A New Myokin on Relationship Between Metabolic Disorders: Irisin

Abstract

Irisin is a myosin hormone that has been discovered in recent years and is thought to play an effective role in the prevention and treatment of many metabolic disorders, especially obesity. Since exercise is the most effective factor in stimulating irisin, it is intensively researched by sports scientists. It is believed that irisin can mediate the transformation of white adipose tissue, which is the main cause of obesity, into brown adipose tissue, thereby increasing heat production and energy expenditure and being effective in weight control. For this reason, irisin has become very popular in a short time. However, despite the promising results of obesity prevention in the studies after the discovery of the irisin, literatüre revealed contradictory results in an ongoing process. The exact similarity of irisin' amino acid sequence in rats and humans suggested that the results obtained in mice may also be valid in humans. However, obtaining relatively different results even in studies with similar designs have raised doubts about the promising approach to irisin. The most common acceptance of irisin is that it is affected only by aerobic exercises in an acute way. As a result, despite many ambiguities about irisin, it is thought that research on this hormone, which mediates the increase of energy expenditure as a common form in muscle and adipose tissue, will continue intensively in the near future.

Keywords

• Energy expenditure,brownish adipose tissue,cytokine,myokin,obesity

Metabolik Bozukluklara Karşı Egzersiz ile İlişkili Yeni Bir Miyokin: İrisin

Abstract

İrisin son yıllarda keşfedilen ve obezite başta olmak üzere birçok metabolik bozukluğun önlenmesi ve tedavi edilmesinde etkin rol oynadığı düşünülen miyokin özellikli bir hormondur. İrisinin uyarılmasındaki en etkili faktörün egzersiz olması sebebiyle spor bilimciler tarafından oldukça yoğun bir şekilde araştırılmaktadır. İrisinin, obezitenin asıl sebebi olan beyaz yağ dokusunun kahverengi yağ dokusuna dönüşmesinde aracılık edebileceği, böylece ısı üretimi ve enerji harcamasını artırarak kilo kontrolünde etkili olabileceği düşünülmektedir. Bu sebeple kısa sürede oldukça popüler olmuştur. Ancak, irisinin keşfinden sonraki çalışmalarda obezitenin önlenmesi yönünde oldukça umut verici sonuçlar raporlanmasına rağmen, devam eden süreçte oldukça çelişkili sonuçlar ortaya konmuştur. İrisin’in amino asit diziliminin farelerde ve insanlarda tam olarak benzerlik göstermesi, fareler üzerinde elde edilen sonuçların insanlarda da geçerli olabileceğini düşündürmüştür. Ancak benzer tasarıma sahip çalışmalarda bile nispeten farklı sonuçların elde edilmesi bu hormonun sahip olduğu umut verici yaklaşıma dair şüpheler oluşturmuştur. İrisin ile ilgili en yaygın kabul, aerobik egzersizden ve sadece akut olarak etkilendiği yönündedir. Sonuç olarak, irisin ile ilgili birçok belirsizliğe rağmen kas ve yağ dokusunda ortak bir form olarak enerji harcamasının artırılmasına aracılık eden bu hormonla ilgili araştırmaların yakın gelecekte yoğun bir şekilde devam edeceği düşünülmektedir.

Keywords

• Enerji harcaması,Kahveringi yağ dokusu,Sitokin,Miyokin,Obezite

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