Retrospective analysis of 152 patients with pustular psoriasis: smoking habit with clinical, demographic characteristics and treatment response

Abstract

In this study, clinical, demographic characteristics and treatment response of pustular psoriasis cases and smoking habit were investigated. Total of 152 patients followed clinically and histopathologically for generalized pustular psoriasis(GPP) and palmoplantar pustular psoriasis(PPPP) were evaluated for age, sex, age of onset, duration of lesion, localization, nail, joint involvement, family history for  psoriasis, presence of plaque psoriasis before diagnosis, presence of comorbidity, triggering factors (drug, infection, stress), smoking, treatment response, and recurrence were retrieved from file records, retrospectively. Of the 152 cases, 27 were diagnosed with GPP 125 as PPPP. 100 of the cases were female and 52 were male. The mean age of the cases was 41.64 ± 13.58 and the median was 42,0 (6-73). No statistically significant difference was found between the subgroups of pustular psoriasis and the family history of psoriasis, presence of malignancy, smoking, detectable triggering factor, nail and joint involvement (P>0,05). There was statistically significant difference between treatment response and smoking (P =, 014). There was a statistically significant correlation between the presence of any triggering factor and recurrence (P = ,003). There was a statistically significant correlation between joint involvement and recurrence (P = ,000). Prevention of smoking and assessment of joint involvement is important in pustular psoriasis management.

Keywords

• joint involvement,pustular psoriasis,recurrence,smoking

Püstüler Psoriasis Tanılı 152 Olgunun Retrospektif Analizi: Klinik, Demografik Özellikler ve Tedavi Yanıtı ile Sigara İlişkisi

Abstract

Bu çalışmada, püstüler psoriasis olgularının klinik, demografik özellikleri ve tedavi yanıtı ile sigara ilişkisi araştırılmıştır. Klinik ve histopatolojik olarak generalize püstüler psoriasis ve palmoplantar püstüler psoriasis tanısıyla takip edilen 152 olgunun yaş, cinsiyet, hastalığın başlangıç yaşı, lezyon süresi, lokalizasyonu, tırnak, eklem tutulumu, ailede psoriasis varlığı, tanı öncesi plak psoriasis varlığı, komorbidite varlığı, tetikleyici faktörler (ilaç, infeksiyon, stres), sigara kullanımı, tedavi yanıtı ve rekürrens gibi parametreler dosya kayıtlarından retrospektif elde edildi. 152 olgunun 27’si GPP 125’İ PPPP tanılıydı. Olguların 100’ü bayan 52’si erkek idi. Tanı anındaki yaşları ortalama 41.64±13.58, medyan 42,0(6-73) olarak saptandı. Ailede psoriasis varlığı, malignite varlığı, sigara kullanımı, tesbit edilebilen tetikleyici faktör varlığı, tırnak tutulumu, eklem tutulum özellikleri ile püstüler psoriazis alt grupları arasında istatistiksel fark saptanmadı (P>0,05). Tedavi yanıtı ile sigara kullanımı arası istatistiksel fark saptandı(P=,014). Saptanabilen tetikleyici faktör varlığı ile rekürrens arası istatistiksel anlamlı ilişki saptandı (P=,003). Eklem tutulumu ile rekürrens arasında istatistiksel anlamlı ilişki saptandı(P=,000). Sigara kullanımın önlenmesi ve eklem tutulumunun değerlendirilmesi püstüler psoriasis yönetiminde önemlidir.

Keywords

• eklem tutulumu,püstüler psoriasis,rekürrens,, sigara

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