Bioactivities of Anacyclus pyrethrum (L.) Lag. extracts and natural products

Year 2020, , 55 - 61, 29.12.2020

Saravanan Vivekanandarajah Sathasivampillai , Sujarajini Varatharasan

https://doi.org/10.51435/turkjac.830501

Cited By: 2

Abstract

Anacyclus pyrethrum (L.) Lag. is an herb that fits into the Asteraceae family. It has been using to treat several disorders include lung infections, liver diseases, nervous system diseases, and rheumatism in ethnomedicines. Compounds including pellitorine, anacycline, spilanthol, pyracyclumine A, and agrocybenine have been isolated from this plant species. Thus, this overview work intends to scrutinize, sum up, and record the available bioactive scientific evidence of A. pyrethrum. This work would be very convenient for future bioactivity and phytochemical studies of this plant species. Electronic databases such as the Web of Science, Scopus, ScienceDirect, and PubMed were applied to identify appropriate published articles associated with bioactivities of A. pyrethrum from 1900 to November 2020. Until now, all three levels (clinical, in vivo, and in vitro) of bioactive scientific evidence are existing for various parts of this plant species. Bioactivities including anesthetic, antidepressant, antiepileptic, blood circulatory, and anticonvulsive activities in diverse assays and models. Seven antiprotozoal active compounds and an anti-inflammatory active compound have been identified in A. pyrethrum. More bioactivities and phytochemical linked researches should be conducted to generate more scientific evidence for the ethnomedicinal uses. This work scrutinized, summed up, and recorded the currently available bioactive scientific evidence of A. pyrethrum.

Keywords

Anacyclus pyrethrum, Asteraceae, Sri Lanka, Siddha Medicine, antioxidant

Supporting Institution

Not applicable

Project Number

Not applicable

Thanks

This work received no funding. The authors are grateful to their family members for their support to deliver this work.

References

• [1] V. K. Patel, R. V. Patel, H. Venkatakrishna‐Bhatt, G. Gopalakrishna, G. Devasankariah, A clinical appraisal of Anacyclus pyrethrum root extract in dental patients, Phytother Res, 6, 1992, 158–159.
• [2] M. Grieve, A Modern Herbal. The Medical, Culinary, Cosmetic and Economic Properties, Cultivation and Folklore Modern Scientific Uses, 1989, UK, Jonathoan Cape.
• [3] J. B. Althaus, C. Malyszek, M. Kaiser, R. Brun, T. J. Schmidt, Alkamides from Anacyclus pyrethrum L. and their in vitro Antiprotozoal Activity, Molecules, 22, 2017, 796.
• [4] K. Bezza, Z. El Gabbas, J. Laadraoui, M. A. Laaradia, S. Oufquir, A. Chait, Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism, Bangladesh J Pharmacol, 14, 2019, 188–195.
• [5] Kew Science, Anacyclus pyrethrum (L.) Lag.’, 2020, http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:941366-1
• [6] A. Mohammadi, B. Mansoori, P. C. Baradaran, S. C. Baradaran, B. Baradaran, Anacyclus pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest, J Gastrointest Cancer, 48, 2017, 333–340.
• [7] V. Sharma, J. Boonen, B. D. Spiegeleer, V. K. Dixit, Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC, Phytother Res, 27, 2013, 99–106.
• [8] V. Huerta, K. Mihalik, K. Beckett, V. Maitin, D. A. Vattem, Anti-diabetic and anti-energy harvesting properties of common traditional herbs, spices and medicinal plants from India, J Nat Remedies 2010, 10, 123–135.
• [9] H. Manouze, O. Bouchatta, A. C. Gadhi, M. Bennis, Z. Sokar, S. Ba-M’hamed, Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Methanol and Aqueous Extracts of Anacyclus pyrethrum Roots, Front. Pharmacol. 8, 2017, 598.
• [10] H. Manouze, O. Bouchatta, M. Bennis, Z. Sokar, S. Ba-M’hamed, Anticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice, Epilepsy Res, 158, 2019, 106225.
• [11] V. Rimbau, E. Risco, S. Canigueral, J. Iglesias, Anti-inflammatory Activity of Some Extracts from Plants used in the Traditional Medicine of North-African Countries, Phytother Res, 10, 1996, 421–423.
• [12] K. Canli, A. Yetgin, I. Akata, E. M. Altuner, Antimicrobial activity and chemical composition screening of Anacyclus pyrethrum root, Indian J Pharm Educ Res, 51, 2017, S244–S248.
• [13] C. Selles, M. E. A. Dib, N. Djabou, F. Beddou, A. Muselli, B. Tabti, J. Costa, B. Hammouti, Antimicrobial activity and evolution of the composition of essential oil from Algerian Anacyclus pyrethrum L. through the vegetative cycle, Nat Prod Res, 27, 2013, 2231–2234.
• [14] S. Hamimed, N. Boulebda, H. Laouer, A. Belkhiri, Bioactivity-guided isolation of alkamides from a cytotoxic fraction of the ethyl acetate extract of Anacyclus pyrethrum (L.) DC. roots., Curr Issues Pharm Medical Sci, 31, 2018, 180–185.
• [15] K. Muralikrishnan, S. Asokan, P. R. Geetha Priya, K. S. Zameer Ahmed, G, Ayyappadasan, Comparative Evaluation of the Local Anesthetic Activity of Root Extract of Anacyclus pyrethrum and its Interaction at the Site of Injection in Guinea Pigs, Anesth Essays Res, 11, 2017, 444–448.
• [16] A. Singh, Compendia of World’s Medicinal Flora, 2016, U.S.A., CRC Press.
• [17] M. Pahuja, J. Mehla, K. H. Reeta, M. Tripathi, Y. K. Gupta, Effect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice, Neurochem Res, 38, 2013, 547–556.
• [18] V. Sharma, M. Thakur, N. S. Chauhan, V. K. Dixit, Effects of petroleum ether extract of Anacyclus pyrethrum DC. on sexual behavior in male rats, Zhong Xi Yi Jie He Xue Bao, 8, 2010, 767–773.
• [19] V. Sharma, M. Thakur, N. S. Chauhan, V. K. Dixit, Evaluation of the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus Pyrethrum DC in Male Rats, Sci Pharm, 77, 2009, 97–110.
• [20] S. R. Badhe, R. V. Badhe, M. M. Ghaisas, V. V. Chopade, A. D. Deshpande, Evaluations of antidepressant activity of Anacyclus pyrethrum root extract, Int J Green Pharm, 4, 2010, 79–82.
• [21] N. D. Prajapati, S. S. Purohit, A. K. Sharma, T. Kumar, Handbook of Medicinal Plants: A Complete Source Book, 2003, India, Agrobios.
• [22] A. Usmani, M. Mujahid, M. Khushtar, H. H. Siddiqui, M. A. Rahman, Hepatoprotective effect of Anacyclus pyrethrum Linn. against antitubercular drug-induced hepatotoxicity in SD rats, J Complement Integr Med, 13, 2016, 295–300.
• [23] V. Sharma, M. Thakur, N. S. Chauhan, V. K. Dixit, Immunomodulatory activity of petroleum ether extract of Anacyclus pyrethrum, Pharm Bio, 48, 2010, 1247–1254.
• [24] F. Yousaf, M. Shahid, M. Riaz, A. Atta, H. Fatima, Immunomodulatory potential of Anacyclus pyrethrum (L.) and Mucuna pruriens (L.) In male albino rats, J Biol Regul Homeost Agents, 31, 2017, 425–429.
• [25] D. Bendjeddou, K. Lalaoui, D. Satta, Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis, J Ethnopharmacol, 88, 2003, 155–160.
• [26] D. Haghmorad, M. B. Mahmoudi, P. Haghighi, P. Alidadiani, E. Shahvazian, P. Tavasolian, M. Hosseini, M. Mahmoudi, Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats, Int Braz J Urol, 45, 2019, 1043–1054.
• [27] M. Riaz, M. Shahid, A. Jamil, M. Saqib, In vitro antioxidant potential of selected aphrodisiac medicinal plants, J Biol Regul Homeost Agents, 31, 2017, 419–424.
• [28] B. Müller-Jakic, W. Breu, A. Pröbstle, K. Redl, H. Greger, R. Bauer, In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species’, Planta Med, 60, 1994, 37–40.
• [29] V. K. Kumar, K. G. Lalitha, In vitro study on α-amylase inhibitory activity of an Ayurvedic medicinal plant, Anacyclus pyrethrum DC root’, Indian J Pharmacol, 46, 2014, 350–351.
• [30] K. Sukumaran, R. Kuttan, Inhibition of tobacco-induced mutagenesis by eugenol and plant extracts, Mutat Res/Genet Toxicol, 343, 1995, 25–30.
• [31] K. Sujith, D. C. Ronald, V. Suba, Inhibitory effect of Anacyclus pyrethrum extract on acetylcholinesterase enzyme by in vitro methods, Pharmacogn J, 4, 2012, 31–34.
• [32] P. Dioscorides, Kräuterbuch deß Uralten unnd in allerWelt berühmtesten Griechischen Scribenten Pedacii Dioscorides Anazarbaei, 1614, Germany, Corthoys.
• [33] J. Bellakhdar, La Pharmacopée Marocaine Traditionnelle, 1997, France, Ibis Press.
• [34] J. Boonen, V. Sharma, V. K. Dixit, C. Burvenich, B. D. Spiegeleer, LC-MS N-alkylamide Profiling of an Ethanolic Anacyclus pyrethrum Root Extract, Planta Med, 78, 2012, 1787–1795.
• [35] M. Adams, W. Alther, M. Kessler, M. Kluge, M. Hamburger, Malaria in the renaissance: Remedies from European herbals from the 16th and 17th century, J Ethnopharmacol, 133, 2011, 278–288.
• [36] R. Bentley, H. Trimen, Medicinal Plants, 2004, India, Asiatic Publishing House.
• [37] L. Boulos, M. Gohary, Medicinal Plants of North Africa, 1983, U.S.A., Reference Publications, Inc.
• [38] M. D. Kalim, D. Bhattacharyya, A. Banerjee, S. Chattopadhyay, Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine, BMC Complement Altern Med, 10, 2010, 77.
• [39] Q.B. Chen, J. Gao, G.A. Zou, X.L. Xin, H. A. Aisa, Piperidine Alkaloids with Diverse Skeletons from Anacyclus pyrethrum, J Nat Prod, 81, 2018, 1474–1482.
• [40] S. V. Sathasivampillai, P. R. S. Rajamanoharan, M. Munday, M. Heinrich, Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources, J Ethnopharmacol, 198, 2017, 531–599.
• [41] L. Veryser, N. Bracke, E. Wynendaele, T. Joshi, P. Tatke, L. Taevernier, B. De Spiegeleer, Quantitative in vitro and in vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine, Biomed Res Int, 2016, 5497402.
• [42] H. S. Puri, Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation, 2002, UK, CRC Press.
• [43] M. Pahuja, J. Mehla, K. H. Reeta, S. Joshi, Y. K. Gupta, Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals, Epilepsy Res, 98, 2012, 157–165.
• [44] S. V. Sathasivampillai, P. R. S. Rajamanoharan, M. Heinrich, Siddha Medicine in Eastern Sri Lanka Today-Continuity and Change in the Treatment of Diabetes, Front Pharmacol, 9, 2018, 1022.
• [45] D. Nirmala, Studies on anticonvulsant activity of Annacyclus pyrethrum in albino mice, Asian J Pharm Clin Res, 8, 2015, 178–187.
• [46] D. K. Singh, S. B. Babbar, B. A. Mir, Studies on Pellitorine Production and Antioxidant Activity of Explant Specific Calli of Anacyclus pyrethrum, J Biol Act Prod Nat, 10, 2020, 183–191.
• [47] N. Jalayer-Naderi, M. Niakan, E. Khodadadi, M. Mohamadi-Motlagh, The antibacterial activity of methanolic Anacyclus pyrethrum and Pistacia lentiscus L. extract on Escherichia coli, Iran J Microbiol, 8, 2016, 372–376.
• [48] S. K. Sharma, M. Gupta, R. Bhadauria, S. Amanullah, H. C. Chandramoorthy, V. A. Kumar, S. Khatheeja, O. T. Asekun, D. S. Grierson, A. J. Afolayan, The Ayurvedic Pharmacopoeia of India, Government of India, Ministry of Health and Family Welfare, 2004, India, Department of Indian System of Medicine and Homeopathy.
• [49] K. Sujith, R. Darwin, V. Suba, Toxicological evaluation of ethanolic extract of Anacyclus pyrethrum in albino Wistar rats, Asian Pac J Trop Dis, 2, 2012, 437–441.