Are obese rats influenced by GLP1 and IR through aerobic exercise? A case study

Year 2016, Volume: 18 Issue: 2, 1 - 7, 31.08.2016

Ali Sayyah Hamid Mohebbı Hamid Arazı Abbas Baharı

Abstract

The
present study aimed to consider the influence of aerobic exercise intensity on
GLP-1and IR in obese rats. Glucagon-like peptide-1 (GLP-1) is characterized as incretion
hormones secreted from the intestine upon ingestion of food to maximize insulin
secretion, regulate blood sugar and enhance insulin resistance (IR). It was an
in vitro study. The study subjects were thirty-two male Wistar rats which were
divided into 4 groups: three levels of aerobic training intensity (high,
moderate and low intensity) and one control group. Following 8 weeks of
different intensity of aerobic trainings, the researchers calculated plasma
concentration of glucose, insulin, HOMA-IR and GLP-1. We applied dependent
t-test and Analysis of variance (ANOVA) to test the research hypotheses. Body
weight, BMI, insulin, blood glucose and HOMA-IR in high,
moderate and low intensity of aerobic training were noticed to be significantly
lower than in the control group (P=0.001) following  an eight-week intervention. However, moderate
and high intensity of aerobic training compared with low intensity
significantly showed a decrease in insulin, blood glucose, HOMA-IR, and GLP-1.
The findings revealed that moderate and high intensity of aerobic training
results in GLP-1 secretion impairment, thus its improvement can cause a
reduction in insulin resistance and blood glucose regulation.

Keywords

Aerobic exercise, glucagon-like peptide-1, swimming exercise

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