Research Article

Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden

Volume: 52 March 16, 2026
TR EN

Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden

Abstract

Oxidative stress and systemic inflammation are increasingly recognized as key mechanisms in migraine pathophysiology. Uric acid (UA) and albumin (ALB) contribute to redox and inflammatory balance, and their ratio (UAR) has been proposed as a combined biomarker of these processes. This study evaluated serum UA, ALB, and UAR levels in patients with episodic migraine during the interictal period and examined their associations with clinical features and migraine-related disability. In this retrospective case–control study, 120 patients with episodic migraine and 100 age- and sex-matched healthy controls were included. Serum UA and ALB were measured, and UAR was calculated as UA (mg/dL)/ALB (g/dL). Demographic and laboratory variables were compared between groups. In the migraine group, correlations between biochemical markers and clinical variables, including pain intensity (VAS), migraine-related disability (MIDAS), attack frequency, and aura status, were analyzed. Serum UA and UAR levels were significantly lower in migraine patients than in controls (both p<0.001), whereas ALB levels were similar. UA, ALB, and UAR were not correlated with attack frequency, pain intensity, MIDAS scores, or aura status. Lower UA and UAR levels in episodic migraine may reflect reduced systemic antioxidant capacity. However, the absence of associations with clinical severity suggests that oxidative imbalance may not directly represent migraine burden. UAR may serve as a biochemical indicator of oxidative and inflammatory processes in migraine. Further prospective studies are needed to clarify its clinical relevance.

Keywords

Supporting Institution

none

Ethical Statement

Approving Committee: Bursa City Hospital Ethics Committee Approval Date: 15.10.2025 Decision No: 2025-20/9

Thanks

none

References

  1. 1. Feigin VL, Vos T, Nichols E, et al. The global burden of neurological disorders: translating evidence into policy. Lancet Neurol. 2020;19(3):255-265. doi:10.1016/S1474-4422(19)30411-9.
  2. 2. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Espada-Rubio S, Agúndez JA. Oxidative stress and migraine. Mol Neurobiol. 2024;61(10):8344-8360. doi:10.1007/s12035-024-04114-7.
  3. 3. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27(6-7):608-619. doi:10.1080/15257770802138558
  4. 4. Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582(13):1783-1787. doi:10.1016/j.febslet.2008.04.057
  5. 5. Yalcinkaya D, Karacali K, Ilhan BC, Yarlioglues M. Relation between serum uric acid to albumin ratio and severity of chronic coronary artery disease. Angiology. 2024;75(4):386-393. doi:10.1177/00033197231161902
  6. 6. Altunkaynak Y, Keskek A, Donmezler S, et al. A study of the relationship between serum uric acid levels and pain in patients with migraine. Medicine (Baltimore). 2023;102(5):e32810. doi: 10.1097/MD.0000000000032810.
  7. 7. Yazar T, Yazar HO, Aygün A, Karabacak V, Altunkaynak Y, Kirbaş D. Evaluation of serum uric levels in migraine. Neurol Sci. 2021;42(2):705-709. doi:10.1007/s10072-020-04598-w
  8. 8. Yang Z, Xu P, Geng C, Zhang H. Evaluation of simple antioxidant blood parameters in patients with migraine. Front Neurol. 2022;13:939363. doi:10.3389/fneur.2022.939363

Details

Primary Language

English

Subjects

Neurology and Neuromuscular Diseases

Journal Section

Research Article

Publication Date

March 16, 2026

Submission Date

November 6, 2025

Acceptance Date

February 26, 2026

Published in Issue

Year 2026 Volume: 52

APA
Kamacı Şener, D., & Çalışkan Kamışlı, Ö. (2026). Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden. Journal of Uludağ University Medical Faculty, 52, 1813892. https://doi.org/10.32708/uutfd.1813892
AMA
1.Kamacı Şener D, Çalışkan Kamışlı Ö. Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden. Journal of Uludağ University Medical Faculty. 2026;52:1813892. doi:10.32708/uutfd.1813892
Chicago
Kamacı Şener, Deniz, and Özden Çalışkan Kamışlı. 2026. “Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association With Disease Burden”. Journal of Uludağ University Medical Faculty 52 (March): 1813892. https://doi.org/10.32708/uutfd.1813892.
EndNote
Kamacı Şener D, Çalışkan Kamışlı Ö (March 1, 2026) Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden. Journal of Uludağ University Medical Faculty 52 1813892.
IEEE
[1]D. Kamacı Şener and Ö. Çalışkan Kamışlı, “Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden”, Journal of Uludağ University Medical Faculty, vol. 52, p. 1813892, Mar. 2026, doi: 10.32708/uutfd.1813892.
ISNAD
Kamacı Şener, Deniz - Çalışkan Kamışlı, Özden. “Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association With Disease Burden”. Journal of Uludağ University Medical Faculty 52 (March 1, 2026): 1813892. https://doi.org/10.32708/uutfd.1813892.
JAMA
1.Kamacı Şener D, Çalışkan Kamışlı Ö. Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden. Journal of Uludağ University Medical Faculty. 2026;52:1813892.
MLA
Kamacı Şener, Deniz, and Özden Çalışkan Kamışlı. “Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association With Disease Burden”. Journal of Uludağ University Medical Faculty, vol. 52, Mar. 2026, p. 1813892, doi:10.32708/uutfd.1813892.
Vancouver
1.Deniz Kamacı Şener, Özden Çalışkan Kamışlı. Interictal Serum Uric Acid, Albumin, and Uric Acid-to-Albumin Ratio in Episodic Migraine: A Case–Control Study and Association with Disease Burden. Journal of Uludağ University Medical Faculty. 2026 Mar. 1;52:1813892. doi:10.32708/uutfd.1813892

ISSN: 1300-414X, e-ISSN: 2645-9027

Creative Commons License
Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
2023