Current Approaches in Vitamin D Treatment

Abstract

Vitamin D is a steroid hormone that is very important for bone and mineral metabolism. Nowadays, deficiency or insufficiency of vitamin D is seen in increasing frequency. The fact that vitamin D deficiency may be associated with different acute and chronic diseases other than bone and mineral metabolism increased the interest to vitamin D in recent years. In this review, vitamin D, reasons leading to its deficiency, important factors and current approaches in diagnosis, treatment and follow-up are discussed.

Keywords

• Vitamin D,deficiency,diagnosis,treatment

Vitamin D Tedavisinde Güncel Yaklaşımlar

Abstract

Vitamin D steroid yapıda bir hormon olup kemik ve mineral metabolizması için çok önemlidir. Günümüzde eksikliği ve yetersizliği giderek artan sıklıkta görülmektedir. Vitamin D eksikliğinin kemik ve mineral metabolizması dışında farklı akut ve kronik hastalıklarla ilişkili olabileceğinin gösterilmesi son yıllarda vitamin D’ye olan ilgiyi artırmıştır. Bu derlemede vitamin D, eksikliğine yol açan nedenler, tanı, tedavi ve takipte önemli faktörler ve güncel yaklaşımlar tartışılmıştır. 

Keywords

• Vitamin D,eksiklik,tanı,tedavi

References

1. 1. Pilz S, Zittermann A, Trummer C, Schwetz V, Lerchbaum E, Keppel M, Grübler M, Maerz W, Pandis M. Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect 2019;8(2):R27-R43. doi: 10.1530/EC-18-0432.
2. 2. Türkiye Endokrinoloji ve Metabolizma Derneği, Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu, 2018.
3. 3. Kamboj P, Dwivedi S, Toteja GS. Prevalence of hypovitaminosis D in India & way forward. Indian J Med Res 2018;148(5):548-56. doi: 10.4103/ijmr.IJMR_1807_18
4. 4. Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T, Güçlü F, Ozmen B. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10:782. doi: 10.1186/1471-2458-10-782.
5. 5. Pazirandeh S, Burns DL. Overview of vitamin D. UpToDate Jan 2019. https://www.uptodate.com.
6. 6. Walsh JS, Bowles S, Evans AL. Vitamin D in obesity. Curr Opin Endocrinol Diabetes Obes 2017;24(6):389-94. doi: 10.1097/MED.0000000000000371.
7. 7. Acarkan T. D vitamini. Bilimsel Tamamlayıcı Tıp, Regülasyon ve Nöralterapi Dergisi 2015;9(3):5-8.
8. 8. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-30. doi: 10.1210/jc.2011-0385.

9. 9. American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. J Am Geriatr Soc 2014;62(1):147-52. doi: 10.1111/jgs.12631.
10. 10. Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011;31(1):48-54. doi: 10.1016/j.nutres.2010.12.001.
11. 11. Cigerli O, Parildar H, Unal AD, Tarcin O, Erdal R, Guvener Demirag N. Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public Health Nutr 2013;16(7):1306-13. doi: 10.1017/S1368980012003588.
12. 12. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Arch Gerontol Geriatr 2005;40(1):53-60.13. Durazo-Arvizu RA1, Dawson-Hughes B, Sempos CT, Yetley EA, Looker AC, Cao G, Harris SS, Burt VL, Carriquiry AL, Picciano MF. Three-phase model harmonizes estimates of the maximal suppression of parathyroid hormone by 25-hydroxyvitamin D in persons 65 years of age and older. J Nutr 2010;140(3):595-9. doi: 10.3945/jn.109.116681.
13. 14. Valcour A, Blocki F, Hawkins DM, Rao SD. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels.J Clin Endocrinol Metab 2012;97(11):3989-95. doi: 10.1210/jc.2012-2276.
14. 15. Need AG, O'Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BE. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res 2008;23(11):1859-63. doi: 10.1359/jbmr.080607.
15. 16. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326(7387):469.
16. 17. Dawson-Hughes B. Vitamin D deficiency in adults: Definition, clinical manifestations, and treatment. UpToDate Jan 2019. https://www.uptodate.com.
17. 18. Bouillon R, Carmeliet G. Vitamin D insufficiency: Definition, diagnosis and management. Best Pract Res Clin Endocrinol Metab 2018;32(5):669-684. doi: 10.1016/j.beem.2018.09.014.
18. 19. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011;118(1):197-8. doi: 10.1097/AOG.0b013e318227f06b.
19. 20. Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, Lips P. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab 2013;98(8):E1283-304. doi: 10.1210/jc.2013-1195.
20. 21. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010;152(5):307-14. doi: 10.7326/0003-4819-152-5-201003020-00009. 22. Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, Gerstein HC, Perkins BA, Harris SB, Zinman B, Hanley AJ. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010;33(6):1379-81. doi: 10.2337/dc09-2321.
21. 23. Cheng S, Massaro JM, Fox CS, Larson MG, Keyes MJ, McCabe EL, Robins SJ, O'Donnell CJ, Hoffmann U, Jacques PF, Booth SL, Vasan RS, Wolf M, Wang TJ. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 2010;59(1):242-8. doi: 10.2337/db09-1011.
22. 24. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 2012;33(3):456-92. doi: 10.1210/er.2012-1000.
23. 25. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and extra-skeletal actions of vitamin D: Current evidence and outstanding questions. Endocr Rev 2018 Oct 12. doi: 10.1210/er.2018-00126. [Epub ahead of print]