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The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students

Year 2017, Volume: 19 Issue: 1, 50 - 53, 30.04.2017

Abstract

This study aimed to determine the
effect of regular exercise and vitamin C on hs-cTnT and TNF-α levels in obese
boys Students. In this regard, 28 Students aged 10-13 years, targeted sampling
and available, were randomly divided into control, exercise, supplementation,
exercise + supplement. The training protocol for group exercise and submaximal
aerobic exercise + supplement

includes eight weeks of growing at 50 to 70 percent of maximum heart rate, core
exercise 30 to 45 minutes per session, 3 sessions per week. Also, subjects in
the exercise group and exercise + supplement tablets of vitamin C (500 mg)
after taking food, ate every other day for 8 weeks. Blood samples were
collected after 12 hours of fasting in pre-test and post-test (48 hours after
the last exercise). Serum levels of hs-cTnT and TNF-α by
Electro-Chemiluminescence and ELISA (respectively) were measured. The results
showed that 8 weeks of aerobic exercise, vitamin C and combination of the above
interventions have an impact on hs-cTnT levels in obese boy’s students, but
TNF-α levels decreased significantly. Furthermore, the effect on the reduction
of TNF-α combined intervention of vitamin C was significantly higher. Therefore
the use of non-pharmacological methods, exercise, vitamin C and combination of
the above interventions may lead to a reduction of inflammation in obese boy’s
students.

References

  • Arslan N, Erdur B, Aydin A. Hormones and cytokines in childhood obesity. Indian Pediatr, 2010; 47(10): 829-39.
  • Azizi M, Rozmajo S, Rajabi H, Hedayati M, Ahmadi P. The effect of vitamin-mineral supplementation on oxidative stress and answers IL-6 and TNF-α exercising session in a heavy swimming in the girls elite swimmers. Journal of Endocrinology and Metabolism Iran, 2011; 4(12): 409-417.
  • Brown W, Williams L, Ford JH, Ball K, Dobson AJ. Identifying the energy gap: magnitude and determinants of five year weight gain in mid-age women. Obes Res, 2005; 13(8): 1431-1441.
  • Fruhbeck G. The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents, 2004; 2: 197–208.
  • Fu F, Nie J, Tong TK. Serum cardiac troponin T in adolescent runners: effects of exercise intensity and duration. Int J Sports Med, 2009; 30(3): 168-172.
  • Jason E, Lang MD. Obesity and asthma in children: current and future therapeutic options. Paediatr Drugs, 2014; 16(3): 179-188.
  • Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy, 2013; 43(7): 775-784.
  • Molnar D, Decsi T, Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. Int J Obes Relat Metab Disord, 2004; 28: 1197-1202.
  • Nair MP, Mahajan S, Reynolds JS, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. The flavonoid quercetin inhibits proinflammatory cytokine (Tumor Necrosis Factor Alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system. Clin Vaccine Immunol, 2006; 13(3): 319-328.
  • Pudel V, Ellrott T. Adipositasein gesellschaftspolitisches Problem? Chirurg, 2005; 76: 639-646.
  • Rodriguez A, Catalan V, Gomez Ambrosi J, Fruhbeck G. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des, 2007; 13: 2169-75.
  • Siervo M, Ruggiero D, Sorice R, Nutile T, AversanoM, Iafusco M, Vtrano F, Wells JC, Stephan BC, Ciullo M. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition, 2012; 28(3): 262-6.
  • Tayyebi-Khosroshahi H, Houshyar J, Dehgan-Hesari R, Alikhah H, Vatankhah AM, Safaeian AR. Effect of treatment with omega-3 fatty acids on C-reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Saudi J Kidney Dis Transpl, 2012; 23(3): 500-506.
  • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrrante AW. Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 2003; 112(12): 1796–1708.
Year 2017, Volume: 19 Issue: 1, 50 - 53, 30.04.2017

Abstract

References

  • Arslan N, Erdur B, Aydin A. Hormones and cytokines in childhood obesity. Indian Pediatr, 2010; 47(10): 829-39.
  • Azizi M, Rozmajo S, Rajabi H, Hedayati M, Ahmadi P. The effect of vitamin-mineral supplementation on oxidative stress and answers IL-6 and TNF-α exercising session in a heavy swimming in the girls elite swimmers. Journal of Endocrinology and Metabolism Iran, 2011; 4(12): 409-417.
  • Brown W, Williams L, Ford JH, Ball K, Dobson AJ. Identifying the energy gap: magnitude and determinants of five year weight gain in mid-age women. Obes Res, 2005; 13(8): 1431-1441.
  • Fruhbeck G. The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents, 2004; 2: 197–208.
  • Fu F, Nie J, Tong TK. Serum cardiac troponin T in adolescent runners: effects of exercise intensity and duration. Int J Sports Med, 2009; 30(3): 168-172.
  • Jason E, Lang MD. Obesity and asthma in children: current and future therapeutic options. Paediatr Drugs, 2014; 16(3): 179-188.
  • Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy, 2013; 43(7): 775-784.
  • Molnar D, Decsi T, Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. Int J Obes Relat Metab Disord, 2004; 28: 1197-1202.
  • Nair MP, Mahajan S, Reynolds JS, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. The flavonoid quercetin inhibits proinflammatory cytokine (Tumor Necrosis Factor Alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system. Clin Vaccine Immunol, 2006; 13(3): 319-328.
  • Pudel V, Ellrott T. Adipositasein gesellschaftspolitisches Problem? Chirurg, 2005; 76: 639-646.
  • Rodriguez A, Catalan V, Gomez Ambrosi J, Fruhbeck G. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des, 2007; 13: 2169-75.
  • Siervo M, Ruggiero D, Sorice R, Nutile T, AversanoM, Iafusco M, Vtrano F, Wells JC, Stephan BC, Ciullo M. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition, 2012; 28(3): 262-6.
  • Tayyebi-Khosroshahi H, Houshyar J, Dehgan-Hesari R, Alikhah H, Vatankhah AM, Safaeian AR. Effect of treatment with omega-3 fatty acids on C-reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Saudi J Kidney Dis Transpl, 2012; 23(3): 500-506.
  • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrrante AW. Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 2003; 112(12): 1796–1708.
There are 14 citations in total.

Details

Journal Section Articles
Authors

Mohammadbagher Forghani Ozrudı

Javad Alızade This is me

Aliakbar Raıespour This is me

Publication Date April 30, 2017
Acceptance Date May 10, 2017
Published in Issue Year 2017 Volume: 19 Issue: 1

Cite

APA Ozrudı, M. F., Alızade, J., & Raıespour, A. (2017). The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students. Turkish Journal of Sport and Exercise, 19(1), 50-53.
AMA Ozrudı MF, Alızade J, Raıespour A. The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students. Turk J Sport Exe. April 2017;19(1):50-53.
Chicago Ozrudı, Mohammadbagher Forghani, Javad Alızade, and Aliakbar Raıespour. “The Effect of Regular Exercise and Vitamin C on Hs-cTnT& TNF-α Levels in Obese Boys Students”. Turkish Journal of Sport and Exercise 19, no. 1 (April 2017): 50-53.
EndNote Ozrudı MF, Alızade J, Raıespour A (April 1, 2017) The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students. Turkish Journal of Sport and Exercise 19 1 50–53.
IEEE M. F. Ozrudı, J. Alızade, and A. Raıespour, “The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students”, Turk J Sport Exe, vol. 19, no. 1, pp. 50–53, 2017.
ISNAD Ozrudı, Mohammadbagher Forghani et al. “The Effect of Regular Exercise and Vitamin C on Hs-cTnT& TNF-α Levels in Obese Boys Students”. Turkish Journal of Sport and Exercise 19/1 (April 2017), 50-53.
JAMA Ozrudı MF, Alızade J, Raıespour A. The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students. Turk J Sport Exe. 2017;19:50–53.
MLA Ozrudı, Mohammadbagher Forghani et al. “The Effect of Regular Exercise and Vitamin C on Hs-cTnT& TNF-α Levels in Obese Boys Students”. Turkish Journal of Sport and Exercise, vol. 19, no. 1, 2017, pp. 50-53.
Vancouver Ozrudı MF, Alızade J, Raıespour A. The effect of regular exercise and vitamin C on hs-cTnT& TNF-α levels in obese boys students. Turk J Sport Exe. 2017;19(1):50-3.

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