The role of exercıse ın reducıng the sıde effects of antıpsıcotıcs used ın the treatment of bıpolar dısorders

Year 2019, Volume: 21 Issue: 1, 96 - 109, 30.04.2019

Hatice Toy , ERKUT Tutkun , ITIR Tarı Cömert

https://doi.org/10.15314/tsed.542914

Abstract

ABSTRACT

The study is a systematic evaluation of quantitative studies showing the relationship between drug use and physical activity in investigating the side effects of antipsychotics used in patients who have bipolar disorder.

Bipolar disorder is usually treated with medicine and the side effects of the drugs which are used to increase the body mass index of patients and this causes obesity. This study mainly aims to examine the role of exercise in reducing the side effects of antipsychotics which are used by individuals who have bipolar disorder with using the high-level evidence which was acquired from published systematic reviews and meta-analyzes.

Most antipsychotics cause weight gain; olanzapine and clozapine are seen as the antipsychotics which have highest risk. In the first period after taking antipsychotics, the weight is increasing rapidly, and patients continue to gain weight in the long term. One of the best strategies to prevent this situation is to adapt antipsychotics according to individual needs and to check over weight and other metabolic parameters closely.

The researches which were done and current information in the last 10 years were included in the study. Recent studies have shown that in the patients who have bipolar disorder, physical activity programs can play a significant role in supporting of mental and physical health. We hope that adding exercise to treatment plans for individuals with bipolar disorder may provide side benefits and be guidance for clinical practice, policy and future research.

Keywords

Bipolar disorder, Antipsychotics, Obesity, Exercise

References

• REFERENCES
• Ak, M. Sezlev, D. Sutcigil, L. Akarsu, S. Ozgen, F. Yanik, T. (2013). The investigation of leptin and hypothalamic neuropeptides role in first attack psychotic male patients: olanzapine monotherapy. Psychoneuroendocrinology. 38(3):341–347. Doi:10.1016/j.psyneuen. 2012.06.012.Allison, D.B., Mentore, J.L., Heo, M., Chandler, L. P., Cappelleri, J. C., Infante, M. C. & Weiden, P. J. (1999). Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 156(11):1686–1696. Doi:10.1176/ajp.156.11.1686
• Alsuwaidan, M.T., Kucyi, A., Law, C.W.Y. & Mcintyre, R.S. (2009). Exercise and bipolar disorder: a review of neurobiological mediators. Neuromolecular Med. 11, 328–336. Doi:10.1007/s12017-009-8079-9.Bak, M., Fransen, A., Janssen, J., van Os, J., Drukker, M. (2014). Almost all antipsychot¬ics result in weight gain: a meta-analysis. PLoS One. 9(4):e94112. Doi: 10.1371/journal.pone.0094112Bressert, S. (2019). Introduction to Bipolar Disorder. Psych Central. (Retrieved on February 27, 2019), from https://psychcentral.com/disorders/bipolar/introduction-to-bipolar-disorder/Butler, M., Urosevic, S., Desai, P., Sponheim, S.R., Popp, J., Nelson, V. A., Thao, V., Sunderlin, B. (2018). Treatment for Bipolar Disorder in Adults: A Systematic Review.https://www.ncbi.nlm.nih.gov/books/NBK532183/pdf/Bookshelf_NBK532183.pdfCairney, J., Veldhuizen, S., Faulkner, G., Schaffer, A. & Rodriguez, M.C. (2009). Bipolar disorder and leisure-time physical activity: results from a national survey of Canadians. Ment. Health Phys. Act. 2, 65–70. Doi:10.1016/j.mhpa.2009.09.003Carek, P. J., Laibstain, S. E., Carek S. M. (2011). Exercise for the treatment of depression and anxiety. Int. J. Psychiatry Med. 41, 15–28. Doi:10.2190/PM.41.1.c Cooper, S.J., Reynolds, G.P., Barnes, T., England, E., Haddad, P.M., Heald, A., Holt, R., Lingford-Hughes, A., Osborn, D., McGowan, O., Patel, M..X., Paton, C., Reid, P., Shiers, D., Smith, J. (2016). BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment. J Psychopharmacol. 30(8):717–748. Doi: 10.1177/ 0269881116645254. Creta, E., Fabbri, C., Serretti, A. (2015). Genetics of second-generation antipsychotic and mood stabilizer-induced weight gain in bipolar disorder: common and specific effects of key regulators of fat-mass homoeostasis genes. Pharmacogenet Genomics. 2015 Jul;25(7): 354-62. Doi: 10.1097/FPC.0000000000000144.Crump, C., Sundquist, K., Winkleby, M.A., Sundquist, J. (2013). Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. JAMA Psychiatry 70, 931–939. Doi:10.1001/jamapsychiatry.2013.1394 Daumit, G. L., Dickerson, F. B., Wang, N. Y., Dalcin, A., Jerome, G. J., Anderson, C. A. M, Young, D. R., Frick, K. D., Yu, A., Gennusa, J. V., Oefinger, M., Crum, R. M., Charleston, J., Casagrande, S. S., Eliseo Guallar, E., Goldberg, R. W., Campbell, L. M., Lawrence J. Appel, L. J. (2013). A behavioral weight-loss intervention in persons with serious mental illness. N. Engl. J. Med. 368, 1594–1602. Doi:10.1056/NEJMoa1214530De Hert, M., Detraux, J., Van Winkel, R., Yu, W., Correll, C.U. (2011). Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nat Rev Endocrinol. 8(2):114–126. Doi: 10.1038/nrendo.2011.156.De Hert, M., Yu, W., Detraux, J., Sweers, K., Van Winkel, R., Correll, C.U. (2012). Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis. CNS Drugs. 26(9):733–759. Doi: 10.2165/11634500-000000000-00000.Detke, H.C., DelBello, M.P., Landry, J., Hoffmann, V.P., Heinloth, A., Dittman, R.W. (2016). A 52-Week Study of Olanzapine with a Randomized Behavioral Weight Counseling Intervention in Adolescents with Schizophrenia or Bipolar I Disorder. J Child Adolesc Psychopharmacol. 2016 Dec;26(10):922-934. Epub 2016 Sep 27. Doi:10.1089 /cap. 2016.0010Dodd, S., Brnabic, A. J., Berk, L., Fitzgerald, P. B., De Castella, A. R., Filia, S., Filia, K., Kelin, K., Smith, M., Montgomery, W., Kulkarni, J., Berk, M. (2010). A prospective study of the impact of smoking on outcomes in bipolar and schizoaffective disorder. Compr. Psychiatry 51, 504–509. Doi:10.1016/ j.comppsych. 2009.12.001 Dome, P., Gonda, X., Rihmer, Z. (2012). Effects of smoking on health outcomes in bipolar disorder with a special focus on suicidal behavior. Neuropsychiatry 2, 429–441 Doi: 10.2217/npy.12.51Fang, F., Wang, Z., Wu, R., Calabrese, J.R., Gao, K. (2017). Is there a 'weight neutral' second-generation antipsychotic for bipolar disorder?. Expert Rev Neurother. 2017 Apr; 17(4): 407-418. Doi: 10.1080/14737175.2016.1276284. Fleischhacker, W.W., Heikkinen, M.E., Olie, J. P., Landsberg, W., Dewaele, P., McQuade, R. D., Loze, J. Y., Hennicken, D., Kerselaers, W. (2010). Effects of adjunc-tive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. Int J Neuro-psychopharmacol. 13(8): 1115–1125. Doi: 10.1017/S1461145710000490.Goldberg, J. (2017). Antipsychotic Medication for Bipolar Disorder; Side Effects of Antipsychotic Drugs. WebMD Medical Reference. https://www.webmd.com/bipolar-disorder/ guide/ antipsychotic-medication#1-2.Gonçalves, P., Araujo, J. R., Martel, F. (2015). Antipsychotics-induced metabolic alterations: focus on adipose tissue and molecular mechanisms. Eur Neuropsychopharmacol. 25(1): 1–16. Doi: 10.1016/j.euroneuro.2014.11.008.Grohol, J. (2018). Atypical Antipsychotics for Bipolar Disorder. Psych Central. https://psychcentral.com/lib/atypical-antipsychotics-for-bipolar-disorder/.Henderson, D. C., Vincenzi, B., Andrea, N. V., Ulloa, M., Copeland, P. M. (2015). Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses. Lancet Psychiatry. 2(5):452–464. Doi: 10.1016/S2215-0366(15)00115-7.Janney, C. A., Fagiolini, A., Swartz, H. A., Jakicic, J. M., Holleman, R. G., Richardson, C. R. (2014). Are adults with bipolar disorder active? Objectively measured physical activity and sedentary behavior using accelerometry. J. Affect. Disord. 152–154, 498–504. Doi: 10.1016/j.jad.2013.09.009Kilbourne, A. M., Morden, N. E., Austin, K., Ilgen, M., Mccarthy, J. F., Dalack, G., Blow, F. C. (2009). Excess heart-disease-related mortality in a national study of patients with mental disorders: identifying modifiable risk factors. Gen. Hosp. Psychiatry 31, 555–563. Doi:10.1016/j.genhosppsych.2009.07.008 Lasikiewicz, N., Myrissa, K., Hoyland, A., Lawton, C.L. (2014). Psychological benefits of weight loss following behavioural and/or dietary weight loss interventions. A systematic research review. Appetite. 72: 123–137. Doi: 10.1016/j.appet.2013.09.017Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Orey, D., Richter, F., Samara, M., Barbui, C., Engel, R. R., Geddes, J. R., Kissling, W., Stapf, M. P., Lässig, B., Salanti, G., Davis, J. M. (2013). Comparative efficacy and toler-ability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 382(9896):951–962. Doi: 10.1016/S0140-6736(13)60733-3.Lu, M. L., Wang, T. N., Lin, T. Y., Shao, W. C., Chang, S. H., Chou, J. Y., Ho, Y. F., Liao, Y. T., Chen, V.C. (2015). Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin. Prog Neuropsychopharmacol Biol Psychiatry. 58:47–50. Doi: 10.1016/j.pnpbp.2014.12.001.Maletic, V. (2017). Updates to the diagnosis and management of bipolar depression: Have we been going about this all wrong?. Presented at Elevate by Psych Congress 2017; March 3, 2017; San Francisco, CA. https://www.psychcongress.com/article/bipolar-disorder-deadly-disease-dangerous-comorbiditiesMelo, M., Daher, E., Albuquerque, S. & De Bruin, V. (2016). Exercise in bipolar patients: A systematic review. Journal of Affective Disorders. Doi:10.1016/j.jad.2016.03.004Merikangas, K. R., Swendsen, J., Hickie I. B., Cui, L., Shou, H., Merikangas, A. K., Zhang, J., Lamers, F., Crainiceanu, C., Volkow, N. D., Zipunnikov, V. (2018). Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder. JAMA Psychiatry. 2018: 76(2):190-198. Doi:10.1001/jamapsychiatry.2018.3546. Meyer, J. M., Ng-Mak, D. S., Chuang, C. C., Rajagopalan, K., Loebel, A. (2017). Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records. Ann Gen Psychiatry. 2017 Oct 17;16:36. Doi: 10.1186/s 12991-017-0159-x. Moylan, S., Eyre, H. A., Maes, M., Baune, B. T., Jacka, F. N., Berk, M. (2013). Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours. Neurosci. Biobehav. Rev. 37, 573–584. Doi:10.1016/j.neubiorev.2013.02.003Olfson, M., Gerhard, T., Huang, C., Crystal, S., Stroup, T.S. (2015). Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry. 72(12):1172–1181. Doi: 10.1001/jamapsychiatry.2015.1737.Ostacher, M., Ng-Mak, D., Patel, P., Ntais, D., Schlueter, M., Loebel, A. (2018). Lurasidone compared to other atypical antipsychotic monotherapies for bipolar depression: A systematic review and network meta-analysis. World J Biol Psychiatry. 19(8):586-601. Doi: 10.1080/15622975.2017.1285050. Proudfoot, J., Whitton, A., Parker, G., Doran, J., Manicavasagar, V., Delmas, K. (2012). Triggers of mania and depression in young adults with bipolar disorder. J. Affect. Disord. 143, 196–202. Doi:10.1016/j.jad.2012.05.052 Rado, J. & Cavanaugh, S. (2016). A Naturalistic Randomized Placebo-Controlled Trial of Extended-Release Metformin to Prevent Weight Gain Associated With Olanzapine in a US Community-Dwelling Population. J Clin Psychopharmacol. 2016 Apr;36(2):163-8. Doi: 10.1097/JCP.0000000000000469.Roshanaei-Moghaddam, B. & Katon, W. (2009). Premature mortality from general medical illnesses among persons with bipolar disorder: a review. Psychiatr. Serv. 60, 147–156. Doi:10.1176/ps.2009.60.2.147Rubio-Terrés, C., Rubio-Rodríguez, D., Baca-Baldomero, E. (2014). Cost analysis of the adverse reactions of bipolar disorder treatment with aripiprazole and olanzapine in Spain. Actas Esp Psiquiatr. 2014 Sep-Oct;42(5):242-9. Epub 2014 Sep 1.Rummel-Kluge, C., Komossa, K., Schwarz, S., Hunger, H., Schmid, F., Lobos, C. A., Kissling, W., Davis, J. M., Leucht, S. (2010). Head-to-head com-parisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res. 123(2–3):225–233. Doi: 10.1016/j.schres.2010.07.012Stubbs, B., Vancampfort, D., Hallgren, M., Hallgren, M., Firth, J., Veronese, N., Solmi, M., Brand, S., Cordes, J., Malchow, B., Gerber, M., Schmitt, A., Correll, C. U., De Hert, M., Gaughran, F., Schneider, F., Kinnafick, F., Falkai, P., Möller, H. J., Kahl, K. G. (2018). EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH) European Psychiatry. pp. 124–144. http://dx.doi.org/10.1016/j.eurpsy.2018.07.004Suto, M., Murray, G., Hale, S., Amari, E., Michalak, E. E. (2010). What works for people with bipolar disorder? Tips from the experts. J. Affect. Disord. 124, 76–84. Doi:10.1016/j.jad.2009.11.004 Sylvia, L. G., Ametrano, R. M., Nierenberg, A. A. (2010). Exercise treatment for bipolar disorder: potential mechanisms of action mediated through increased neurogenesis and decreased allostatic load. Psychother. Psychosom.79, 87–96. Doi:10.1159/000270916 Sylvia, L. G., Nierenberg, A. A., Stange, J. P., Peckham, A. D., Deckersbach, T. (2011). Development of an integrated psychosocial treatment to address the medical burden associated with bipolar disorder. J. Psychiatr. Pract. 17, 224–232. Doi: 10. 1097/01.pra.0000398419.82362.32 Sylvia, L. G., Friedman, E. S., Kocsis, J. H., Bernstein, E. E., Brody, B. D., Kinrys, G., Kemp, D. E., Shelton, R. C., McElroy, S. L., Bobo, W. V., Kamali, M., McInnis, M. G., Tohen, M., Bowden, C. L., Ketter, T. A., Deckersbach, T., Calabrese, J. R., Thase, M. E., Reilly-Harrington, N. A., Singh, V., Rabideau, D. J., Nierenberg, A. A. (2013a). Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder. J. Affect. Disord. 151, 722–727. Doi:10.1016/j.jad.2013.07.031 Sylvia, L. G., Salcedo, S., Bernstein, E. E., Baek, J. H., Nierenberg, A. A., Deckersbach, T. (2013b). Nutrition, Exercise, and Wellness Treatment in bipolar disorder: proof of concept for a consolidated intervention. Int. J. Bipolar Disord. 1, 24. Doi:10.1186/2194-7511-1-24 Talaeı, A., Farıdhosseını, F., Kazemı, H., Fayyazı Bordbar, M.R., Rezaeı Ardanı, A. (2016). Effect of Topiramate on Drug Associated Weight Gain of Patients with Schizophrenia and Bipolar I Disorders: A Dose Ranging Randomized Trial, Turk Psikiyatri Derg. 2016 Summer; 27(2):0. https://www.ncbi.nlm.nih.gov/pubmed/27370059Vancampfort, D., Correll, C., Probst, M., Sienaert, P., Wyckaert, S., De Herdt, A., Knapen, J., De Wachter, D. & De Hert, M. (2013). A review of physical activity correlates in patients with bipolar disorder. Journal of Affective Disorders. Doi: 10. 1016/ j.jad. 2012.07.020Vancampfort, D. & Goldstein, B.I. (2018). Bipolar Disorder and Physical Activity. Exercise-Based Interventions for Mental Illness. Physical Activity as Part of Clinical Treatment. 1 st Edition; Chapter 3. pp. 53-63.Van Citters, A. D., Pratt, S. I., Jue, K., Williams, G., Miller, P. T., Xie, H., Bartels, S. J. (2010). A pilot evaluation of the in SHAPE individualized health promotion intervention for adults with mental illness. Community Ment. Health J. 46, 540–552. Doi:10.1007/s10597-009-9272-x Vieta, E. & Montes, J. M. (2018). A Review of Asenapine in the Treatment of Bipolar Disorder. Clin Drug Investig. 38(2):87-99. Doi: 10.1007/s40261-017-0592-2.Wildes, J., Marcus, M., Fagiolini, A. (2006). Obesity in patients with bipolar disorder: A biopsychosocial-behavioral model. Journal of Clinical Psychiatry. 67(6):904-915. https://www.psychiatrist.com/jcp/article/Pages/2006/v67n06/v67n0607.aspxWright, K., Armstrong, T., Taylor, A., Dean, S. (2012). “It’s a double edged sword”: a qualitative analysis of the experiences of exercise amongst people with Bipolar Disorder. J. Affect. Disord. 136, 634–642. Doi:10.1016/j.jad.2011.10.017 Zhang, J.P., Lencz, T., Zhang, R.X., Nitta, M., Maayan, L., John, M., Robinson, D. G., Fleischhacker, W. W., Kahn, R. S., Ophoff, R. A., Kane, J. M., Malhotra, A., K., Correll, C. U. (2016). Pharmacogenetic associations of antipsychotic drug-related weight gain: a systematic review and meta-analysis. Schizophr Bull. 42(6):1418–1437. Doi: 10.1093/schbul/sbw058.