Retrospective analysis of 152 patients with pustular psoriasis: smoking habit with clinical, demographic characteristics and treatment response

Year 2018, , 71 - 74, 01.08.2018

Serkan Yazici , Gülistan Maçin Eda Haşal Emel Bülbül Başkan , Kenan Aydoğan , Hayriye Sarıcaoğlu , Şaduman Balaban Adım

https://doi.org/10.32708/uutfd.426012

Abstract

In this study, clinical,
demographic characteristics and treatment response of pustular psoriasis cases
and smoking habit were investigated. Total of 152 patients followed clinically and
histopathologically for generalized pustular psoriasis(GPP) and palmoplantar
pustular psoriasis(PPPP) were evaluated for age, sex, age of onset, duration of
lesion, localization, nail, joint involvement, family history for  psoriasis, presence of plaque psoriasis
before diagnosis, presence of comorbidity, triggering factors (drug, infection,
stress), smoking, treatment response, and recurrence were retrieved from file
records, retrospectively. Of
the 152 cases, 27 were diagnosed with GPP 125 as PPPP.
100 of the cases were female
and 52 were male. The mean age of the cases was 41.64 ± 13.58 and the median
was 42,0 (6-73). No
statistically significant difference was found between the subgroups of
pustular psoriasis and the family history of psoriasis, presence of malignancy,
smoking, detectable triggering factor, nail and joint involvement (P>0,05).
There was statistically
significant difference between treatment response and smoking (P =, 014).
There was a statistically
significant correlation between the presence of any triggering factor and
recurrence (P =
,003). There was a statistically significant correlation between
joint involvement and recurrence (P = ,000). Prevention of smoking and assessment of joint involvement is
important in pustular psoriasis management.

Keywords

joint involvement, pustular psoriasis, recurrence, smoking

Püstüler Psoriasis Tanılı 152 Olgunun Retrospektif Analizi: Klinik, Demografik Özellikler ve Tedavi Yanıtı ile Sigara İlişkisi

Abstract

Bu
çalışmada, püstüler psoriasis olgularının klinik, demografik özellikleri ve
tedavi yanıtı ile sigara ilişkisi araştırılmıştır. Klinik ve histopatolojik
olarak generalize püstüler psoriasis ve palmoplantar püstüler psoriasis
tanısıyla takip edilen 152 olgunun yaş, cinsiyet, hastalığın başlangıç yaşı,
lezyon süresi, lokalizasyonu, tırnak, eklem tutulumu, ailede psoriasis varlığı,
tanı öncesi plak psoriasis varlığı, komorbidite varlığı, tetikleyici faktörler
(ilaç, infeksiyon, stres), sigara kullanımı, tedavi yanıtı ve rekürrens gibi parametreler
dosya kayıtlarından retrospektif elde edildi. 152 olgunun 27’si GPP 125’İ PPPP
tanılıydı. Olguların 100’ü bayan 52’si erkek idi. Tanı anındaki yaşları
ortalama 41.64±13.58, medyan 42,0(6-73) olarak saptandı. Ailede psoriasis
varlığı, malignite varlığı, sigara kullanımı, tesbit edilebilen tetikleyici
faktör varlığı, tırnak tutulumu, eklem tutulum özellikleri ile püstüler
psoriazis alt grupları arasında istatistiksel fark saptanmadı (P>0,05).
Tedavi yanıtı ile sigara kullanımı arası istatistiksel fark saptandı(P=,014).
Saptanabilen tetikleyici faktör varlığı ile rekürrens arası istatistiksel
anlamlı ilişki saptandı (P=,003). Eklem tutulumu ile rekürrens arasında
istatistiksel anlamlı ilişki saptandı(P=,000). Sigara kullanımın önlenmesi ve eklem
tutulumunun değerlendirilmesi püstüler psoriasis yönetiminde önemlidir.

Keywords

eklem tutulumu, püstüler psoriasis, rekürrens, , sigara

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