Determination of HIF1Ars11549465 Polymorphism in Elite Skiers

Year 2019, Volume: 21 Issue: 2, 328 - 331, 15.09.2019

Ömer Kaynar , Fatih Bilici , Korkut Ulucan , Canan Sercan

https://doi.org/10.15314/tsed.544566

Cited By: 1

Abstract

ABSTRACT

Studies in sport genetics have increased
nowadays and the identification of genotype and allelic distributions of
candidate genes in different athletes has provided important information to
sports scientists. One of the candidate genes studied in sports genetics is the
hypoxia-inducible factor 1-alpha (HIF1A) gene, which is associated with the
endurance phenotype. In our study, we aimed to determine the genotypic and
allelic distribution of HIF1A
rs11549465 polymorphism in Turkish Elite Ski Runners. 34 (23 male, 11 female)
athletes were included in the study, and 1 cc of blood samples taken for
routine analysis after the approval of the ethics committee was used for DNA
isolation. The commercial kit was used for DNA isolation and genotyping was
performed by Real-time PCR method. The number and percentage of CC, CT and TT
genotypes of the HIF1A rs11549465 polymorphism were 24 (72.72%), 8 (24.24%) and
1 (3.03), respectively. In male skiers CC, CT and TT genotype numbers and
percentages were determined as 17 (55.51%), 4 (12.12%) and 1 (3.03%)
respectively. In female, CC and TT genotypes were determined as 7 (21.21%)
and 4 (12.12%). We detected no
TT genotype in female athletes. When we look at allel numbers, C allele was
determined as 56 (84.84%) and T allele was determined as 10 (15.15%). This is
the first study on HIF1A rs11549465
polymorphism on Turkish elite ski runners. The higher prevalence of CC genotype
and C allele in the athlete group is similar to the previous studies on
different groups of athletes. We believe that this study will be an important
reference for further studies.

Keywords

Sport genetics, cross-country, athletic performance

References

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