Abstract
Objectives
Acetylsalicylic acid (ASA) is the
most widely used as an analgesic, anti-inflammatory and antipyretic drug, and
also used to inhibit cyclooxygenase dependent platelet aggregation. The aim
of this study was to develop a simple, fast and accurate tandem mass method for
determination and quantification of ASA.
Methods
Chromatographic seperation was performed
using an Shimadzu LC-20-AD
with a ABSCIEX API 3200 triple quadrupole massspectrometer
Results
Intraassay CV values for acetylsalicylic
acid were 8% and 6% for 0.8 and 100 µg/L, respectively.
Discussion
The narrow therapeutic range of
these drugs are of importance to be analyzed at critical concentrations. This
method has capability to determine these levels.
Conclusion
We can conclude that the
developed method can be useful for clinical studies and routine therapeutic
drug monitoring with the desired precision and accuracy.
Keywords
Salicylic toxicity, tandem mass,
high performance, chromatography.
Acknowledgments: No conflict
of interest
Keywords
FAST DETECTION OF ACETYLSALICYLIC ACID BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY(LC-MSMS)
References
- Sedat Abusoglu*, Ali Unlu, Abdullah Sivrikaya Department of Biochemistry, SelcukUniversity Faculty of Medicine, Konya, Turkey
Abstract
References
- Sedat Abusoglu*, Ali Unlu, Abdullah Sivrikaya Department of Biochemistry, SelcukUniversity Faculty of Medicine, Konya, Turkey
Details
| Journal Section | Articles |
|---|---|
| Authors | |
| Publication Date | November 1, 2017 |
| Published in Issue | Year 2017 Volume 2, Issue 1(4) |