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DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS

Year 2014, Volume: 17 Issue: 2, 0 - 0, 01.04.2014

Yavuz Salihoğlu Hamdullah Sözen Ahmet Cem İyibozkurt

Abstract

Amaç: Bu retrospektif çalışmanın amacı, kliniğimizde opere edilmiş düşük dereceli endometrial stromal sarkom olgularında lenfatik
yayılım deneyimimizi paylaşmak ve rekurrens şeklini araştırmaktır.
Hastalar ve Yöntem: Kliniğimizde Ağustos 2001 ile Kasım 2011 arasında düşük dereceli endometriyal stromal sarkom nedeniyle
opere edilmiş 14 olgu retrospektif olarak ele alındı. Yüm hastalara histerektomi yapıldı, ancak 6 hastaya pelvik ve/veya paraaortik
lenfadenektomi yapıldı (% 43). Üç hasta takip sürecinden ayrıldı. Ortalama takip süresi 51 ay idi.
Bulgular: 3 hastada lenfatik tutulum mevcuttu (%50). 11 takipli hastadan 2’sinde ekstrauterin tutulum saptandı (%18). İlk cerrahinin
suboptimal olmasından dolayı, 3 hastada (%21) ikinci kez operasyona gereksinim oldu.
Sonuç: Bu bulgular göstermektedir ki; düşük dereceli endometrial stromal sarkomlarda lenf nodu insidansı beklenenden daha
fazladır. Daha geniş lenf nodu örneklemeleri veya daha fazla hastada lenfadenektomi sonuçları ile daha anlamlı sonuca varılabilir.

Keywords

Endometriyal stromal sarkom lenf nodu metastazı

References

  • 1. Norris HJ Taylor HB. Mesendnymal tumors of uterus. A clinical and pathologis study of 53 endometrial stromal tumors. Cancer. 1966; 19: 755-766
  • 2. Chang KL, Crabtree GS, Lim-Tan SK. Primary uterine endometrial stromal neoplasms. A clinicopathology study of 117 cases. Am J Surg Pathol 1990; 14: 415-38
  • 3. Golf BA, Rice LW, Flelschhacker D, et al. Uterine leiomyosarcoma and endometrial stromal sarcoma: lymph node metastases and sites of recurrence. Gynecol Oncol. 1993; 50: 105-109
  • 4. Riopel J, Plante M, Renaud MC, et al. Lymph node metastases low-grade endometrial stromal sarcoma. Gynecol Oncol. 2005; 96: 402-406
  • 5. Rose PG, Piver MS, Tsukada Y, Lau T. Patterns of metastasis in uterine sarcoma. An Autopsy study. Cancer. 1989; 63: 635-8
  • 6. The National Cancer Institute. Available at: http//www. cancer.gov/cancertopics/pdq/treatement/Uterinesarcoma/ HealthProfessional. Accessed September 10, 2011.
  • 7. Leath CA 3rd, Huh WK, Hyde J Jr, et al. a multiinstitutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol. 2007; 105: 630-634
  • 8. El Husseiny G, Al Bareedy U, Mourad WA, Mohamed G, Shoukri M, Subhi J, et al. Prognostic factors and treatement modalities in uterine sarcoma. Am J Clin Oncol. 2002; 25: 256-60
  • 9. Golf BA, Rice LW, Flelschhacker D, Muntz HG, Falkanberry SS, Nikrui N, et al. Uterine leiomyosarcoma and endometrial stromal sarcoma: lymph node metastases and sites of recurrence. Gynecol Oncol. 1993; 50: 105-9
  • 10. Ayhan A, Tuncer ZS, Tanir M, Yuce K, Ayhan A. Uterine sarcoma, the Hacettepe Hospital experience of 88 consecutive patients. Eur J gynecol Oncol. 1997; 18: 146-8

LYMPH NODE METASTASES AND PATTERNS OF RECURRENCE IN LOW-GRADE ENDOMETRIAL STROMAL SARCOMA

Year 2014, Volume: 17 Issue: 2, 0 - 0, 01.04.2014

Yavuz Salihoğlu Hamdullah Sözen Ahmet Cem İyibozkurt

Abstract

Objective: The purpose of this retrospective study is to investigate recurrence patterns and review our experience on lmyphatic
dissemination in patients with low-grade endometrial stromal sarcoma.
Study design: A retrospective review yielded 14 patients with ESS (all of them low-grade) who underwent primary surgical resection
from August 2001 to November 2011. All patients underwent hysterectomy, whereas pelvic and/or paraaortic lymphadenectomy
were performed in 6 patients (43%). Three of these patients had lack of follow-up. Median follow-up time was 51 months.
Results: Lymphatic disease was noted in 3 patients (50%). Extrauterine recurrence was identified in 2 patients out of 11 full followup
patients (18%). As the primary surgery was suboptimal, 3 patients (21%) were underwent secondary staging surgery.
Conclusion: These findings suggest that the incidence of lymph node involvement in low-grade ESS is higher than expected.
More extensive sampling of lymph nodes or complete lymphadenectomy in a larger number of patients may allow a better
understanding of the frequency of lymph node involvement in low-grade ESS

Keywords

Endometrial stromal sarcoma lymph node metastases

References

  • 1. Norris HJ Taylor HB. Mesendnymal tumors of uterus. A clinical and pathologis study of 53 endometrial stromal tumors. Cancer. 1966; 19: 755-766
  • 2. Chang KL, Crabtree GS, Lim-Tan SK. Primary uterine endometrial stromal neoplasms. A clinicopathology study of 117 cases. Am J Surg Pathol 1990; 14: 415-38
  • 3. Golf BA, Rice LW, Flelschhacker D, et al. Uterine leiomyosarcoma and endometrial stromal sarcoma: lymph node metastases and sites of recurrence. Gynecol Oncol. 1993; 50: 105-109
  • 4. Riopel J, Plante M, Renaud MC, et al. Lymph node metastases low-grade endometrial stromal sarcoma. Gynecol Oncol. 2005; 96: 402-406
  • 5. Rose PG, Piver MS, Tsukada Y, Lau T. Patterns of metastasis in uterine sarcoma. An Autopsy study. Cancer. 1989; 63: 635-8
  • 6. The National Cancer Institute. Available at: http//www. cancer.gov/cancertopics/pdq/treatement/Uterinesarcoma/ HealthProfessional. Accessed September 10, 2011.
  • 7. Leath CA 3rd, Huh WK, Hyde J Jr, et al. a multiinstitutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol. 2007; 105: 630-634
  • 8. El Husseiny G, Al Bareedy U, Mourad WA, Mohamed G, Shoukri M, Subhi J, et al. Prognostic factors and treatement modalities in uterine sarcoma. Am J Clin Oncol. 2002; 25: 256-60
  • 9. Golf BA, Rice LW, Flelschhacker D, Muntz HG, Falkanberry SS, Nikrui N, et al. Uterine leiomyosarcoma and endometrial stromal sarcoma: lymph node metastases and sites of recurrence. Gynecol Oncol. 1993; 50: 105-9
  • 10. Ayhan A, Tuncer ZS, Tanir M, Yuce K, Ayhan A. Uterine sarcoma, the Hacettepe Hospital experience of 88 consecutive patients. Eur J gynecol Oncol. 1997; 18: 146-8
There are 10 citations in total.

Details

Other ID JA94ZR49BN
Journal Section Research Article
Authors

Yavuz Salihoğlu This is me

Hamdullah Sözen This is me

Ahmet Cem İyibozkurt This is me

Publication Date April 1, 2014
Submission Date April 1, 2014
Published in Issue Year 2014 Volume: 17 Issue: 2

Cite

APA Salihoğlu, Y., Sözen, H., & İyibozkurt, A. C. (2014). DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS. Türk Jinekolojik Onkoloji Dergisi, 17(2).
AMA Salihoğlu Y, Sözen H, İyibozkurt AC. DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS. TRSGO Dergisi. April 2014;17(2).
Chicago Salihoğlu, Yavuz, Hamdullah Sözen, and Ahmet Cem İyibozkurt. “DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS”. Türk Jinekolojik Onkoloji Dergisi 17, no. 2 (April 2014).
EndNote Salihoğlu Y, Sözen H, İyibozkurt AC (April 1, 2014) DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS. Türk Jinekolojik Onkoloji Dergisi 17 2
IEEE Y. Salihoğlu, H. Sözen, and A. C. İyibozkurt, “DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS”, TRSGO Dergisi, vol. 17, no. 2, 2014.
ISNAD Salihoğlu, Yavuz et al. “DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS”. Türk Jinekolojik Onkoloji Dergisi 17/2 (April 2014).
JAMA Salihoğlu Y, Sözen H, İyibozkurt AC. DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS. TRSGO Dergisi. 2014;17.
MLA Salihoğlu, Yavuz et al. “DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS”. Türk Jinekolojik Onkoloji Dergisi, vol. 17, no. 2, 2014.
Vancouver Salihoğlu Y, Sözen H, İyibozkurt AC. DÜŞÜK DERECELİ ENDOMETRİYAL STROMAL SARKOMLARDA LENF NODU METASTAZI VE REKÜRRENS. TRSGO Dergisi. 2014;17(2).