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Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats
Abstract
The aim of this study was to investigate the effects of central and peripheral injections of a nitric oxide (NO) precursor, L-Arginine on depression,
using a depression model induced by Forced Swim Test (FST) in rats. For this purpose, on the second day of the swim test, rats
were pretreated either intracerebroventricularly (i.c.v.) with saline (4 µl) or L-Arginine (5, 20, 80 µg/4 µl) ten minutes before the test, and the
other group received either saline (1 ml) or L-Arginine (100, 500, 1000 mg/kg) intraperitoneally (i.p.) thirty minutes before the test. İ.c.v. 20
µg/4 µl L-Arginine significantly increased immobility (p<0.05), while decreasing climbing significantly (p<0.05) with respect to the control
group. İ.p. L-Arginine, at doses of 100 mg/kg and 500 mg/kg, also significantly increased immobility (p<0.001) and decreased climbing
(p<0.001) compared to the control group. Thus, the conclusion was that, NO has both central and peripheral dose-related effects on depression
model induced by FST.
Keywords
Details
Primary Language
English
Subjects
-
Journal Section
-
Publication Date
March 1, 2010
Submission Date
March 1, 2010
Acceptance Date
-
Published in Issue
Year 2010 Volume: 36 Number: 1
APA
Uzunok, B., Kahveci, N., & Güleç, G. (2010). Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats. Journal of Uludağ University Medical Faculty, 36(1), 23-28. https://izlik.org/JA56XH28CZ
AMA
1.Uzunok B, Kahveci N, Güleç G. Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats. Journal of Uludağ University Medical Faculty. 2010;36(1):23-28. https://izlik.org/JA56XH28CZ
Chicago
Uzunok, Barış, Nevzat Kahveci, and Güldal Güleç. 2010. “Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats”. Journal of Uludağ University Medical Faculty 36 (1): 23-28. https://izlik.org/JA56XH28CZ.
EndNote
Uzunok B, Kahveci N, Güleç G (March 1, 2010) Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats. Journal of Uludağ University Medical Faculty 36 1 23–28.
IEEE
[1]B. Uzunok, N. Kahveci, and G. Güleç, “Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats”, Journal of Uludağ University Medical Faculty, vol. 36, no. 1, pp. 23–28, Mar. 2010, [Online]. Available: https://izlik.org/JA56XH28CZ
ISNAD
Uzunok, Barış - Kahveci, Nevzat - Güleç, Güldal. “Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats”. Journal of Uludağ University Medical Faculty 36/1 (March 1, 2010): 23-28. https://izlik.org/JA56XH28CZ.
JAMA
1.Uzunok B, Kahveci N, Güleç G. Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats. Journal of Uludağ University Medical Faculty. 2010;36:23–28.
MLA
Uzunok, Barış, et al. “Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats”. Journal of Uludağ University Medical Faculty, vol. 36, no. 1, Mar. 2010, pp. 23-28, https://izlik.org/JA56XH28CZ.
Vancouver
1.Barış Uzunok, Nevzat Kahveci, Güldal Güleç. Role of Nitric Oxide in The Depression Model Induced By Swim Test in Rats. Journal of Uludağ University Medical Faculty [Internet]. 2010 Mar. 1;36(1):23-8. Available from: https://izlik.org/JA56XH28CZ