Nörolojik Hastalıklarda Beş Yıllık Plazma Değişim Deneyimi, Tek Merkez Çalışması

Year 2024, , 531 - 536, 12.01.2025

Metin Ergül , Şerife Şeyda Zengin Acemoğlu , Kemal Aygün , Elif Işınsu Başoğlu , Ömür Gökmen Sevindik , Fatih Demirkıran

https://doi.org/10.32708/uutfd.1584013

Abstract

Terapötik plazmaferez değişimi (TPD) tedavisi birçok nörolojik hastalıkta başarıyla kullanılmaktadır. Merkezimizde TPD çeşitli diğer hastalıkların yanı sıra birçok nörolojik vakada kullanılmaktadır. Bu çalışmada, Ocak 2010 ile Aralık 2014 arasında TPD uygulanan hastaların verileri analiz edildi. Toplamda 775 seans, 114 siklus ve 86 hastanın verileri değerlendirildi ve analiz edildi. Ortanca yaş 49,8 idi. 75 hasta nöroloji bölümünde, 11 hasta ise dahiliye yoğun bakım ünitesi'nde takip edildi. Plazmaferez için en sık endikasyonlar myastenia gravis, multipl skleroz ve polinöropatilerdi (sırasıyla %35, %21, %9.3). TPD'de replasman sıvısı olarak Taze Donmuş Plazma (TDP) kullanılanlarda albumin kullanılanlara göre çok daha az hipotansiyon gelişti [sırasıyla 2 (%0.9);25(%4.4)](p<0.05). 114 siklus değerlendirildiğinde siklusların %92’sinde klinik yanıt vardı. Nörolojik hastalıklarda TPD, minimal yan etki ile yüksek klinik yanıt oranına sahip güvenli bir prosedür olarak kabul edilir.

Keywords

Plazmaferezin komplikasyonları, Myastenia gravis, Nörolojik hastalıklar, Plazma Değişimi

Five Years Plasma Exchange Experience In Neurological Diseases, Single Center Study

Abstract

Therapeutic plasmapheresis exchange (TPE) treatment is used successfully in many neurological diseases. At our center, TPE is used in many neurological cases in addition to various other diseases. In this study, data of patients who underwent TPE between January 2010 and December 2014 were analyzed. In total, 775 sessions, 114 cycles, and 86 patients’ date were evaluated and analyzed. The median age was 49.8 years. 75 patients were followed in the neurology department and 11 patients were followed in the internal medicine intensive care unit. The most common indications for plasmapheresis were myasthenia gravis, multiple sclerosis, and polyneuropathies (respectively, %35, %21, %9.3). In TPE, hypotension developed much less in those using Fresh Frozen Plasma (FFP) as replacement fluid compared to those using albumin [respectively, 2 (%0.9); 25(%4.4)] (p<0.05). When 114 cycles were evaluated, there was a clinical response in 92% of the cycles. TPE in neurological diseases is considered a safe procedure with a high clinical response rate with minimal side effects.

Keywords

Complications of plasmapheresis, Myasthenia gravis, Neurological diseases, Plasma Exchange, Polyneuropathy

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