The Effects of Trenbolone Supplementation on The Extremity Bones in Running Rats

Year 2019, Volume: 21 Issue: 2, 366 - 371, 15.09.2019

Ali Sarı , Sefa Lök

https://doi.org/10.15314/tsed.555015

Cited By: 1

Abstract

ABSTRACT

Anabolic
steroids are testosterone derivatives through which anabolic effects are
maintained and androgenic effects are minimized. The use of ergogenic agents is
increasing among athletes for doping in order to increase physical performance
and change external image. The objective of this study was to determine effects
of trenbolone supplement administered on running rats for 4 weeks on extremity
bones. The study was conducted with 28 male Wistar rats aged 28 days with a
mean weight of 61,80 g supplied from the Selcuk University Experimental Medical
Research and Application Center. The rate were divided into 4 groups as C
(Controls), E (Exercise), T (Trenbolone), and TE (trenbolone + Exercise). The
trial period lasted 4 weeks. Supply, care, feeding, and experimental
applications of rats were performed in the Selcuk University Experimental
Medical Research and Application Center. Anterior and posterior extremities’
bones were dissected and exposed, and the humerus and femur bones exposed were
dried. Length, corpus thickness, cortex thickness, and medulla diameter points
were determined and the necessary measures were taken. The results are
expressed as mean ± SD. ANOVA and Duncan tests were used for the comparison of
data. p<0.05 values were considered statistically significant. The mean
femoral length was found as 31.31 ± 0.69 in the rats in Group T, 31.46±0.72 in
Group E, 31.51±0.58 in Group TE, and 31.48 ± 0.71 in Group C (controls).
Examining the mean femoral lengths of Groups T, E, TE and C; the mean femoral
length in Group T was numerically higher than that of the Groups E, TE and C,
although the difference was not statistically significant (F:0.112; p:0.637).
The mean humerus length was found as 24.93 ± 0.59 in the rats in Group T, 24.96±0.68
in Group E, 25.33±0.81 in Group TE, and 25.29±0.77 in Group C (controls).
Examining the mean humerus lengths of Groups T, E, TE and C; the mean humerus
length in Group T was numerically higher than that of the Groups E, TE and C,
although the difference was not statistically significant (F:0.608; p:0.355).
We found that the mean values of corpus and cortex thickness, and medullary
diameters were similar in the Groups T, E, TE, and C, and the differences were
not statistically significant (p>0.05). Results of
this study indicate that trenbolone supplement may lead to early epiphyseal
closure in femur and humerus bones of rats, ceasing the increase in their
length. We believe that the results obtained from this trenbolone trial will
provide important data to the studies that will be conducted on anabolic
androgenic steroids.  

 

Key
words: Anabolic Androgenic Steroid, Trenbolone, Rat, Femur, Humerus

Keywords

Anabolic Androgenic Steroid, Trenbolone, Rat

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