The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats

Year 2017, , 275 - 280, 31.10.2017

Ferda Arı , Egemen Dere , Hakan Tosunoğlu İmren Alioğlu

https://doi.org/10.19159/tutad.310371

Abstract

Fenarimol and methyl
parathion are pesticides that have been used in agriculture for several years. These pesticides have significant effects on
environmental and human health.
Therefore, we investigated the effects of methyl parathion and fenarimol
on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The
glucose 6-phosphate dehydrogenase is the first enzyme
of the pentose phosphate pathway and it’s important in detoxifying reactions by
NADPH generated. In this study, wistar rats administrated with methyl parathion (7 mg.kg^–1) and fenarimol (200 mg.kg⁻¹) by
intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose
6-phosphate dehydrogenase enzyme
activity was assayed in liver, kidney, brain and small intestine in male
and female rats. The exposure of fenarimol and methyl parathion caused increase of glucose 6-phosphate dehydrogenase enzyme activity in rat tissues especially last periods. We
suggest that this increment of enzyme activity may be reason of toxic effects
of fenarimol and methyl parathion.

Keywords

Glucose 6-phosphate dehydrogenase, Fenarimol, Methyl parathion, Pesticide

The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats

Abstract

Fenarimol and methyl
parathion are pesticides that have been used in agriculture for several years. These pesticides have significant effects on
environmental and human health.
Therefore, we investigated the effects of methyl parathion and fenarimol
on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The
glucose 6-phosphate dehydrogenase is the first enzyme
of the pentose phosphate pathway and it is important in detoxifying reactions
by NADPH generated. In this study, wistar albino rats administrated with
methyl parathion (7 mg kg^–1) and fenarimol (200 mg kg⁻¹) by
intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose
6-phosphate dehydrogenase enzyme activity
was assayed in liver, kidney, brain, and small intestine in male and female
rats. The exposure of fenarimol and methyl
parathion caused increase of glucose
6-phosphate dehydrogenase enzyme activity
in rat tissues, especially at last periods. We suggest that this increment of
enzyme activity may be the reason of toxic effects of fenarimol and methyl parathion.

Keywords

Glucose 6-phosphate dehydrogenase, fenarimol, methyl parathion, pesticide

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