Research Article

Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry

Volume: 52 June 18, 2026
TR EN

Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry

Abstract

Cavum septum pellucidum (CSP), cavum vergae (CV), cavum veli interpositi (CVI), and interthalamic adhesion (IA) are midline developmental variants and their associations with psychiatric disorders are unclear. Our study aimed to compare the prevalence of these four structures and the dimensional features of CSP in bipolar disorder (BD), major depression (MD), and obsessive-compulsive disorder (OCD) with healthy controls (HC) under a single MRI protocol. A total of 454 adults with 1.5T brain MRI were examined retrospectively. CSP length ≤6 mm was classified as “small,” >6 mm as “large”; the presence of CV, CVI, and IA was evaluated by two blinded radiologists. When all participants (patients and healthy controls) were considered together, CSP prevalence was 61.5%. “Large” CSP was observed only in clinical groups (BD 23.8%; MD 38.1%; OCD 38.1%). CVI was found in 37.4% of OCD and 29.9% of MD patients, showing a significant increase compared to 10.5% in HC (p<0.001). CV prevalence was 16.3% in HC; 35.6% in OCD; 28.8% in MD (p<0.001). Absence of IA was found in 64.6% of patients and 35.4% of HC, revealing an intergroup difference (p<0.05). In BD, MD, and especially OCD, the prevalence of CSP, CV, and CVI, along with IA absence, was significantly increased compared to HC. The findings suggest that these variants are not limited to psychotic disorders and may have neurodevelopmental biomarker potential across a broader mood/anxiety spectrum, emphasizing the need for prospective validation studies.

Keywords

Ethical Statement

Approval was obtained from the Ethics Committee of Bayındır Hospital (BTEDK-06/25). The procedures used in this study adhered to the tenets of the Declaration of 1964 Helsinki.

References

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Details

Primary Language

English

Subjects

Psychiatry, Radiology and Organ Imaging, Anatomy

Journal Section

Research Article

Publication Date

June 18, 2026

Submission Date

February 3, 2026

Acceptance Date

May 5, 2026

Published in Issue

Year 2026 Volume: 52

APA
Altıntaş, H. M., Poyraz, İ., Kamar, Z., Köksal, A., Tuğtağ Demir, B., & Bilecenoğlu, B. (2026). Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry. Journal of Uludağ University Medical Faculty, 52. https://doi.org/10.32708/uutfd.1881027
AMA
1.Altıntaş HM, Poyraz İ, Kamar Z, Köksal A, Tuğtağ Demir B, Bilecenoğlu B. Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1881027
Chicago
Altıntaş, Hilal Melis, İbrahim Poyraz, Zeyad Kamar, Ali Köksal, Berin Tuğtağ Demir, and Burak Bilecenoğlu. 2026. “Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry”. Journal of Uludağ University Medical Faculty 52 (June). https://doi.org/10.32708/uutfd.1881027.
EndNote
Altıntaş HM, Poyraz İ, Kamar Z, Köksal A, Tuğtağ Demir B, Bilecenoğlu B (June 1, 2026) Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry. Journal of Uludağ University Medical Faculty 52
IEEE
[1]H. M. Altıntaş, İ. Poyraz, Z. Kamar, A. Köksal, B. Tuğtağ Demir, and B. Bilecenoğlu, “Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry”, Journal of Uludağ University Medical Faculty, vol. 52, June 2026, doi: 10.32708/uutfd.1881027.
ISNAD
Altıntaş, Hilal Melis - Poyraz, İbrahim - Kamar, Zeyad - Köksal, Ali - Tuğtağ Demir, Berin - Bilecenoğlu, Burak. “Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry”. Journal of Uludağ University Medical Faculty 52 (June 1, 2026). https://doi.org/10.32708/uutfd.1881027.
JAMA
1.Altıntaş HM, Poyraz İ, Kamar Z, Köksal A, Tuğtağ Demir B, Bilecenoğlu B. Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1881027.
MLA
Altıntaş, Hilal Melis, et al. “Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry”. Journal of Uludağ University Medical Faculty, vol. 52, June 2026, doi:10.32708/uutfd.1881027.
Vancouver
1.Hilal Melis Altıntaş, İbrahim Poyraz, Zeyad Kamar, Ali Köksal, Berin Tuğtağ Demir, Burak Bilecenoğlu. Midline Cavum Variants and Adhesio Interthalamica in Psychiatric Disorders: Prevalence and MRI Morphometry. Journal of Uludağ University Medical Faculty. 2026 Jun. 1;52. doi:10.32708/uutfd.1881027

ISSN: 1300-414X, e-ISSN: 2645-9027

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