Research Article

Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study

Volume: 52 October 7, 2026
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Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study

Abstract

The kidneys are frequently affected by anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides, and this renal involvement is a significant determinant of the disease's prognosis. Certain demographic, laboratory, and histopathological findings are effective in predicting kidney and patient survival. The objective of this research was to evaluate both the prognostic utility of the Berden histopathological classification and the determinants of survival among patients with ANCA-associated vasculitis (AAV) and concurrent renal involvement, who were diagnosed at Bursa Uludağ University Hospital. This retrospective analysis comprised 47 cases of AAV identified from a cohort of 1954 patients who underwent renal biopsy at our institution between 1987 and 2017. The demographic, histopathological, and laboratory findings of the patients were examined. Glomerular findings in renal biopsies were evaluated to classify the histopathology and calculate the percentage of normal glomeruli. The prognostic value of these parameters for predicting first-year treatment responses (remission, end-stage renal disease, and death) was evaluated. Histopathological classification, the percentage of normal glomeruli, baseline creatinine, eGFR, proteinuria, and C-reactive protein (CRP) levels were all identified as significant predictors of first-year treatment response (p = 0.046, p = 0.004, p = 0.026, p = 0.021, p = 0.039, and p = 0.016, respectively). While the focal group showed the best prognosis, the sclerotic group had the worst. Factors associated with a poor prognosis included a low normal glomerular percentage in the kidney biopsy, low baseline eGFR, and high levels of baseline serum creatinine, CRP, and proteinuria. Histopathological biopsy findings, histopathological classification model, and certain laboratory markers are effective predictors of treatment response and prognosis in ANCA-associated glomerulonephritis.

Keywords

References

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Details

Primary Language

English

Subjects

​Internal Diseases

Journal Section

Research Article

Publication Date

October 7, 2026

Submission Date

March 24, 2026

Acceptance Date

September 16, 2026

Published in Issue

Year 2026 Volume: 52

APA
Aydın, M. F., Oruç, A., Aytaç Vuruşkan, B., Akgür, S., Ayar, Y., Güllülü, M., Dilek, K., Yavuz, M., Ersoy, A., & Yıldız, A. (2026). Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study. Journal of Uludağ University Medical Faculty, 52. https://doi.org/10.32708/uutfd.1915048
AMA
1.Aydın MF, Oruç A, Aytaç Vuruşkan B, et al. Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1915048
Chicago
Aydın, Mehmet Fethullah, Ayşegül Oruç, Berna Aytaç Vuruşkan, et al. 2026. “Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis With Renal Involvement: A Single-Center Retrospective Cohort Study”. Journal of Uludağ University Medical Faculty 52 (October). https://doi.org/10.32708/uutfd.1915048.
EndNote
Aydın MF, Oruç A, Aytaç Vuruşkan B, Akgür S, Ayar Y, Güllülü M, Dilek K, Yavuz M, Ersoy A, Yıldız A (October 1, 2026) Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study. Journal of Uludağ University Medical Faculty 52
IEEE
[1]M. F. Aydın et al., “Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study”, Journal of Uludağ University Medical Faculty, vol. 52, Oct. 2026, doi: 10.32708/uutfd.1915048.
ISNAD
Aydın, Mehmet Fethullah - Oruç, Ayşegül - Aytaç Vuruşkan, Berna - Akgür, Suat - Ayar, Yavuz - Güllülü, Mustafa - Dilek, Kamil - Yavuz, Mahmut - Ersoy, Alparslan - Yıldız, Abdülmecit. “Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis With Renal Involvement: A Single-Center Retrospective Cohort Study”. Journal of Uludağ University Medical Faculty 52 (October 1, 2026). https://doi.org/10.32708/uutfd.1915048.
JAMA
1.Aydın MF, Oruç A, Aytaç Vuruşkan B, Akgür S, Ayar Y, Güllülü M, Dilek K, Yavuz M, Ersoy A, Yıldız A. Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study. Journal of Uludağ University Medical Faculty. 2026;52. doi:10.32708/uutfd.1915048.
MLA
Aydın, Mehmet Fethullah, et al. “Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis With Renal Involvement: A Single-Center Retrospective Cohort Study”. Journal of Uludağ University Medical Faculty, vol. 52, Oct. 2026, doi:10.32708/uutfd.1915048.
Vancouver
1.Mehmet Fethullah Aydın, Ayşegül Oruç, Berna Aytaç Vuruşkan, Suat Akgür, Yavuz Ayar, Mustafa Güllülü, Kamil Dilek, Mahmut Yavuz, Alparslan Ersoy, Abdülmecit Yıldız. Prognostic Value of Berden Histopathological Classification in Anca-Associated Vasculitis with Renal Involvement: A Single-Center Retrospective Cohort Study. Journal of Uludağ University Medical Faculty. 2026 Oct. 1;52. doi:10.32708/uutfd.1915048

ISSN: 1300-414X, e-ISSN: 2645-9027

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