A Rare Cause of Pathological Fracture: Amyloidoma

Abstract

Amyloidoma is a tumoral formation in which accumulation of amylodin occurs in various tissues, especially in the extracellular space, resulting in a localized mass. The frequent localization is mediastinum and retroperitoneal region and bone localizationis extremely rare. The diagnosis of amyloidoma is based on histopathological, immunohistochemical and histochemical evaluation. In this report, a 70-year-old man presented with pathological femur fracture and intense amyloid deposition in the bone is presented with literature data.

Keywords

• Amyloid,Amyloidoma,Bone,Pathological fracture

Nadir Bir Patolojik Kırık Nedeni: Amiloidoma

Abstract

Amiloidoma, amilodin değişik dokularda özellikle ekstrasellüler alanda lokalize bir kitle oluşturacak şekilde birikimi ile meydana gelen tümöral bir oluşumdur. En sık lokalizasyon mediasten ve retroperiton olup kemik tutulumu oldukça nadirdir. Amiloidoma tanısı histopatolo-jik, immünohistokimyasal ve histokimyasal değerlendirmeye dayanmaktadır. Olgu sunumumuzda patolojik femur kırığı ile başvuran ve kemikte yoğun amiloid birikimi saptanan 70 yaşındaki erkek hasta literatür bilgisi eşliğinde sunulmuştur.

Keywords

• Amiloid,Amiloidoma,Kemik,Patolojik kırık

References

1. 1. Kumar V, Abbas K, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed Elsevier China; 2005.259-264.
2. 2. Rosai J. Rosai ve Ackerman'ın Cerrahi patolojisi.10.Baskı. İstanbul;2015. 1118-21.
3. 3. Lu W, Wang Y, Zhang M, et al. Primary localized amyloidoma of the renal pelvis: A case report and literature review. On-collLett2016;11:1095-100.
4. 4. Nas K, Arslan A,Ceviz A, et al. Spinal Cord Compression by Primary Amyloidoma of the Spine. YonseiMedJ 2002;43:681-5.
5. 5. Fierens J, Mees U, Vanbockrijck M, Hendrikx M. Amyloidoma of the chest wall: A rare entity. İnteractCardiovascThoracSurg 2008;7:1194-5.
6. 6. Oruçkaptan H, Karlı Oğuz K, Işıkay İ, Ruacan Ş. Amyloidoma of the Temporal Bone and Upper Cervical Spine; Presentation of a Rare Clinical Entity with a Brief Literature Review. Turk-Neurosurg2009;19:159-62.
7. 7. Safi S, Winkel J, Schnabel PA, et al. Extended Resection of a Plasmocytoma of Bone and an Amyloidoma of the Chest Wall. AnnThoracSurg 2013;96:2223-5.
8. 8. Brawanski N, Platz J, Seifert V, Marquardt G, Weise LM. Differentiated plasma cell myeloma presenting as a solitary spinal amyloidoma: A case report, possible pitfall and review to the literature. ClinNeurolNeurosurg 2015;137:1-4.

9. 9. Krishnan J, Chu WS, ElrodJ P, Frizzera G. Tumoral Presenta-tion of Amyloidosis (Amyloidomas) in Soft Tissues: A report of 14 cases. Am J ClinPathol 1993;100:135-44.
10. 10. Goldblum JR, Folpe AL, Weiss SW. Enzinger and Weiss's Soft Tissue Tumors. 6rd edition. Philadelphia;2014. 963-66.
11. 11. Sandal G, Yüksel F. Localized Amyloid Tumor of the Maxil-lary Sinus. Selçuk Tıp Dergisi 2015;31(2):83-4.
12. 12. Verhoeven F, Prati C, Wendling D. Amyloidoma, an Unusual Cause of Fracture. Case reports in Rheumatology 2014; Article ID 424056,3 pages.doi: 10.1155/2014/424056
13. 13. Simoens WA, Hauwe L, Hedent EV, et al.Amyloidoma of the Skull Base. AJNR Am J Neuroradiol 2000;21:1559-62.
14. 14. Kumar S, Kumar S, Ahmad A, Kumar A. Primary Amyloidoma of Chest wall- A rare condition. BMJ Case Reports 2012; doi:10.1136/bcr.01.2012.5552.