APPLİCATİONS OF HUMAN PLACENTAL CHORİON-INDUCED PLURİPOTENT CELLS FOR TİSSUE ENGİNEERİNG

Yıl 2024, Cilt: 6 Sayı: 2, 93 - 104, 31.12.2024

Sude Naz Çataltepe , Nigar Sahra Karabul , Yağmur Kırbayır , Hatice Bashir , Pelin Saraçoğlu , Murat Ihlamur

https://doi.org/10.55440/umufed.1535418

Öz

Stem cells, which have an enormous capability of self-renewal and transform into many diverse cell types in the body early in lifespan and during growth, have been heavily researched in recent years. Stem cells are specialized cells that can regenerate and repair damaged or diseased organs in humans. Stem cells are employed for regenerative medicine and tissue engineering. Thus, beneficial outcomes are observed in the treatment of many disorders and faulty tissues. Mesenchymal stem/stromal cell lines (abbreviated as MSCs) isolated from fetal and adult tissues are of considerable interest for use in tissue engineering and cell therapeutics thanks to their ability to emigrate, regenerate, and repair injured sites. In this review study, induced pluripotent cells were derived from human placental chorion to advance tissue engineering technologies and investigate therapeutic approaches to various disorders.

Anahtar Kelimeler

Stem cell, Human Placental Chorion, Tissue Engineering, iPSC, CMSC

DOKU MÜHENDİSLİĞİ İÇİN İNSAN PLASENTAL KORYONUNDAN GELİŞTİRİLEN PLURİPOTENT HÜCRELERİN UYGULAMALARI

Öz

Yaşamın erken dönemlerinde ve büyüme sırasında vücutta çok çeşitli hücre tiplerine dönüşebilen ve kendini yenileme konusunda muazzam bir yeteneğe sahip olan kök hücreler son yıllarda yoğun bir şekilde araştırılmıştır. Kök hücreler, insanlarda hasarlı veya hastalıklı organları yenileyebilen ve onarabilen özel hücrelerdir. Kök hücreler rejeneratif tıp ve doku mühendisliği için kullanılır. Bu nedenle, birçok rahatsızlığın ve hatalı dokunun tedavisinde faydalı sonuçlar gözlemlenir. Fetal ve yetişkin dokulardan izole edilen mezenkimal kök/stromal hücre hatları (kısaca MSC'ler), göç etme, yenilenme ve yaralı bölgeleri onarma yetenekleri sayesinde doku mühendisliği ve hücre terapötiklerinde kullanım için önemli ilgi görmektedir. Bu inceleme çalışmasında, doku mühendisliği teknolojilerini ilerletmek ve çeşitli rahatsızlıklara yönelik terapötik yaklaşımları araştırmak için insan plasenta koryonundan indüklenmiş pluripotent hücreler türetilmiştir.

Anahtar Kelimeler

Kök hücre, İnsan Plasenta Koryonu, Doku Mühendisliği, iPSC, CMSC

Kaynakça

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