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ENDOMETRIAL ADENOCARCINOMA ARISING IN ATYPICAL POLYPOID ADENOMYOMA: A CASE REPORT

Year 2014, Volume: 17 Issue: 1, 0 - 0, 01.01.2014

Abstract

Atypical polypoid adenomyoma is an uncommon and benign tumor of the uterus. In some patients, however, APA has been found
to coexist with or to precede the development of an endometrioid adenocarcinoma similarly to complex endometrial hyperplasia.
Atypical polypoid adenomyoma affecting mainly women of child-bearing age and infertility is a common association. We present
one of the few youngest cases report. A 29-year-old woman presented with irregular, heavy menses, pelvic pain and uterine mass
located entirely in the lower uterine segment and cervical canal. Total abdominal hysterectomy was performed and based on
the morphological and histopathological findings a diagnosis of atypical polypoid adenomyoma with coexistent endometrial
adenocarcinoma was made. She has remained disease-free for over 22 months. Although rare, the diagnosis of atypical polypoid
adenomyoma should be considered in the differential diagnoses of endometrial adenocarcinoma, cervical adenocarcinoma and
the mass located in the lower uterine segment.

References

  • 1. Wong AY, Chan KS, Lau WL, Tang LC. Pregnancy outcome of a patient with atypical polypoid adenomyoma. Fertil Steril. 2007 Nov;88(5):1438.e7-9.
  • 2. Jakus S, Edmonds P, Dunton C, Holland G. Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. J Low Genit Tract Dis. 2002 Jan;6(1):33-8.
  • 3. Young RH, Treger T, Scully RE. Atypical polypoid adenomyoma of the uterus. A report of 27 cases. Am J Clin Pathol. 1986 Aug;86(2):139-45.
  • 4. Mazur MT: Atypical polypoid adenomyoma of the endometrium. Am J Surg Pathol 5:473-482, 1981
  • 5. Longacre TA, Chung MH, Rouse RV, et al: Atypical polypoid adenomyofi broma (atypical polypoid adenomyomas) of the uterus. Am J Surg Pathol 20:1-20, 1996
  • 6. Sugiyama T, Ota S, Nishida T, et al: Two cases of endometrial adenocarcinoma arising from atypical polypoid adenomyoma. Gynecol Oncol 71:141-144, 1998
  • 7. Heatley MK. Atypical polypoid adenomyoma: a systematic review of the English literature. Histopathology. 2006 Apr;48(5):609-10.
  • 8. Ota S, Catasus L, Matias-Guiu X, Bussaglia E, Lagarda H, Pons C, Muñoz J, Kamura T, Prat J. Molecular pathology of atypical polypoid adenomyoma of the uterus. Hum Pathol. 2003 Aug;34(8):784-8.

ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU

Year 2014, Volume: 17 Issue: 1, 0 - 0, 01.01.2014

Abstract

Atipik polipoid adenomyoma uterusun benign yapıda ve nadir görülen bir tümörüdür. Bununla birilikte bazı hastalarda atipik
polipoid adenomyoma ya endometrioid adenokarsinomu ile birliktelik gösterir yada kompleks endometriyal hiperplaziye benzer
şekilde bu kanserin gelişmesine öncülük eder. Atipik polipoid adenomyoma çoğunlukla doğurganlık yaşındaki kadınlarda görülür
ve infertilite öyküsü ile yakından ilişkilidir. Çalışmamızda şimdiye kadar bildirilen en genç olgulardan birisini sunmaktayız. 29 yaşında
bir kadın hasta düzensiz ve aşırı kanama, pelvik ağrı, alt uterin segment ve servikal kanala tamamıyla yerleşmiş uterus kaynaklı
bir kitle ile kliniğimize başvurdu. Total abdominal histerektomi yapılan hastada, morfolojik ve histopatolojik bulgulara dayanarak
endometrial adenokarsinomanın eşlik ettiği atipik polipoid adenomyoma tanısı konuldu. Hastamızın 22 aydan daha uzun bir
süreçde takiplerinde hastalık tekrarı görülmedi. Nadir görülmesine rağmen, endometriyum adenokarsinomu, serviks adenokarsinomu
veya alt uterin segment kaynaklı kitlelerin ayırıcı tanısında atipik polipoid adenomyoma tanısı akılda bulundurulmalıdır.

References

  • 1. Wong AY, Chan KS, Lau WL, Tang LC. Pregnancy outcome of a patient with atypical polypoid adenomyoma. Fertil Steril. 2007 Nov;88(5):1438.e7-9.
  • 2. Jakus S, Edmonds P, Dunton C, Holland G. Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. J Low Genit Tract Dis. 2002 Jan;6(1):33-8.
  • 3. Young RH, Treger T, Scully RE. Atypical polypoid adenomyoma of the uterus. A report of 27 cases. Am J Clin Pathol. 1986 Aug;86(2):139-45.
  • 4. Mazur MT: Atypical polypoid adenomyoma of the endometrium. Am J Surg Pathol 5:473-482, 1981
  • 5. Longacre TA, Chung MH, Rouse RV, et al: Atypical polypoid adenomyofi broma (atypical polypoid adenomyomas) of the uterus. Am J Surg Pathol 20:1-20, 1996
  • 6. Sugiyama T, Ota S, Nishida T, et al: Two cases of endometrial adenocarcinoma arising from atypical polypoid adenomyoma. Gynecol Oncol 71:141-144, 1998
  • 7. Heatley MK. Atypical polypoid adenomyoma: a systematic review of the English literature. Histopathology. 2006 Apr;48(5):609-10.
  • 8. Ota S, Catasus L, Matias-Guiu X, Bussaglia E, Lagarda H, Pons C, Muñoz J, Kamura T, Prat J. Molecular pathology of atypical polypoid adenomyoma of the uterus. Hum Pathol. 2003 Aug;34(8):784-8.
There are 8 citations in total.

Details

Other ID JA84HK74BY
Journal Section Case Report
Authors

Ülker Volkan This is me

Keleş Derya This is me

Ceyhun Numanoğlu This is me

Adnan Erim This is me

Nermin Gündüz This is me

Publication Date January 1, 2014
Submission Date January 1, 2014
Published in Issue Year 2014 Volume: 17 Issue: 1

Cite

APA Volkan, Ü., Derya, K., Numanoğlu, C., Erim, A., et al. (2014). ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU. Türk Jinekolojik Onkoloji Dergisi, 17(1).
AMA Volkan Ü, Derya K, Numanoğlu C, Erim A, Gündüz N. ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU. TRSGO Dergisi. January 2014;17(1).
Chicago Volkan, Ülker, Keleş Derya, Ceyhun Numanoğlu, Adnan Erim, and Nermin Gündüz. “ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU”. Türk Jinekolojik Onkoloji Dergisi 17, no. 1 (January 2014).
EndNote Volkan Ü, Derya K, Numanoğlu C, Erim A, Gündüz N (January 1, 2014) ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU. Türk Jinekolojik Onkoloji Dergisi 17 1
IEEE Ü. Volkan, K. Derya, C. Numanoğlu, A. Erim, and N. Gündüz, “ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU”, TRSGO Dergisi, vol. 17, no. 1, 2014.
ISNAD Volkan, Ülker et al. “ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU”. Türk Jinekolojik Onkoloji Dergisi 17/1 (January 2014).
JAMA Volkan Ü, Derya K, Numanoğlu C, Erim A, Gündüz N. ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU. TRSGO Dergisi. 2014;17.
MLA Volkan, Ülker et al. “ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU”. Türk Jinekolojik Onkoloji Dergisi, vol. 17, no. 1, 2014.
Vancouver Volkan Ü, Derya K, Numanoğlu C, Erim A, Gündüz N. ATİPİK POLİPOİD ADENOMYOMA VE BU TÜMÖRDEN KAYNAKLANAN ENDOMETRİAL ADENOKARSİNOMA: OLGU SUNUMU. TRSGO Dergisi. 2014;17(1).