Fibromiyalji Sendromunda Sistemik İmmün-İnflamasyon İndeksi ve Hematolojik Laboratuvar Bulgularına Genel Bakış

Yıl 2024, , 131 - 136, 08.10.2024

Pınar Ellergezen , Alev Alp , Sinan Çavun , Gülce Sevdar Çeçen

https://doi.org/10.32708/uutfd.1440205

Öz

Bu çalışmada fibromiyalji sendromunda (FMS) Sistemik İmmün-İnflamasyon İndeksi (SII) ile kan parametreleri arasındaki ilişki değerlendirilerek hastalık aktivitesinin belirlenmesi amaçlanmıştır. Çalışmaya Ocak 2021 ve Ocak 2022 tarihleri arasında Fizik Tedavi ve Rehabilitasyon Kliniğine başvuran 109 FMS hastası ve 82 sağlıklı kontrol dahil edilmiştir. Yaş, cinsiyet, C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR), beyaz kan hücresi (WBC), hemoglobin (HGB), ortalama korpusküler hacim (MCV), ortalama korpusküler hemoglobin (MCH), ortalama korpusküler hemoglobin konsantrasyonu (MCHC), kırmızı hücre dağılımı (RDW), trombosit dağılım genişliği (PDW), ortalama trombosit hacmi (MPV), trombosit (PLT), trombosit kriteri (PCT), lenfosit (LYM), monosit (MONO), nötrofil (NEU) düzeyleri hastane bilgi sisteminden retrospektif olarak taranmıştır. Trombosit-lenfosit oranı (PLR), nötrofil-lenfosit oranı (NLR), monosit-lenfosit oranı (MLR) ve sistemik immün-inflamasyon indeksi (SII) hesaplanmıştır. CRP ve ESR düzeyleri FMS hastalarında sağlıklı kontrollere göre daha yüksekti ancak değer aralığının dışında değildi (p<0,001). PDW (p<0,001), HGB (p<0,001), MCV (p<0,001), MCH (p<0,001) ve MCHC (p=0,02) düzeyleri hastalarda sağlıklı gruba göre daha düşüktü. Hasta ve kontrol grupları arasında yaş, WBC, NEU, LYM, MONO, RDW, MPV, PLT, PCT, SII, PLR, NLR ve MLR değerleri açısından istatistiksel olarak anlamlı fark yoktu. FMS hastalarında WBC düzeyleri ile SSS değerleri arasında (r=0,2; p=0,005) ve lenfosit düzeyleri ile WPI değerleri arasında (r=0,2; p=0,01) anlamlı pozitif korelasyon bulunmuştur. Çalışma sonuçlarına göre, SII'nin FMS'de belirleyici bir rolü yoktur, ancak hastalığın tanıda yararlı olabilecek bazı inflamatuvar bileşenleri vardır ve daha ayrıntılı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Fibromiyalji sendromu, inflamatuvar belirteç, sistemik immün inflamasyon indeksi

An Overview of Systemic Immune-Inflammatıon Index and Hematological Laboratory Findings in Fibromyalgia Syndrome

Öz

This study aimed to determine disease activity by evaluating the relationship between the Systemic Immune-Inflammation Index (SII) and blood parameters in fibromyalgia syndrome (FMS). 109 FMS patients and 82 healthy controls were included in this retrospective study. Age, gender, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution (RDW), platelet distribution width (PDW), mean platelet volume (MPV), platelet (PLT), platelet crit (PCT), lymphocyte (LYM), monocyte (MONO), neutrophil (NEU) levels were scanned retrospectively from the hospital information system. Platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and SII were calculated. CRP and ESR levels were elevated in fibromyalgia (FMS) patients compared to healthy controls, although they remained within the standard value range (p<0.001). PDW (p<0.001), HGB (p<0.001), MCV (p<0.001), MCH (p<0.001), and MCHC (p=0.02) levels were lower in patients than in the healthy group. There was no discernable age difference between the patient and control groups, WBC, NEU, LYM, MONO, RDW, MPV, PLT, PCT, SII, PLR, NLR, and MLR values. A significant positive correlation was detected between WBC levels and SSS values (r=0.2; p=0.005) and lymphocyte levels and WPI values (r=0.2; p=0.01) in FMS patients. According to the results of this study, SII has no decisive role in FMS, but the disease exhibits distinct inflammatory factors that could be valuable for diagnostic purposes, so more detailed studies are needed.

Anahtar Kelimeler

Fibromyalgia syndrome, inflammatory marker, systemic immune inflammation index

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