Diastereoselective Synthesis of 3,4-Dıbenzoil-3,4-Dihydro-1H-Spiro [Benzo[cd]Indol-5,3'-Indoline]-2,2’(2aH)-Diones

Year 2019, Volume: 1 Issue: 1, 20 - 23, 01.02.2019

Natalia Sucman Vsevolod Pogrebno Veceslav Boldescu Fliur Macaev

Abstract

Diastereoselective syntheses of 3,4-dibenzoyl-3,4-dihydro-1H-spiro[benzo[cd]indole-5,3'-indoline]-2,2'(2aH)-dionesin boiling DMF have been carried out starting with 3-(2-phenyl-2-oxoethylidene)indolin-2-ones via a Diels-Alder addition reaction. Theoretical and practical investigations of structure-activity relationships in the group of synthesizedspirooxindoleshave been performed.

Keywords

Oxindoles, spirooxindoles, dimerisation, Diels-Alder reaction

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