Bir Köpekte Malignant Perikardiyal Mezotelyoma ve Perikardiyal Efüzyon

Year 2009, Volume: 28 Issue: 2, 73 - 82, 01.06.2009

Meriç Kocaturk Hakan Salcı Aylin Alasonyalılar - Demirer Nureddin Çelimli

Abstract

Keywords

-

Bir Köpekte Malignant Perikardiyal Mezotelyoma ve Perikardiyal Efüzyon

Abstract

Kliniğimize kilo kaybı, abdominal dilatasyon, kollaps ve egzersiz intoleransı şikâyetiyle getirilen 15 yaşlı, erkek, Terrier ırkı bir köpeğe malignant perikardiyal mezotelyomaya bağlı perikardiyal efüzyon (PE) tanısı konuldu. Klinik muayenesinde aritmi, zayıf femoral nabız, kardiyak seslerde boğukluk ve juguler dolgunluk belirlendi. EKG’de QRS ile ilgili küçük kompleks oluşumu ve elektrik alternans, toraks radyografisinde; kalbin siluetinde opasite artışı ve pulmoner ödem, ekokardiyografide; PE ve kardiyak tamponat, abdominal ultrasonografide de asites saptandı. Hematolojik ve serum biyokimyasal bulgular ile perikardiyosentez sıvısının sitolojik muayenesi nonspesifikti. İdiopatik PE tedavisine (ampisilin + prednizolon) yanıt alınamayan hastaya bir ay sonra parsiyel perikardiyektomi yapılmasına karar verildi. Postoperatif kardiyopulmoner arrest nedeni ile hastada eksitus letalis şekillendi. Nekropsi muayenesi sonrası doku örnekleri alındı. Perikardiyumdaki neoplastik kitle, makroskobik, mikroskobik ve immunohistokimyasal özellikleri ile perikardiyal epitelyal mezotelyoma olarak tanımlandı. Sonuç olarak EKG ve ekokardiyografinin PE tanımlamasında yüksek doğruluk derecesinde kullanılabilecekleri, mezotelyoma gibi perikardiyal kitlelerin tanısında yetersiz kalınılabileceği gözlendi. İleri yaşlı PE’li köpeklerin tanısal sürecinde mezotelyomanın da düşünülmesi gerektiği kanısına varıldı

Keywords

Perikardiyal efüzyon, mezotelyoma, köpek

References

• Aronson, L., Gregory, C., 1995. Infectious peri- cardial effusion in 5 dogs. Vet. Surg., 24, 402-407.
• Berg, R.,Wingfeld, W., 1984. Pericardial effusion in the dog: A review of 42 cases. J. Am. Anim. Hosp. Assoc., 20, 721-730.
• Berrett, J.C., 1991. Role of chromosome muta- tions in asbestos-induced cell transformation. In. Harris CC, Lechner JF, (eds.), Cellular and Mo- lecular Aspects of Fiber Carcinogenesis. Plain- view, TX, Cold Spring Harbor Lab Press, pp. 27- 39.
• Bonagura, J. D., Pipers, F.S., 1981. Echocardio- graphic features of pericardial effusion in dogs. J. Am. Vet. Med. Assoc., 179, 49-56.
• Bouvy, B., Bjorling, D., 1991. Pericardial effusion in dogs and cats, part 1: Normal pericardium and causes and pathophysiology of pericardial effu- sion. Comp. Cont. Educ. Pract., 13, 417-424.
• Bruch, C., Schmermund, A., Dagres, N., Bartel, T., Caspari, G., Sack, S., Erbel, R., 2001. Changes in QRS voltage in cardiac tamponade and pericardial effusion: reversibility after pericardiocentesis and after anti-inflammatory drug treatment. J. Am. Coll. Cardiol., 38, 219-26.
• Carbone, M., Kratzke, R.A., Tst, J.R. 2002. The pathogenesis of mesothelioma. Semin Oncol, 29:2–17.
• Cihak, R.W., Roen, D.R., Klaassen, J., 1986. Malignant mesothelioma of the tunica vaginalis in a dog. J Comp Pathol., 96, 459-462.
• Closa, J.M., Font, A., Ascort, J., 1999. Pericardial mesothelioma in a dog: long-term survival after pericardiectomy in combination with chemother- apy. J Small Anim Prac, 40, 383–386.
• Cobb, M.A., Brownlie, S.E., 1992. Intrapericar- dial neoplasia in 14 dogs. J Small Anim Prac, 33, 309–316.
• Dubielzig, R.R., 1979. Sclerosing mesothelioma in five dogs. J Am Anim Hosp Assoc., 15, 745- 748.
• Dunning, D., Monnet, E., Orton, C., Salman, M., 1998. Analysis of prognostic indications for dogs with pericardial effusion: 46 cases (1985-1996). J. Am. Vet. Med. Assoc., 212, 1279-1280.
• Edwards, N.J., 1996. The diagnostic value of pericardial fluid pH determination. J. Am Anim Hosp Assoc, 32, 63-67.
• Erer, H., Kıran, M.M., 2005. Veteriner Onkoloji, 3. basım, Damla Ofset A.Ş., sf. 101-102.
• Fossum, T.W., 2002. Small Animal Surgery. Second Edition, Chapter 29. Mosby, St Louis, pp. 701-715.
• Garrlet, L.D., Macewen, E.G., 2001. Meso- thelioma. In. Small Animal Clinical Oncology, 3rd Edit., S.J. Witrow, E.G. Mavewen (Eds.), W.B. Saunders, Philadelphia, pp. 656–661.
• Geninet, C., Bernex, F., Rakotovao, F., Crespeau, F.L., Parodi, A.L., Fontaine, J.J., 2003. Sclerosing peritoneal mesothelioma in a dog—a case report. J Vet Med A, 50, 402–405.
• Gibbs, C., Gaskell, C., Darke, P.,Wotton, P., 1982. Idiopathic pericardial heamorrhage in dogs: A review of fourteen cases. J. Small Anim. Pract., 483-500.
• Glickman, L.T., Domanski, L.M., Magiure, T.G., 1983. Mesothelioma in pet dogs associated with exposure of their owners to asbestos. Environ Res., 32, 305-313.
• Harbison, M.L., Godleski, J.J., 1983. Malignant mesothelioma in urban dogs. Vet Pathol, 20, 531– 540.
• Head, K.W., Else, R.W., Dubielzig, R.R. 2002. Tumors of the alimentary tract. In. Tumors in Domestic Animals, Meuten DJ (Eds.), 4th edit., Iowa State Press, Ames, IA, pp.477–478.
• Hesterberg, T.W., Barrett, J.C., 1985. Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Carcinogenesis, 6, 473–475.
• Ikede, B.O., Zubaidy, A., Gill, C.W., 1980. Peri- cardial mesothelioma with cardiac tamponade in a dog. Vet Pathol, 17, 496–500.
• Kienle, R.D. 1998. Pericardial disease and cardiac neoplasia. In. Small Animal Cardiovascular Medicine, M.D. Kittleson, R.D. Kienle, (Eds.), Mosby, St Louis, pp. 413–432.
• McDonough, S.P., Mac Lachlan N.J., Tobias, A. H., 1992. Canine pericardial mesothelioma. Vet Pathol, 29, 256–260.
• Mutsaers, S.E., 2004. The mesothelial cell. Int J Biochem Cell Biol, 36, 9–16.
• Ordenez, N.G., 2002. Immunohistochemical diag- nosis of epithelioid mesotheliomas: a critical re- view of old markers, new markers. Hum Pathol, 33, 953–967.
• Petrus, D., Henik, R., 1999. Pericardial effusion and cardiac tamponade secondary to brodifacoum toxicosis in a dog. J. Am. Vet. Med. Assoc., 215, 647-648.
• Regetti, F., Brisson, B., Ruotsalo, K., Southorn, E., Bienzle, D., 2005. Invazive Epithelial Meso- thelioma in a Dog. Vet Pathol, 42, 77-81.
• Reider, C.L., Sluder, G., Brinkey, B.R., 1991. Some possible routes for asbestos-induced ane- uploidy during mitosis in vertebrate cells. In. Har- ris CC, Lechner JF, (eds.), Cellular and Molecular Aspects of Fiber Carcinogenesis. Plainview, TX, Cold Spring Harbor Lab Press, pp. 1-26.
• Salcı, H., 2006. Köpeklerde pnömonektomi son- rası farklı bronş kapatılma tekniklerinin karşı- laştırılması, Doktora tezi, Bursa.
• Salci, H., Kennerman, E., Celimli, N., Torun, S., 2005. Use of Heimlich flutter valve in a dog with spontaneous pneumothorax. Aust Vet Prac, 35, 47-51.
• Shaw, S. P., Rush, J. E., 2007. Canine Pericardial Effusion: Diagnosis, Treatment, and Prognosis. Compendium, 405-411.
• Sisson, D., Thomas, W., 1999. Pericardial disease. In. Textbook of Canine and Feline Cardiology Principles and Clinical Practice – II., Fox, P.R., Moise, N.S. (Eds.), W.B. Sounders Co., Philael- phia, pp. 668-669.
• Smith, F., Rush, J., 1999. Current Veterinary Therapy XIII. In. Kirk, R., Bonagure, J., (Eds.), Diagnosis and treatment of pericardial effusion. W.B. Saunders Co., Philadelphia, pp. 722-777.
• Stephen, R., Withley, N., Dubielzig, R., 2000. Idiopathic or mesothelioma-related pericardial ef- fusion: Clinical findings and survival in 17 dog studied retrospectively. J. Small Anim. Pract., 41, 342-347.
• Thrall, D.E., Goldschmidt, M.H., 1978. Meso- thelioma in the dog: Six case reports. J Am Vet Res, 19, 107-115.
• Ware, W.A., Hopper, D.L., 1999. Cardiac tumors in dogs: 1982–1995. J Vet Inter Med, 13, 95–103.
• Wilson, D.W., Dungworht D.L., 2002. Tumors of the respiratory tract. In. Tumors in Domestic Animals, 4th Edit., D.J. Meuten (Ed.), Iowa State Press, Ames, pp. 365–399.
• Withrow, S.J., MacEwen, E.G., 2001. Small Nai- mal Oncology, 3rd Edit, Saunders, Philedelphia, pp. 656-661.