lenfosit sayısına bölünmesiyle hesaplanmıştır. ROC analizi sonucuna göre NLR'nin cut-off değeri 4.2 idi ve hastalar <4.2 ve >4.2 olarak iki gruba ayrıldı. Bu gruplar genel sağkalım (OS) ve progresyonsuz sağkalım (PFS) oranları açısından karşılaştırıldı. Bulgular: 84 hastanın 71'inde preoperatif nötrofil ve lenfosit değerleri incelendi. Tüm çalışma popülasyonunda OS 20 aydı (% 95 GA: 8,3-31,6, std: 5,9). İki grup arasında OS oranları arasında anlamlı fark yoktu (p: 0.279). NLR'si 4.2'den az olan 47 hastanın (% 66) PFS'si 31 ay, PFS değeri 4.2'den yüksek olan 27 (% 29.2) hastada 21 aydı ve istatistiksel olarak anlamlıydı (p; 0,010). Sonuç: Çalışmamızın sonuçları yüksek tedavi öncesi yüksek NLR'nin over kanseri hastalarında kötü prognoz ile ilişkili olduğunu göstermektedir.

Keywords

• over kanseri,nötrofil lenfosit oranı,prognoz

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