The Effects of Methenolone Enanthate Supplement with Exercise on Rats’ Bones

Year 2019, Volume: 21 Issue: 2, 276 - 280, 15.09.2019

Mehmet Özdemir Sefa Lök

https://doi.org/10.15314/tsed.555433

Cited By: 2

Abstract

Abstract

It is known that anabolic steroids are used by athletes to
increase their performance and cause many health problems. This study aims to
analyze the effects of methenolone enanthate supplement with exercise on rats’
bones.

The study was conducted with 28 28-day-old Wistar male rats
obtained from the Chair of the Experimental Medicine Research and Application Center of Selcuk
University. The rats were allocated into four groups: C (control, n:6), E
(exercise, n:7), M (methenolone enanthate, n:7) and ME (methenolone
enanthate+exercise, n:8). The required doses were arranged weekly depending on
the rats’ live weight for the groups given methenolone enanthate. The rats’
front and back extremity bones were dissected, and the humerus and femur bones
were dried. Each bone’s length, corpus thickness, cortex thickness and
medullary diameter points were determined. The results were presented as
mean±SD. ANOVA and Duncan's test were used for inter-group comparison of the
data. The threshold for statistical significance was p<0.05. The femur
length was 32.46±0.29 in the C group, 32.60±0.64 in the E group, 31.37±0.50 in
the ME group and 31.67±0.52 in the M group. The humerus length was 26.42±0.28
in the C group,26.23±0.59 in the E group, 25.31±0.40 in the ME group and
25.35±0.45 in the M group. The femur and humerus length was statistically
significantly shorter in the groups that received methenolone enanthate
supplement (M and ME) than that of the other two groups (p<0.05). No
statistically significant difference was found between the C, E, M and ME
groups in terms of the cortex and corpus thickness and medullary diameter of
their femur and humerus bones (p>0.05). It was concluded based on the study
results that methenolone enanthate supplement causes early epiphyseal closure
in rats’ femur and humerus bones and stops the increase in these bones’ length.
In addition, exercise was found not to reduce this negative effect of
methenolone enanthate. Although the prohibited substances classified as anabolics
are considered to increase performance by some athletes, these substances are
not recommended for use due to their negative effects on athletes’ health.

 

Keywords:
anabolic
steroids, methenolone enanthate, rats, femur, humerus

Keywords

anabolic steroids, methenolone enanthate, rats, femur, humerus

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