Can Diet Dissociate Biological Aging from Chronological Age?

Muhammed Bartu Varol; Sema Pak; Fatma Zehra Aygur

doi:10.51536/tusbad.1808524

TR EN

Diyet Biyolojik Yaşlanmayı Kronolojik Yaştan Ayırabilir Mi?

Öz

Beslenme, organizmada meydana gelen biyolojik ve metabolik süreçler için gerekli olan besin ögelerinin vücuda alınması ve kullanılmasıdır. Yeterli ve dengeli beslenme; kardiyovasküler ve nörolojik fonksiyonların desteklenmesi, homeostazın sürdürülmesi ve sağlıklı yaşlanma sürecinin desteklenmesi ile ilişkilidir. Bireye ait beslenme durumu, organizmada biyolojik yaşlanma süreçleri ile ilişkili olan rapamisinin mekanistik hedefi kompleks 1 (mTORC1), AMP ile aktive olan protein kinaz (AMPK), sirtuinler ve insülin/insülin benzeri büyüme faktörü sinyal yolağı (IIS) gibi çeşitli metabolik yolakları modüle edebilir. Beslenme durumu ayrıca hücre bölünme kapasitesinin bir göstergesi olan telomer uzunluğu ile immün yanıt süreçleri üzerinde potansiyel etkileriyle yaşlanma sürecinde rol oynayabilir. Bu noktada, farklı bölgelerde benimsenen beslenme modellerinin ve spesifik diyet yaklaşımlarının, hastalık riskleri ile beklenen yaşam süresi üzerine etkilerinin aydınlatılması büyük önem taşımaktadır. Bu bağlamda bu derlemenin amacı; Batı tipi diyet, Akdeniz diyeti ve Okinawa diyeti gibi beslenme modelleri ile aralıklı oruç, enerji, protein ve amino asit kısıtlaması gibi diyet yaklaşımlarının yaşlanma süreçleri ile ilişkisini mevcut literatür temelinde incelemek ve sentezlemektir.

Anahtar Kelimeler

Beslenme durumu , Diyet , Uzun ömürlülük , Sağlıklı yaşlanma

Can Diet Dissociate Biological Aging from Chronological Age?

Abstract

Nutrition is the intake and utilization of nutrients required for the biological and metabolic processes of the organism. Adequate and balanced nutrition is linked to regulating cardiovascular and neurological functions, maintaining homeostasis and promoting healthy aging. Nutritional status may modulate metabolic pathways associated with biological aging processes, including mechanistic target of rapamycin complex 1 (mTORC1), AMP-activated protein kinase (AMPK), sirtuins and insulin/insulin-like growth factor signaling (IIS) pathway. This may also play a role in aging process through its potential effects on immune response and telomere length, an indicator of cell division capacity. In this context, it is important to elucidate the effects of specific dietary interventions and dietary patterns adopted in different regions on disease risk and life expectancy. Therefore, the objective of the present study is to examine and synthesize current literature regarding the relationship between aging process and dietary patterns such as the Western diet, the Mediterranean diet and the Okinawan diet as well as dietary interventions like intermittent fasting and calorie, protein and amino acid restriction.

Keywords

Diet , Healthy aging , Longevity , Nutritional status

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Details

Primary Language

English

Subjects

Public Health Nutrition , Nutrition and Dietetics (Other)

Journal Section

Review

Authors

Muhammed Bartu Varol ^*
0009-0004-9309-6159
Türkiye

Sema Pak
0009-0007-4918-7864
Türkiye

Fatma Zehra Aygur
0009-0006-1737-0157
Türkiye

Publication Date

April 30, 2026

Submission Date

October 22, 2025

Acceptance Date

April 29, 2026

Published in Issue

Year 2026 Volume: 9 Number: 1

DOI

https://doi.org/10.51536/tusbad.1808524

IZ

https://izlik.org/JA23XZ88LF

APA

Varol, M. B., Pak, S., & Aygur, F. Z. (2026). Can Diet Dissociate Biological Aging from Chronological Age? Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi, 9(1), 29-46. https://doi.org/10.51536/tusbad.1808524

AMA

1.Varol MB, Pak S, Aygur FZ. Can Diet Dissociate Biological Aging from Chronological Age? Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. 2026;9(1):29-46. doi:10.51536/tusbad.1808524

Chicago

Varol, Muhammed Bartu, Sema Pak, and Fatma Zehra Aygur. 2026. “Can Diet Dissociate Biological Aging from Chronological Age?”. Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi 9 (1): 29-46. https://doi.org/10.51536/tusbad.1808524.

EndNote

Varol MB, Pak S, Aygur FZ (April 1, 2026) Can Diet Dissociate Biological Aging from Chronological Age? Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 9 1 29–46.

IEEE

[1]M. B. Varol, S. Pak, and F. Z. Aygur, “Can Diet Dissociate Biological Aging from Chronological Age?”, Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi, vol. 9, no. 1, pp. 29–46, Apr. 2026, doi: 10.51536/tusbad.1808524.

ISNAD

Varol, Muhammed Bartu - Pak, Sema - Aygur, Fatma Zehra. “Can Diet Dissociate Biological Aging from Chronological Age?”. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 9/1 (April 1, 2026): 29-46. https://doi.org/10.51536/tusbad.1808524.

JAMA

1.Varol MB, Pak S, Aygur FZ. Can Diet Dissociate Biological Aging from Chronological Age? Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. 2026;9:29–46.

MLA

Varol, Muhammed Bartu, et al. “Can Diet Dissociate Biological Aging from Chronological Age?”. Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi, vol. 9, no. 1, Apr. 2026, pp. 29-46, doi:10.51536/tusbad.1808524.

Vancouver

1.Muhammed Bartu Varol, Sema Pak, Fatma Zehra Aygur. Can Diet Dissociate Biological Aging from Chronological Age? Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. 2026 Apr. 1;9(1):29-46. doi:10.51536/tusbad.1808524

Diyet Biyolojik Yaşlanmayı Kronolojik Yaştan Ayırabilir Mi?

Öz

Anahtar Kelimeler

Can Diet Dissociate Biological Aging from Chronological Age?

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite