Protective Effects of Carvacrol, Essential Composition of Thyme Plant, on Cyclophosphamide-induced Reproductive System Damage on Rats

Abstract

Cyclophosphamide (CP) is an alkylating drug widely used clinically for the treatment of cancer and non - malignant diseases. However, the use of CP causes cytotoxicity in one or more tissues. In this study, it was aimed to determine possible protective effects of carvacrol (Car) which is the main component of thyme plant with antioxidant properties on CP (50 and 100 mg kg-1 ) testis toxicity. In the study, 35 male Sprague-Dawley rats were divided into 5 gro up s as 7 animals in each group. According to histological and biochemical findings, Car was found to provide meaningful protection in the prevention of testicular damage caused by CP. According to the results of the research, carvacrol is a highly effective antioxidant and cell protector. For this reason, Car may be an effective candidate for reducing side effects of anticancer drugs in chemotherapy protocols.

Keywords

• Cyclophosphamide
• testis damage
• carvacrol
• cell protector
• rat

Kekik Bitkisinin Temel Bileşeni Olan Karvakrolün Sıçanlarda Siklofosfamid Nedenli Üreme Sistemi Hasarı Üzerine Koruyucu Etkileri

Abstract

Siklofosfamid (CP) klinikte kanser ve non-malignant hastalıkların tedavisinde yaygın olarak kullanılan alkilleyici bir ilaçtır. Ancak CP kullanımı bir veya birden fazla dokuda sitotoksisiteye neden olmaktadır . Bu çalışmada CP (50 ve 100 mg kg-1) testis toksisitesi üzerine kekik bitkisinin temel bileşeni olan ve antioksidan özellikleri bilinen karvakrol (Car)’ün olası koruyucu etkilerini saptamak amaçlanmıştır. Çalışmada, Sprague-Dawley cinsi 35 adet erkek sıçan her grupta 7 hayvan olacak şekilde 5 gruba ayrılmıştır. Histolojik ve biyokimyasal bulgulara göre, CP nedenli testis hasarının önlenmesinde Car anlamlı bir koruma sağladığı saptanmıştır. Araştırma sonuçlarına göre elde edilen veriler, karvakrolün oldukça etkili bir antioksidan ve hücre koruyucu olduğunu göstermiştir. Bu nedenle Car, kemoterapi protokollerinde antikanser ilaçların yan etkilerinin azaltılmasında etkili bir aday olabilir.

Keywords

• Siklofosfamid
• testis hasarı
• karvakrol
• hücre koruyucu
• sıçan

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