Retinopathy of Prematurity and Intravitreal Bevacizumab Treatment: Single Center Experience

Abstract

In this study, the frequency of retinopathy of prematurity (ROP) in premature infants born in a tertiary state hospital, and the characteristics of infants with ROP and requiring treatment were investigated. In addition, experiences regarding the treatment and follow-up processes applied for RROP were shared. In the study, the data of premature babies born before 35 weeks were analyzed retrospectively. The data of infants with and without treatment indication among infants who developed ROP were compared. In the study, the data of 112 infants who were treated in our unit over two years and followed up for ROP were evaluated. The mean gestational age of the babies was 28.37±2.55 weeks, and the mean birth weight was 1171.66±405.17 grams. ROP was detected in 44 (39.2%) of the babies. Among infants who developed ROP, those who received treatment indication (n: 10) were infants with lower birth weight and higher inotrope requirement (p<0.05). ROP was not detected in premature babies born at 30 weeks or more. The highest birth week of babies who developed severe ROP was 27. As a treatment, intravitreal bevacizumab injection was successfully applied. The age of detection of ROP is advancing towards lower weeks in our country. Intravitreal bevacizumab is an effective and short-term safe treatment method that can be applied at the bedside.

Keywords

• Bevacizumab
• retinopathy of prematurity
• vascular endothelial growth factor

Prematüre Retinopatisi ve İntravitreal Bevacizumab Tedavisi: Tek Merkez Deneyimi

Abstract

Bu çalışmanın amacı üçüncü basamak bir devlet hastanesinde doğan prematüre bebeklerdeki prematüre retinopatisi (ROP) sıklığı, ROP saptanan ve tedavi gereken bebeklerin özellikleri, uygulanan tedavi ve takip süreçleri ile ilgili deneyimlerin paylaşılmasıdır. Çalışmada 35 haftadan erken doğan prematüre bebeklerin verileri retrospektif olarak incelendi. ROP gelişen bebekler içinde tedavi endikasyonu konan ve konmayan bebeklerin verileri karşılaştırıldı. Çalışmada iki yıllık süre içerisinde ünitemizde tedavi görmüş ve ROP açısından takipleri tamamlanmış olan, 112 bebeğin verileri değerlendirildi. Bebeklerin ortalama gestasyonel yaşı 28,37±2,55 hafta, ortalama doğum ağırlığı 1171,66±405,17 gram idi. Bebeklerin 44 tanesinde (%39,2) ROP saptandı. ROP gelişen bebekler arasında tedavi endikasyonu alanlar (n: 10) daha düşük doğum ağırlığı ve daha yüksek oranda inotrop gereksinimi olan bebeklerdi (p<0.05). Otuz hafta ve üzerinde doğan prematüre bebeklerde ROP saptanmadı. Ciddi ROP gelişen bebeklerin en yüksek doğum haftası 27 idi. Tedavi olarak intravitreal bevacizumab enjeksiyonu başarılı ile uygulandı. Sonuç olarak ROP saptanma yaşı ülkemizde daha düşük haftalara doğru gerilemektedir. İntravitreal bevacizumab hasta başında uygulanabilen etkin ve kısa dönemde güvenilir bir tedavi yöntemidir.

Keywords

• Bevacizumab
• prematüre retinopatisi
• vasküler entotelyal büyüme faktörü

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