Research Article

Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever

Volume: 52 October 6, 2026
TR EN

Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever

Abstract

Colchicine is the mainstay of treatment of Familial Mediterranean Fever (FMF). In Türkiye, imported compressed colchicine tablets are commonly used before switching to biological treatments in cases where domestic film or sugar-coated colchicine tablets are ineffective or have adverse effects. We aimed to compare different pharmaceutical preparations of colchicine in terms of treatment efficacy and frequency of adverse effects in Turkish FMF patients. Our study included 75 Turkish adult FMF patients followed at the Bursa Uludağ University Faculty of Medicine rheumatology outpatient clinic serving as a single center between January 2016 and December 2019, who were switched from domestic sugar- or film-coated colchicine preparations to imported compressed colchicine tablets due to resistance or adverse effects. Our study included 75 Turkish adult FMF patients followed up in a single center, who were switched to imported compressed colchicine tablets due to resistance or adverse effects while using a sugar or film-coated domestic colchicine preparation. Patient files were accessed retrospectively from the hospital database. The change in pharmaceutical preparation was due to resistance in 84% of patients, and the post-change resistance rate decreased to 17.3%. After the treatment change, the annual median attack frequency and duration, the median C-reactive protein and erythrocyte sedimentation rate in the attack-free period decreased compared to before, and all changes were statistically significant (p<0.001). The preparation was changed due to adverse effects in 29.3% of patients, and the adverse effect rate decreased by 5.3% after the drug change (p<0.001). FMF patients who are resistant to domestically produced coated colchicine tablets or cannot use them due to adverse effects may benefit from imported compressed colchicine tablets. Therefore, the option of imported compressed colchicine should be kept in mind before switching to biological treatments.

Keywords

References

  1. 1.Ozen S, Batu ED. The myths we believed in familial Mediterranean fever: what have we learned in the past years?. Semin Immunopathol. 2015;37(4):363-369. doi:10.1007/s00281-015-0484-6
  2. 2.Lidar M, Livneh A. Familial Mediterranean fever: clinical, molecular and management advancements. Neth J Med. 2007;65(9):318-324.
  3. 3.Booth DR, Bennetts B, Christodoulou J, Steward G. FMF inAustralia: an under-diagnosed disease. Clin Exp Rheumatol. 2002;20(suppl 26):S-90.
  4. 4.Alkadi H, Khubeiz MJ, Jbeily R. Colchicine: a review onchemical structure and clinical usage. Infect Disord DrugTargets. 2018;18:105-121. doi:10.2174/1871526517666171017114901
  5. 5.Goldfinger SE. Colchicine for familial Mediterranean fever. N Engl J Med. 1972;287:1302.
  6. 6.Ozkan E, Okur O, Ekmekci A, Ozcan R, Tag T. A new approach to the treatment of periodic fever. Med Bull Istanbul. 1972;5:44-49.
  7. 7.Dinarello CA, Wolff SM, Goldfinger SE, Dale DC, Alling DW.Colchicine therapy for familial Mediterranean fever: a double-blind trial. N Engl J Med. 1974;291:934-937.
  8. 8.Zemer D, Pras M, Sohar E, et al. Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med. 1986;314:1001-1005.

Details

Primary Language

English

Subjects

Rheumatology and Arthritis

Journal Section

Research Article

Publication Date

October 6, 2026

Submission Date

April 22, 2026

Acceptance Date

September 7, 2026

Published in Issue

Year 2026 Volume: 52

APA
Yılmaz Bozkurt, Z., Lermi, N., Ocak, T., Yağız, B., Coskun, B. N., Pehlivan, Y., & Dalkılıç, H. E. (2026). Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever. Journal of Uludağ University Medical Faculty, 52. https://doi.org/10.32708/uutfd.1933218
AMA
1.Yılmaz Bozkurt Z, Lermi N, Ocak T, et al. Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever. J Uludag Univ Med Fac. 2026;52. doi:10.32708/uutfd.1933218
Chicago
Yılmaz Bozkurt, Zeynep, Nihal Lermi, Tuğba Ocak, et al. 2026. “Different Pharmaceutical Preparations of Colchicine Can Be an Alternative Treatment Before Switching to Biological Agents in Patients With Familial Mediterranean Fever”. Journal of Uludağ University Medical Faculty 52 (October). https://doi.org/10.32708/uutfd.1933218.
EndNote
Yılmaz Bozkurt Z, Lermi N, Ocak T, Yağız B, Coskun BN, Pehlivan Y, Dalkılıç HE (October 1, 2026) Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever. Journal of Uludağ University Medical Faculty 52
IEEE
[1]Z. Yılmaz Bozkurt et al., “Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever”, J Uludag Univ Med Fac, vol. 52, Oct. 2026, doi: 10.32708/uutfd.1933218.
ISNAD
Yılmaz Bozkurt, Zeynep - Lermi, Nihal - Ocak, Tuğba - Yağız, Burcu - Coskun, Belkis Nihan - Pehlivan, Yavuz - Dalkılıç, Hüseyin Ediz. “Different Pharmaceutical Preparations of Colchicine Can Be an Alternative Treatment Before Switching to Biological Agents in Patients With Familial Mediterranean Fever”. Journal of Uludağ University Medical Faculty 52 (October 1, 2026). https://doi.org/10.32708/uutfd.1933218.
JAMA
1.Yılmaz Bozkurt Z, Lermi N, Ocak T, Yağız B, Coskun BN, Pehlivan Y, Dalkılıç HE. Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever. J Uludag Univ Med Fac. 2026;52. doi:10.32708/uutfd.1933218.
MLA
Yılmaz Bozkurt, Zeynep, et al. “Different Pharmaceutical Preparations of Colchicine Can Be an Alternative Treatment Before Switching to Biological Agents in Patients With Familial Mediterranean Fever”. Journal of Uludağ University Medical Faculty, vol. 52, Oct. 2026, doi:10.32708/uutfd.1933218.
Vancouver
1.Zeynep Yılmaz Bozkurt, Nihal Lermi, Tuğba Ocak, Burcu Yağız, Belkis Nihan Coskun, Yavuz Pehlivan, Hüseyin Ediz Dalkılıç. Different Pharmaceutical Preparations of Colchicine can be an Alternative Treatment Before Switching to Biological Agents in Patients with Familial Mediterranean Fever. J Uludag Univ Med Fac. 2026 Oct. 1;52. doi:10.32708/uutfd.1933218

ISSN: 1300-414X, e-ISSN: 2645-9027

Creative Commons License
Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
2023